Nematode-Induced Growth Factors Related to Angiogenesis in Autoimmune Disease Attenuation
Accumulating data suggest an important role of growth factors in autoimmune diseases and parasitic nematode infections. Nematodes are used in clinical studies of autoimmune diseases and parasite-derived molecules are widely studied for their therapeutic potential in various types of disorders. Howev...
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MDPI AG
2023-01-01
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| Series: | Life |
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| author | Marta Maruszewska-Cheruiyot Katarzyna Krawczak-Wójcik Martyna Michniowska Michael James Stear Maja Machcińska Maria Doligalska Katarzyna Donskow-Łysoniewska |
| author_facet | Marta Maruszewska-Cheruiyot Katarzyna Krawczak-Wójcik Martyna Michniowska Michael James Stear Maja Machcińska Maria Doligalska Katarzyna Donskow-Łysoniewska |
| author_sort | Marta Maruszewska-Cheruiyot |
| collection | DOAJ |
| description | Accumulating data suggest an important role of growth factors in autoimmune diseases and parasitic nematode infections. Nematodes are used in clinical studies of autoimmune diseases and parasite-derived molecules are widely studied for their therapeutic potential in various types of disorders. However, the effect of nematode infection on growth factors in autoimmune disorders has not been studied. The objective of this study was to evaluate the influence of infection with the intestinal nematode <i>Heligmosomoides polygyrus</i> in murine autoimmune models on the production of growth factors. Here, the level of a variety of growth factors related mainly to angiogenesis was evaluated by protein array in the intestinal mucosa of C57BL/6 dextran sodium sulfate-induced colitic mice and in cerebral spinal fluid of experimental autoimmune encephalomyelitis (EAE) mice infected with nematodes. In addition, vessel formation was evaluated in the brains of EAE mice infected with <i>H. polygyrus</i>. A significant influence of nematode infection on the level of angiogenic factors was observed. Parasitic infection of colitic mice resulted in upregulation of mucosal AREG, EGF, FGF-2, and IGFBP-3 in the intestine of the host and better adaptation (infectivity). In EAE mice, infection increased the level of FGF-2 and FGF-7 in CSF. In addition, remodeling of brain vessels was observed, with a higher density of long vessels. Nematode-derived factors are promising tools to fight autoimmune diseases and to study angiogenesis. |
| first_indexed | 2024-03-11T08:33:56Z |
| format | Article |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:33:56Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-c05560dd75424103b8fb4257c063b4542023-11-16T21:39:39ZengMDPI AGLife2075-17292023-01-0113232110.3390/life13020321Nematode-Induced Growth Factors Related to Angiogenesis in Autoimmune Disease AttenuationMarta Maruszewska-Cheruiyot0Katarzyna Krawczak-Wójcik1Martyna Michniowska2Michael James Stear3Maja Machcińska4Maria Doligalska5Katarzyna Donskow-Łysoniewska6Laboratory of Parasitology, General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, PolandLaboratory of Parasitology, General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, PolandDepartment of Parasitology, Institute of Functional Biology and Ecology, Faculty of Biology, University of Warsaw, 02-096 Warsaw, PolandDepartment of Animal, Plant and Soil Science, Agribio, La Trobe University, Bundoora 3086, AustraliaDepartment of Experimental Immunotherapy, Faculty of Medicine, Lazarski University, 02-662 Warsaw, PolandDepartment of Parasitology, Institute of Functional Biology and Ecology, Faculty of Biology, University of Warsaw, 02-096 Warsaw, PolandLaboratory of Parasitology, General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, PolandAccumulating data suggest an important role of growth factors in autoimmune diseases and parasitic nematode infections. Nematodes are used in clinical studies of autoimmune diseases and parasite-derived molecules are widely studied for their therapeutic potential in various types of disorders. However, the effect of nematode infection on growth factors in autoimmune disorders has not been studied. The objective of this study was to evaluate the influence of infection with the intestinal nematode <i>Heligmosomoides polygyrus</i> in murine autoimmune models on the production of growth factors. Here, the level of a variety of growth factors related mainly to angiogenesis was evaluated by protein array in the intestinal mucosa of C57BL/6 dextran sodium sulfate-induced colitic mice and in cerebral spinal fluid of experimental autoimmune encephalomyelitis (EAE) mice infected with nematodes. In addition, vessel formation was evaluated in the brains of EAE mice infected with <i>H. polygyrus</i>. A significant influence of nematode infection on the level of angiogenic factors was observed. Parasitic infection of colitic mice resulted in upregulation of mucosal AREG, EGF, FGF-2, and IGFBP-3 in the intestine of the host and better adaptation (infectivity). In EAE mice, infection increased the level of FGF-2 and FGF-7 in CSF. In addition, remodeling of brain vessels was observed, with a higher density of long vessels. Nematode-derived factors are promising tools to fight autoimmune diseases and to study angiogenesis.https://www.mdpi.com/2075-1729/13/2/321experimental autoimmune encephalomyelitiscolitisgrowth factorsnematode adaptationangiogenesis |
| spellingShingle | Marta Maruszewska-Cheruiyot Katarzyna Krawczak-Wójcik Martyna Michniowska Michael James Stear Maja Machcińska Maria Doligalska Katarzyna Donskow-Łysoniewska Nematode-Induced Growth Factors Related to Angiogenesis in Autoimmune Disease Attenuation Life experimental autoimmune encephalomyelitis colitis growth factors nematode adaptation angiogenesis |
| title | Nematode-Induced Growth Factors Related to Angiogenesis in Autoimmune Disease Attenuation |
| title_full | Nematode-Induced Growth Factors Related to Angiogenesis in Autoimmune Disease Attenuation |
| title_fullStr | Nematode-Induced Growth Factors Related to Angiogenesis in Autoimmune Disease Attenuation |
| title_full_unstemmed | Nematode-Induced Growth Factors Related to Angiogenesis in Autoimmune Disease Attenuation |
| title_short | Nematode-Induced Growth Factors Related to Angiogenesis in Autoimmune Disease Attenuation |
| title_sort | nematode induced growth factors related to angiogenesis in autoimmune disease attenuation |
| topic | experimental autoimmune encephalomyelitis colitis growth factors nematode adaptation angiogenesis |
| url | https://www.mdpi.com/2075-1729/13/2/321 |
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