Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation?
Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease’s pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect...
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| Format: | Article |
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MDPI AG
2020-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/3/535 |
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| author | Stéphane Mélik Parsadaniantz Annabelle Réaux-le Goazigo Anaïs Sapienza Christophe Habas Christophe Baudouin |
| author_facet | Stéphane Mélik Parsadaniantz Annabelle Réaux-le Goazigo Anaïs Sapienza Christophe Habas Christophe Baudouin |
| author_sort | Stéphane Mélik Parsadaniantz |
| collection | DOAJ |
| description | Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease’s pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect on disease progression. Recent research suggests that glaucomatous optic neuropathy is a disease that shares common neuroinflammatory mechanisms with “classical” neurodegenerative pathologies. In addition to the death of retinal ganglion cells (RGCs), neuroinflammation appears to be a key element in the progression and spread of this disease. Indeed, early reactivity of glial cells has been observed in the retina, but also in the central visual pathways of glaucoma patients and in preclinical models of ocular hypertension. Moreover, neuronal lesions are not limited to retinal structure, but also occur in central visual pathways. This review summarizes and puts into perspective the experimental and clinical data obtained to date to highlight the need to develop neuroprotective and immunomodulatory therapies to prevent blindness in glaucoma patients. |
| first_indexed | 2024-03-12T05:56:49Z |
| format | Article |
| id | doaj.art-c05854a473464dcc8dcbe1e0c5ef953e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T05:56:49Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c05854a473464dcc8dcbe1e0c5ef953e2023-09-03T04:32:49ZengMDPI AGCells2073-44092020-02-019353510.3390/cells9030535cells9030535Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation?Stéphane Mélik Parsadaniantz0Annabelle Réaux-le Goazigo1Anaïs Sapienza2Christophe Habas3Christophe Baudouin4Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, FranceSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, FranceSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, FranceService de NeuroImagerie, Centre Hospitalier National d’ophtalmologie des Quinze-Vingts, F-75012 Paris, FranceSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, FranceGlaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease’s pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect on disease progression. Recent research suggests that glaucomatous optic neuropathy is a disease that shares common neuroinflammatory mechanisms with “classical” neurodegenerative pathologies. In addition to the death of retinal ganglion cells (RGCs), neuroinflammation appears to be a key element in the progression and spread of this disease. Indeed, early reactivity of glial cells has been observed in the retina, but also in the central visual pathways of glaucoma patients and in preclinical models of ocular hypertension. Moreover, neuronal lesions are not limited to retinal structure, but also occur in central visual pathways. This review summarizes and puts into perspective the experimental and clinical data obtained to date to highlight the need to develop neuroprotective and immunomodulatory therapies to prevent blindness in glaucoma patients.https://www.mdpi.com/2073-4409/9/3/535ocular hypertensionneuronal degenerationneuroinflammationcentral visual pathway |
| spellingShingle | Stéphane Mélik Parsadaniantz Annabelle Réaux-le Goazigo Anaïs Sapienza Christophe Habas Christophe Baudouin Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation? Cells ocular hypertension neuronal degeneration neuroinflammation central visual pathway |
| title | Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation? |
| title_full | Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation? |
| title_fullStr | Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation? |
| title_full_unstemmed | Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation? |
| title_short | Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation? |
| title_sort | glaucoma a degenerative optic neuropathy related to neuroinflammation |
| topic | ocular hypertension neuronal degeneration neuroinflammation central visual pathway |
| url | https://www.mdpi.com/2073-4409/9/3/535 |
| work_keys_str_mv | AT stephanemelikparsadaniantz glaucomaadegenerativeopticneuropathyrelatedtoneuroinflammation AT annabellereauxlegoazigo glaucomaadegenerativeopticneuropathyrelatedtoneuroinflammation AT anaissapienza glaucomaadegenerativeopticneuropathyrelatedtoneuroinflammation AT christophehabas glaucomaadegenerativeopticneuropathyrelatedtoneuroinflammation AT christophebaudouin glaucomaadegenerativeopticneuropathyrelatedtoneuroinflammation |