Connectome-wide investigation of altered resting-state functional connectivity in war veterans with and without posttraumatic stress disorder
Altered resting-state functional connectivity in posttraumatic stress disorder (PTSD) suggests neuropathology of the disorder. While seed-based fMRI connectivity analysis is often used for the studies, such analysis requires defining a seed location a priori, which restricts search scope and could b...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158217302735 |
| _version_ | 1819088207036284928 |
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| author | Masaya Misaki Raquel Phillips Vadim Zotev Chung-Ki Wong Brent E. Wurfel Frank Krueger Matthew Feldner Jerzy Bodurka |
| author_facet | Masaya Misaki Raquel Phillips Vadim Zotev Chung-Ki Wong Brent E. Wurfel Frank Krueger Matthew Feldner Jerzy Bodurka |
| author_sort | Masaya Misaki |
| collection | DOAJ |
| description | Altered resting-state functional connectivity in posttraumatic stress disorder (PTSD) suggests neuropathology of the disorder. While seed-based fMRI connectivity analysis is often used for the studies, such analysis requires defining a seed location a priori, which restricts search scope and could bias findings toward presupposed areas. Recently, a comprehensive exploratory voxel-wise connectivity analysis, the connectome-wide association approach, has been introduced using multivariate distance matrix regression (MDMR) for resting-state functional connectivity analysis. The current study performed a connectome-wide investigation of resting-state functional connectivity for war veterans with and without PTSD compared to non-trauma-exposed healthy controls using MDMR.Thirty-five male combat veterans with PTSD (unmedicated), 18 male combat veterans without PTSD (veterans control, VC), and 28 age-matched non-trauma-exposed healthy males (NC) participated in a resting-state fMRI scan. MDMR analysis was used to identify between-groups differences in regions with altered connectivity. The identified regions were used as a seed for post-hoc functional connectivity analysis.The analysis revealed that PTSD patients had hypoconnectivity between the left lateral prefrontal regions and the salience network regions as well as hypoconnectivity between the parahippocampal gyrus and the visual cortex areas. Connectivity between the ventromedial prefrontal cortex and the middle frontal gyrus and between the parahippocampal gyrus and the anterior insula were negatively correlated with PTSD symptom severity. VC subjects also had altered functional connectivity compared to NC, including increased connectivity between the posterior insula and several brain regions and decreased connectivity between the precuneus region and several other brain areas.The decreased connectivity between the lateral prefrontal regions and the salience network regions in PTSD was consistent with previous reports that indicated lowered emotion-regulation function in these regions. The decreased connectivity between the parahippocampal gyrus and visual cortex supported the dual representation theory of PTSD, which suggests dissociation between sensory and contextual memory representations in PTSD. The theory also supposes that the precuneus is a region that triggers retrieval of sensory memory of traumatic events. The decreased connectivity at the precuneus for VC might be associated with suppressing such a process. Keywords: Posttraumatic stress disorder, Resting-state functional connectivity, Multivariate distance-based matrix regression, Connectome-wide association study, fMRI |
| first_indexed | 2024-12-21T21:48:22Z |
| format | Article |
| id | doaj.art-c061b90aba724c499152bc19fe683ba4 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-21T21:48:22Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-c061b90aba724c499152bc19fe683ba42022-12-21T18:49:09ZengElsevierNeuroImage: Clinical2213-15822018-01-0117285296Connectome-wide investigation of altered resting-state functional connectivity in war veterans with and without posttraumatic stress disorderMasaya Misaki0Raquel Phillips1Vadim Zotev2Chung-Ki Wong3Brent E. Wurfel4Frank Krueger5Matthew Feldner6Jerzy Bodurka7Laureate Institute for Brain Research, Tulsa, OK, United StatesLaureate Institute for Brain Research, Tulsa, OK, United StatesLaureate Institute for Brain Research, Tulsa, OK, United StatesLaureate Institute for Brain Research, Tulsa, OK, United StatesLaureate Institute for Brain Research, Tulsa, OK, United States; Laureate Psychiatric Clinic