Additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse
Abstract Objectives The identification of patients with mitral valve prolapse (MVP) presenting high arrhythmic risk remains challenging. Cardiovascular Magnetic Resonance (CMR) feature tracking (FT) may improve risk stratification. We analyzed the role of CMR-FT parameters in relation to the inciden...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12968-023-00944-x |
| _version_ | 1827280131429761024 |
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| author | Marco Guglielmo Dimitri Arangalage Marco Augusto Bonino Gianmarco Angelini Michela Bonanni Gianluca Pontone Patrizio Pascale Laura Anna Leo Francesco Faletra Jurg Schwitter Giovanni Pedrazzini Pierre Monney Anna Giulia Pavon |
| author_facet | Marco Guglielmo Dimitri Arangalage Marco Augusto Bonino Gianmarco Angelini Michela Bonanni Gianluca Pontone Patrizio Pascale Laura Anna Leo Francesco Faletra Jurg Schwitter Giovanni Pedrazzini Pierre Monney Anna Giulia Pavon |
| author_sort | Marco Guglielmo |
| collection | DOAJ |
| description | Abstract Objectives The identification of patients with mitral valve prolapse (MVP) presenting high arrhythmic risk remains challenging. Cardiovascular Magnetic Resonance (CMR) feature tracking (FT) may improve risk stratification. We analyzed the role of CMR-FT parameters in relation to the incidence of complex ventricular arrhythmias (cVA) in patients with MVP and mitral annular disjunction (MAD). Methods 42 patients with MVP and MAD who underwent 1.5 T CMR were classified as MAD-cVA (n = 23, 55%) in case of cVA diagnosed on a 24-h Holter monitoring and as MAD-noVA in the absence of cVA (n = 19, 45%). MAD length, late gadolinium enhancement (LGE), basal segments myocardial extracellular volume (ECV) and CMR-FT were assessed. Results LGE was more frequent in the MAD-cVA group in comparison with the MAD-noVA group (78% vs 42%, p = 0.002) while no difference was observed in terms of basal ECV. Global longitudinal strain (GLS) was reduced in MAD-cVA compared to MAD-noVA (− 18.2% ± 4.6% vs − 25.1% ± 3.1%, p = 0.004) as well as global circumferential strain (GCS) at the mid-ventricular level (− 17.5% ± 4.7% vs − 21.6% ± 3.1%, p = 0.041). Univariate analysis identified as predictors of the incidence of cVA: GCS, circumferential strain (CS) in the basal and mid infero-lateral wall, GLS, regional longitudinal strain (LS) in the basal and mid-ventricular inferolateral wall. Reduced GLS [Odd ratio (OR):1.56 (confidence interval (CI) 95%: 1.45–2.47; p < 0.001)] and regional LS in the basal inferolateral wall [OR: 1.62 (CI 95%: 1.22–2.13; p < 0.001)] remained independent prognostic factors in multivariate analysis. Conclusion In patients with MVP and MAD, CMR-FT parameters are correlated with the incidence of cVA and may be of interest in arrhythmic risk stratification. |
| first_indexed | 2024-03-13T04:49:49Z |
| format | Article |
| id | doaj.art-c05bc8a828514778a08b3494fd1fac09 |
| institution | Directory Open Access Journal |
| issn | 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:30:29Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-c05bc8a828514778a08b3494fd1fac092024-04-16T19:51:50ZengElsevierJournal of Cardiovascular Magnetic Resonance1532-429X2023-06-0125111310.1186/s12968-023-00944-xAdditional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapseMarco Guglielmo0Dimitri Arangalage1Marco Augusto Bonino2Gianmarco Angelini3Michela Bonanni4Gianluca Pontone5Patrizio Pascale6Laura Anna Leo7Francesco Faletra8Jurg Schwitter9Giovanni Pedrazzini10Pierre Monney11Anna Giulia Pavon12Division of Heart and Lungs, Department of Cardiology, Utrecht University, Utrecht University Medical CenterCardiology Department, AP-HP, Bichat Hospital and Université de ParisDepartment of Surgery, Hopital Universitaire GenèveCardiology Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Policlinico of Bari, University HospitalDepartment of Experimental Medicine, University of Rome “Tor Vergata”Centro Cardiologico Monzino IRCCSDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero CantonaleDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero CantonaleDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero CantonaleDepartment of Cardiology, Lausanne University Hospital (CHUV)Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero CantonaleDepartment of Cardiology, Lausanne University Hospital (CHUV)Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero CantonaleAbstract Objectives The identification of patients with mitral valve prolapse (MVP) presenting high arrhythmic risk remains challenging. Cardiovascular Magnetic Resonance (CMR) feature tracking (FT) may improve risk stratification. We analyzed the role of CMR-FT parameters in relation to the incidence of complex ventricular arrhythmias (cVA) in patients with MVP and mitral annular disjunction (MAD). Methods 42 patients with MVP and MAD who underwent 1.5 T CMR were classified as MAD-cVA (n = 23, 55%) in case of cVA diagnosed on a 24-h Holter monitoring and as MAD-noVA in the absence of cVA (n = 19, 45%). MAD length, late gadolinium enhancement (LGE), basal segments myocardial extracellular volume (ECV) and CMR-FT were assessed. Results LGE was more frequent in the MAD-cVA group in comparison with the MAD-noVA group (78% vs 42%, p = 0.002) while no difference was observed in terms of basal ECV. Global longitudinal strain (GLS) was reduced in MAD-cVA compared to MAD-noVA (− 18.2% ± 4.6% vs − 25.1% ± 3.1%, p = 0.004) as well as global circumferential strain (GCS) at the mid-ventricular level (− 17.5% ± 4.7% vs − 21.6% ± 3.1%, p = 0.041). Univariate analysis identified as predictors of the incidence of cVA: GCS, circumferential strain (CS) in the basal and mid infero-lateral wall, GLS, regional longitudinal strain (LS) in the basal and mid-ventricular inferolateral wall. Reduced GLS [Odd ratio (OR):1.56 (confidence interval (CI) 95%: 1.45–2.47; p < 0.001)] and regional LS in the basal inferolateral wall [OR: 1.62 (CI 95%: 1.22–2.13; p < 0.001)] remained independent prognostic factors in multivariate analysis. Conclusion In patients with MVP and MAD, CMR-FT parameters are correlated with the incidence of cVA and may be of interest in arrhythmic risk stratification.https://doi.org/10.1186/s12968-023-00944-xMitral valve prolapseCardiovascular magnetic resonanceMitral annular disjunctionInterstitial fibrosisStrain |
| spellingShingle | Marco Guglielmo Dimitri Arangalage Marco Augusto Bonino Gianmarco Angelini Michela Bonanni Gianluca Pontone Patrizio Pascale Laura Anna Leo Francesco Faletra Jurg Schwitter Giovanni Pedrazzini Pierre Monney Anna Giulia Pavon Additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse Journal of Cardiovascular Magnetic Resonance Mitral valve prolapse Cardiovascular magnetic resonance Mitral annular disjunction Interstitial fibrosis Strain |
| title | Additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse |
| title_full | Additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse |
| title_fullStr | Additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse |
| title_full_unstemmed | Additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse |
| title_short | Additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse |
| title_sort | additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse |
| topic | Mitral valve prolapse Cardiovascular magnetic resonance Mitral annular disjunction Interstitial fibrosis Strain |
| url | https://doi.org/10.1186/s12968-023-00944-x |
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