Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients

Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients

Abstract Background Dectin-2, which is a C-type lectin, interacts with the house dust mite (HDM) Dermatophagoides pteronyssinus allergen. This study aimed to investigate whether Dectin-2 blockade by antagonistic monoclonal antibodies (MoAbs) attenuates HDM-induced allergic responses. Methods Two ant...

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Bibliographic Details
Main Authors: Ming-Han Chen, Ming-Ting Huang, Wen-Kuang Yu, Shinn-Shing Lee, Jia-Horng Wang, Ting-Jen R. Cheng, Michael R. Bowman, Shie-Liang Hsieh
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Biomedical Science
Subjects:
House dust mite
Dermatophagoides pteronyssinus
Dectin-2
Asthma
Online Access:https://doi.org/10.1186/s12929-019-0598-6

Internet

https://doi.org/10.1186/s12929-019-0598-6

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