Transcriptional Regulation of Liver-Type OATP1B3 (Lt-OATP1B3) and Cancer-Type OATP1B3 (Ct-OATP1B3) Studied in Hepatocyte-Derived and Colon Cancer-Derived Cell Lines

Transcriptional Regulation of Liver-Type OATP1B3 (Lt-OATP1B3) and Cancer-Type OATP1B3 (Ct-OATP1B3) Studied in Hepatocyte-Derived and Colon Cancer-Derived Cell Lines

Due to alternative splicing, the <i>SLCO1B3</i> gene encodes two protein variants; the hepatic uptake transporter liver-type OATP1B3 (Lt-OATP1B3) and the cancer-type OATP1B3 (Ct-OATP1B3) expressed in several cancerous tissues. There is limited information about the cell type-specific tra...

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Bibliographic Details
Main Authors: Bastian Haberkorn, Dennis Löwen, Lukas Meier, Martin F. Fromm, Jörg König
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
Lt-OATP1B3
Ct-OATP1B3
<i>Lt-SLCO1B3</i>
<i>Ct-SLCO1B3</i>
colorectal carcinoma
ZKSCAN3
Online Access:https://www.mdpi.com/1999-4923/15/3/738

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