and Hospital, Tulsa, OK, United StatesSchool of Systems Biology, George Mason University, Fairfax, VA, United StatesDept. of Psychological Science, University of Arkansas, Fayetteville, AR, United StatesLaureate Institute for Brain Research, Tulsa, OK, United States; Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States; Corresponding author at: Laureate Institute for Brain Research, Tulsa, OK, United States.Altered resting-state functional connectivity in posttraumatic stress disorder (PTSD) suggests neuropathology of the disorder. While seed-based fMRI connectivity analysis is often used for the studies, such analysis requires defining a seed location a priori, which restricts search scope and could bias findings toward presupposed areas. Recently, a comprehensive exploratory voxel-wise connectivity analysis, the connectome-wide association approach, has been introduced using multivariate distance matrix regression (MDMR) for resting-state functional connectivity analysis. The current study performed a connectome-wide investigation of resting-state functional connectivity for war veterans with and without PTSD compared to non-trauma-exposed healthy controls using MDMR.Thirty-five male combat veterans with PTSD (unmedicated), 18 male combat veterans without PTSD (veterans control, VC), and 28 age-matched non-trauma-exposed healthy males (NC) participated in a resting-state fMRI scan. MDMR analysis was used to identify between-groups differences in regions with altered connectivity. The identified regions were used as a seed for post-hoc functional connectivity analysis.The analysis revealed that PTSD patients had hypoconnectivity between the left lateral prefrontal regions and the salience network regions as well as hypoconnectivity between the parahippocampal gyrus and the visual cortex areas. Connectivity between the ventromedial prefrontal cortex and the middle frontal gyrus and between the parahippocampal gyrus and the anterior insula were negatively correlated with PTSD symptom severity. VC subjects also had altered functional connectivity compared to NC, including increased connectivity between the posterior insula and several brain regions and decreased connectivity between the precuneus region and several other brain areas.The decreased connectivity between the lateral prefrontal regions and the salience network regions in PTSD was consistent with previous reports that indicated lowered emotion-regulation function in these regions. The decreased connectivity between the parahippocampal gyrus and visual cortex supported the dual representation theory of PTSD, which suggests dissociation between sensory and contextual memory representations in PTSD. The theory also supposes that the precuneus is a region that triggers retrieval of sensory memory of traumatic events. The decreased connectivity at the precuneus for VC might be associated with suppressing such a process. Keywords: Posttraumatic stress disorder, Resting-state functional connectivity, Multivariate distance-based matrix regression, Connectome-wide association study, fMRIhttp://www.sciencedirect.com/science/article/pii/S2213158217302735 |
| spellingShingle | Masaya Misaki Raquel Phillips Vadim Zotev Chung-Ki Wong Brent E. Wurfel Frank Krueger Matthew Feldner Jerzy Bodurka Connectome-wide investigation of altered resting-state functional connectivity in war veterans with and without posttraumatic stress disorder NeuroImage: Clinical |
| title | Connectome-wide investigation of altered resting-state functional connectivity in war veterans with and without posttraumatic stress disorder |
| title_full | Connectome-wide investigation of altered resting-state functional connectivity in war veterans with and without posttraumatic stress disorder |
| title_fullStr | Connectome-wide investigation of altered resting-state functional connectivity in war veterans with and without posttraumatic stress disorder |
| title_full_unstemmed | Connectome-wide investigation of altered resting-state functional connectivity in war veterans with and without posttraumatic stress disorder |
| title_short | Connectome-wide investigation of altered resting-state functional connectivity in war veterans with and without posttraumatic stress disorder |
| title_sort | connectome wide investigation of altered resting state functional connectivity in war veterans with and without posttraumatic stress disorder |
| url | http://www.sciencedirect.com/science/article/pii/S2213158217302735 |
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