New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver.
Corticosteroid-binding globulin (CBG) is the specific plasma transport glycoprotein for glucocorticoids. Circulating CBG is mainly synthesized in liver but, its synthesis has been located also in other organs as placenta, kidney and adipose tissue with unknown role. Using an experimental model of ac...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4704799?pdf=render |
| _version_ | 1818144951162109952 |
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| author | Jose Gulfo Angelo Ledda Sabrina Gea-Sorlí Laia Bonjoch Daniel Closa Mar Grasa Montserrat Esteve |
| author_facet | Jose Gulfo Angelo Ledda Sabrina Gea-Sorlí Laia Bonjoch Daniel Closa Mar Grasa Montserrat Esteve |
| author_sort | Jose Gulfo |
| collection | DOAJ |
| description | Corticosteroid-binding globulin (CBG) is the specific plasma transport glycoprotein for glucocorticoids. Circulating CBG is mainly synthesized in liver but, its synthesis has been located also in other organs as placenta, kidney and adipose tissue with unknown role. Using an experimental model of acute pancreatitis in cbg-/- mice we investigated whether changes in CBG affect the progression of the disease as well as the metabolism of glucocorticoids in the lung. Lack of CBG does not modify the progression of inflammation associated to pancreatitis but resulted in the loss of gender differences in corticosterone serum levels. In the lung, CBG expression and protein level were detected, and it is noteworthy that these showed a sexual dimorphism opposite to the liver, i.e. with higher levels in males. Reduced expression of 11β-HSD2, the enzyme involved in the deactivation of corticosterone, was also observed. Our results indicate that, in addition to glucocorticoids transporter, CBG is involved in the gender differences observed in corticosteroids circulating levels and plays a role in the local regulation of corticosteroids availability in organs like lung. |
| first_indexed | 2024-12-11T11:55:43Z |
| format | Article |
| id | doaj.art-c058064f5770434cab2b108b8d6b196e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T11:55:43Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c058064f5770434cab2b108b8d6b196e2022-12-22T01:08:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01111e014649710.1371/journal.pone.0146497New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver.Jose GulfoAngelo LeddaSabrina Gea-SorlíLaia BonjochDaniel ClosaMar GrasaMontserrat EsteveCorticosteroid-binding globulin (CBG) is the specific plasma transport glycoprotein for glucocorticoids. Circulating CBG is mainly synthesized in liver but, its synthesis has been located also in other organs as placenta, kidney and adipose tissue with unknown role. Using an experimental model of acute pancreatitis in cbg-/- mice we investigated whether changes in CBG affect the progression of the disease as well as the metabolism of glucocorticoids in the lung. Lack of CBG does not modify the progression of inflammation associated to pancreatitis but resulted in the loss of gender differences in corticosterone serum levels. In the lung, CBG expression and protein level were detected, and it is noteworthy that these showed a sexual dimorphism opposite to the liver, i.e. with higher levels in males. Reduced expression of 11β-HSD2, the enzyme involved in the deactivation of corticosterone, was also observed. Our results indicate that, in addition to glucocorticoids transporter, CBG is involved in the gender differences observed in corticosteroids circulating levels and plays a role in the local regulation of corticosteroids availability in organs like lung.http://europepmc.org/articles/PMC4704799?pdf=render |
| spellingShingle | Jose Gulfo Angelo Ledda Sabrina Gea-Sorlí Laia Bonjoch Daniel Closa Mar Grasa Montserrat Esteve New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver. PLoS ONE |
| title | New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver. |
| title_full | New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver. |
| title_fullStr | New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver. |
| title_full_unstemmed | New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver. |
| title_short | New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver. |
| title_sort | new roles for corticosteroid binding globulin and opposite expression profiles in lung and liver |
| url | http://europepmc.org/articles/PMC4704799?pdf=render |
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