Prognostic potential of preoperative circulating tumor cells to predict the early progression recurrence in hepatocellular carcinoma patients after hepatectomy
Abstract Background The role of circulating tumor cells (CTCs) in prognosis prediction has been actively studied in hepatocellular carcinoma (HCC) patients. However, their efficiency in accurately predicting early progression recurrence (EPR) is unclear. This study aimed to investigate the clinical...
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| Format: | Article |
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BMC
2023-11-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-11629-0 |
| _version_ | 1797414820172005376 |
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| author | Zhan Lu Hanghang Ni Xihua Yang Lihao Tan Haixiao Zhuang Yunning Mo Xingyu Wei Lunan Qi Bangde Xiang |
| author_facet | Zhan Lu Hanghang Ni Xihua Yang Lihao Tan Haixiao Zhuang Yunning Mo Xingyu Wei Lunan Qi Bangde Xiang |
| author_sort | Zhan Lu |
| collection | DOAJ |
| description | Abstract Background The role of circulating tumor cells (CTCs) in prognosis prediction has been actively studied in hepatocellular carcinoma (HCC) patients. However, their efficiency in accurately predicting early progression recurrence (EPR) is unclear. This study aimed to investigate the clinical potential of preoperative CTCs to predict EPR in HCC patients after hepatectomy. Methods One hundred forty-five HCC patients, whose preoperative CTCs were detected, were enrolled. Based on the recurrence times and types, the patients were divided into four groups, including early oligo-recurrence (EOR), EPR, late oligo-recurrence (LOR), and late progression recurrence (LPR). Results Among the 145 patients, 133 (91.7%) patients had a postoperative recurrence, including 51 EOR, 42 EPR, 39 LOR, and 1 LPR patient. Kaplan–Meier survival curve analysis indicated that the HCC patients with EPR had the worst OS. There were significant differences in the total-CTCs (T-CTCs) and CTCs subtypes count between the EPR group with EOR and LOR groups. Cox regression analysis indicated that the T-CTC count of > 5/5 mL, the presence of microvascular invasion (MVI) and satellite nodules were the independent risk factors for EPR. The efficiency of T-CTCs was superior as compared to those of the other indicators in predicting EPR. Moreover, the combined model demonstrated a markedly superior area under the curve (AUC). Conclusions The HCC patients with EPR had the worst OS. The preoperative CTCs was served as a prognostic indicator of EPR for HCC patients. The combined models, including T-CTCs, MVI, and satellite nodules, had the best performance to predict EPR after hepatectomy. |
| first_indexed | 2024-03-09T05:40:32Z |
| format | Article |
| id | doaj.art-c062f6176f3f4f8da988534cd776de09 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-09T05:40:32Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-c062f6176f3f4f8da988534cd776de092023-12-03T12:26:01ZengBMCBMC Cancer1471-24072023-11-0123111410.1186/s12885-023-11629-0Prognostic potential of preoperative circulating tumor cells to predict the early progression recurrence in hepatocellular carcinoma patients after hepatectomyZhan Lu0Hanghang Ni1Xihua Yang2Lihao Tan3Haixiao Zhuang4Yunning Mo5Xingyu Wei6Lunan Qi7Bangde Xiang8Department of Hepatobiliary Surgery, Guangxi Medical University Cancer HospitalDepartment of Hepatobiliary Surgery, Guangxi Medical University Cancer HospitalDepartment of Surgical Oncology, Chenzhou No. 1 People’s HospitalGuangxi Medical UniversityGuangxi Medical UniversityGuangxi Medical UniversityGuangxi Medical UniversityDepartment of Hepatobiliary Surgery, Guangxi Medical University Cancer HospitalDepartment of Hepatobiliary Surgery, Guangxi Medical University Cancer HospitalAbstract Background The role of circulating tumor cells (CTCs) in prognosis prediction has been actively studied in hepatocellular carcinoma (HCC) patients. However, their efficiency in accurately predicting early progression recurrence (EPR) is unclear. This study aimed to investigate the clinical potential of preoperative CTCs to predict EPR in HCC patients after hepatectomy. Methods One hundred forty-five HCC patients, whose preoperative CTCs were detected, were enrolled. Based on the recurrence times and types, the patients were divided into four groups, including early oligo-recurrence (EOR), EPR, late oligo-recurrence (LOR), and late progression recurrence (LPR). Results Among the 145 patients, 133 (91.7%) patients had a postoperative recurrence, including 51 EOR, 42 EPR, 39 LOR, and 1 LPR patient. Kaplan–Meier survival curve analysis indicated that the HCC patients with EPR had the worst OS. There were significant differences in the total-CTCs (T-CTCs) and CTCs subtypes count between the EPR group with EOR and LOR groups. Cox regression analysis indicated that the T-CTC count of > 5/5 mL, the presence of microvascular invasion (MVI) and satellite nodules were the independent risk factors for EPR. The efficiency of T-CTCs was superior as compared to those of the other indicators in predicting EPR. Moreover, the combined model demonstrated a markedly superior area under the curve (AUC). Conclusions The HCC patients with EPR had the worst OS. The preoperative CTCs was served as a prognostic indicator of EPR for HCC patients. The combined models, including T-CTCs, MVI, and satellite nodules, had the best performance to predict EPR after hepatectomy.https://doi.org/10.1186/s12885-023-11629-0Hepatocellular carcinomaCirculating tumor cellsHepatectomyEarly progression recurrence |
| spellingShingle | Zhan Lu Hanghang Ni Xihua Yang Lihao Tan Haixiao Zhuang Yunning Mo Xingyu Wei Lunan Qi Bangde Xiang Prognostic potential of preoperative circulating tumor cells to predict the early progression recurrence in hepatocellular carcinoma patients after hepatectomy BMC Cancer Hepatocellular carcinoma Circulating tumor cells Hepatectomy Early progression recurrence |
| title | Prognostic potential of preoperative circulating tumor cells to predict the early progression recurrence in hepatocellular carcinoma patients after hepatectomy |
| title_full | Prognostic potential of preoperative circulating tumor cells to predict the early progression recurrence in hepatocellular carcinoma patients after hepatectomy |
| title_fullStr | Prognostic potential of preoperative circulating tumor cells to predict the early progression recurrence in hepatocellular carcinoma patients after hepatectomy |
| title_full_unstemmed | Prognostic potential of preoperative circulating tumor cells to predict the early progression recurrence in hepatocellular carcinoma patients after hepatectomy |
| title_short | Prognostic potential of preoperative circulating tumor cells to predict the early progression recurrence in hepatocellular carcinoma patients after hepatectomy |
| title_sort | prognostic potential of preoperative circulating tumor cells to predict the early progression recurrence in hepatocellular carcinoma patients after hepatectomy |
| topic | Hepatocellular carcinoma Circulating tumor cells Hepatectomy Early progression recurrence |
| url | https://doi.org/10.1186/s12885-023-11629-0 |
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