Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study
Abstract Gene function can be described using various measures. We integrated association studies of three types of omics data to provide insights into the pathophysiology of subclinical coronary disease and myocardial infarction (MI). Using multivariable regression models, we associated: (1) single...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48848-1 |
| _version_ | 1797398035719782400 |
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| author | Amalie Lykkemark Møller Ramachandran S. Vasan Daniel Levy Charlotte Andersson Honghuang Lin |
| author_facet | Amalie Lykkemark Møller Ramachandran S. Vasan Daniel Levy Charlotte Andersson Honghuang Lin |
| author_sort | Amalie Lykkemark Møller |
| collection | DOAJ |
| description | Abstract Gene function can be described using various measures. We integrated association studies of three types of omics data to provide insights into the pathophysiology of subclinical coronary disease and myocardial infarction (MI). Using multivariable regression models, we associated: (1) single nucleotide polymorphism, (2) DNA methylation, and (3) gene expression with coronary artery calcification (CAC) scores and MI. Among 3106 participants of the Framingham Heart Study, 65 (2.1%) had prevalent MI and 60 (1.9%) had incident MI, median CAC value was 67.8 [IQR 10.8, 274.9], and 1403 (45.2%) had CAC scores > 0 (prevalent CAC). Prevalent CAC was associated with AHRR (linked to smoking) and EXOC3 (affecting platelet function and promoting hemostasis). CAC score was associated with VWA1 (extracellular matrix protein associated with cartilage structure in endomysium). For prevalent MI we identified FYTTD1 (down-regulated in familial hypercholesterolemia) and PINK1 (linked to cardiac tissue homeostasis and ischemia–reperfusion injury). Incident MI was associated with IRX3 (enhancing browning of white adipose tissue) and STXBP3 (controlling trafficking of glucose transporter type 4 to plasma). Using an integrative trans-omics approach, we identified both putatively novel and known candidate genes associated with CAC and MI. Replication of findings is warranted. |
| first_indexed | 2024-03-09T01:18:54Z |
| format | Article |
| id | doaj.art-c05cd67a155c4e31975f59346a1ecc65 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T01:18:54Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c05cd67a155c4e31975f59346a1ecc652023-12-10T12:16:51ZengNature PortfolioScientific Reports2045-23222023-12-0113111010.1038/s41598-023-48848-1Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart StudyAmalie Lykkemark Møller0Ramachandran S. Vasan1Daniel Levy2Charlotte Andersson3Honghuang Lin4Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of MedicineSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of MedicineBoston University’s and National Heart, Lung, and Blood Institute’s Framingham Heart StudySection of Cardiovascular Medicine, Department of Medicine, Boston Medical Center, Boston University School of MedicineDepartment of Medicine, University of Massachusetts Chan Medical SchoolAbstract Gene function can be described using various measures. We integrated association studies of three types of omics data to provide insights into the pathophysiology of subclinical coronary disease and myocardial infarction (MI). Using multivariable regression models, we associated: (1) single nucleotide polymorphism, (2) DNA methylation, and (3) gene expression with coronary artery calcification (CAC) scores and MI. Among 3106 participants of the Framingham Heart Study, 65 (2.1%) had prevalent MI and 60 (1.9%) had incident MI, median CAC value was 67.8 [IQR 10.8, 274.9], and 1403 (45.2%) had CAC scores > 0 (prevalent CAC). Prevalent CAC was associated with AHRR (linked to smoking) and EXOC3 (affecting platelet function and promoting hemostasis). CAC score was associated with VWA1 (extracellular matrix protein associated with cartilage structure in endomysium). For prevalent MI we identified FYTTD1 (down-regulated in familial hypercholesterolemia) and PINK1 (linked to cardiac tissue homeostasis and ischemia–reperfusion injury). Incident MI was associated with IRX3 (enhancing browning of white adipose tissue) and STXBP3 (controlling trafficking of glucose transporter type 4 to plasma). Using an integrative trans-omics approach, we identified both putatively novel and known candidate genes associated with CAC and MI. Replication of findings is warranted.https://doi.org/10.1038/s41598-023-48848-1 |
| spellingShingle | Amalie Lykkemark Møller Ramachandran S. Vasan Daniel Levy Charlotte Andersson Honghuang Lin Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study Scientific Reports |
| title | Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study |
| title_full | Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study |
| title_fullStr | Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study |
| title_full_unstemmed | Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study |
| title_short | Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study |
| title_sort | integrated omics analysis of coronary artery calcifications and myocardial infarction the framingham heart study |
| url | https://doi.org/10.1038/s41598-023-48848-1 |
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