Causal Association Between Heart Failure and Alzheimer’s Disease: A Two-Sample Bidirectional Mendelian Randomization Study

Causal Association Between Heart Failure and Alzheimer’s Disease: A Two-Sample Bidirectional Mendelian Randomization Study

Background: Traditional observational studies have demonstrated an association between heart failure and Alzheimer’s disease. The strengths of observational studies lie in their speed of implementation, cost, and applicability to rare diseases. However, observational studies have several limitations...

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Bibliographic Details
Main Authors: Chenglin Duan, Jingjing Shi, Guozhen Yuan, Xintian Shou, Ting Chen, Xueping Zhu, Yihan Yang, Yuanhui Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Genetics
Subjects:
Mendelian randomization
heart failure
Alzheimer’s disease
genome-wide association study
single-nucleotide polymorphisms
causal effects
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.772343/full

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