HIV, appendectomy and postoperative complications at a reference hospital in Northwest Tanzania: cross-sectional study
<p>Abstract</p> <p>Background</p> <p>Appendicitis is a frequent surgical emergency worldwide. The present study was conducted to determine the prevalence of HIV, and the association of infection with clinical, intraoperative and histological findings and outcome, among...
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| Format: | Article |
| Language: | English |
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BMC
2010-12-01
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| Series: | AIDS Research and Therapy |
| Online Access: | http://www.aidsrestherapy.com/content/7/1/47 |
| _version_ | 1818029010431508480 |
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| author | Heukelbach Jorg Mazigo Humphrey D Giiti Geofrey C Mahalu William |
| author_facet | Heukelbach Jorg Mazigo Humphrey D Giiti Geofrey C Mahalu William |
| author_sort | Heukelbach Jorg |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Appendicitis is a frequent surgical emergency worldwide. The present study was conducted to determine the prevalence of HIV, and the association of infection with clinical, intraoperative and histological findings and outcome, among patients with appendicitis.</p> <p>Methods</p> <p>We performed a cross sectional study at Weill-Bugando Medical Centre in northwest Tanzania. In total, 199 patients undergoing appendectomy were included. Demographic characteristics of patients, clinical features, laboratory, intraoperative and histopathological findings, and HIV serostatus were recorded.</p> <p>Results</p> <p>In total, 26/199 (13.1%) were HIV-seropositive. The HIV-positive population was significantly older (mean age: 38.4 years) than the HIV-negative population (25.3 years; p < 0.001). Leukocytosis was present in 87% of seronegative patients, as compared to 34% in seropositive patients (p = 0.0001), and peritonitis was significantly more frequent among HIV-positives (31% vs. 2%; p < 0.001). The mean (SD) length of hospital stay was significantly longer in HIV-positives (7.12 ± 2.94 days vs. 4.02 ± 1.14 days; p < 0.001); 11.5% of HIV patients developed surgical site infections, as compared to 0.6% in the HIV-negative group (p = 0.004).</p> <p>Conclusion</p> <p>HIV infections are common among patients with appendicitis in Tanzania, and are associated with severe morbidity, postoperative complications and longer hospital stays. Early diagnosis of appendicitis and prompt appendectomy are crucial in areas with high prevalence of HIV infection. Routine pre-test counseling and HIV screening for appendicitis patients is recommended to detect early cases who may benefit from HAART.</p> |
| first_indexed | 2024-12-10T05:12:53Z |
| format | Article |
| id | doaj.art-c06130b412274a99a8b73f8fefadd090 |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-12-10T05:12:53Z |
| publishDate | 2010-12-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-c06130b412274a99a8b73f8fefadd0902022-12-22T02:01:03ZengBMCAIDS Research and Therapy1742-64052010-12-01714710.1186/1742-6405-7-47HIV, appendectomy and postoperative complications at a reference hospital in Northwest Tanzania: cross-sectional studyHeukelbach JorgMazigo Humphrey DGiiti Geofrey CMahalu William<p>Abstract</p> <p>Background</p> <p>Appendicitis is a frequent surgical emergency worldwide. The present study was conducted to determine the prevalence of HIV, and the association of infection with clinical, intraoperative and histological findings and outcome, among patients with appendicitis.</p> <p>Methods</p> <p>We performed a cross sectional study at Weill-Bugando Medical Centre in northwest Tanzania. In total, 199 patients undergoing appendectomy were included. Demographic characteristics of patients, clinical features, laboratory, intraoperative and histopathological findings, and HIV serostatus were recorded.</p> <p>Results</p> <p>In total, 26/199 (13.1%) were HIV-seropositive. The HIV-positive population was significantly older (mean age: 38.4 years) than the HIV-negative population (25.3 years; p < 0.001). Leukocytosis was present in 87% of seronegative patients, as compared to 34% in seropositive patients (p = 0.0001), and peritonitis was significantly more frequent among HIV-positives (31% vs. 2%; p < 0.001). The mean (SD) length of hospital stay was significantly longer in HIV-positives (7.12 ± 2.94 days vs. 4.02 ± 1.14 days; p < 0.001); 11.5% of HIV patients developed surgical site infections, as compared to 0.6% in the HIV-negative group (p = 0.004).</p> <p>Conclusion</p> <p>HIV infections are common among patients with appendicitis in Tanzania, and are associated with severe morbidity, postoperative complications and longer hospital stays. Early diagnosis of appendicitis and prompt appendectomy are crucial in areas with high prevalence of HIV infection. Routine pre-test counseling and HIV screening for appendicitis patients is recommended to detect early cases who may benefit from HAART.</p>http://www.aidsrestherapy.com/content/7/1/47 |
| spellingShingle | Heukelbach Jorg Mazigo Humphrey D Giiti Geofrey C Mahalu William HIV, appendectomy and postoperative complications at a reference hospital in Northwest Tanzania: cross-sectional study AIDS Research and Therapy |
| title | HIV, appendectomy and postoperative complications at a reference hospital in Northwest Tanzania: cross-sectional study |
| title_full | HIV, appendectomy and postoperative complications at a reference hospital in Northwest Tanzania: cross-sectional study |
| title_fullStr | HIV, appendectomy and postoperative complications at a reference hospital in Northwest Tanzania: cross-sectional study |
| title_full_unstemmed | HIV, appendectomy and postoperative complications at a reference hospital in Northwest Tanzania: cross-sectional study |
| title_short | HIV, appendectomy and postoperative complications at a reference hospital in Northwest Tanzania: cross-sectional study |
| title_sort | hiv appendectomy and postoperative complications at a reference hospital in northwest tanzania cross sectional study |
| url | http://www.aidsrestherapy.com/content/7/1/47 |
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