The Alleviation of Dextran Sulfate Sodium (DSS)-Induced Colitis Correlate with the log<i>P</i> Values of Food-Derived Electrophilic Compounds
Food-derived electrophilic compounds (FECs) are small molecules with electrophilic groups with potential cytoprotective effects. This study investigated the differential effects of six prevalent FECs on colitis in dextran sodium sulfate (DSS)-induced mice and the underlying relationship with molecul...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/12/2406 |
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| author | Xiang-Rong Cheng Bu-Tao Yu Jie Song Jia-Hui Ma Yu-Yao Chen Chen-Xi Zhang Piao-Han Tu Mitchell N. Muskat Ze-Gang Zhu |
| author_facet | Xiang-Rong Cheng Bu-Tao Yu Jie Song Jia-Hui Ma Yu-Yao Chen Chen-Xi Zhang Piao-Han Tu Mitchell N. Muskat Ze-Gang Zhu |
| author_sort | Xiang-Rong Cheng |
| collection | DOAJ |
| description | Food-derived electrophilic compounds (FECs) are small molecules with electrophilic groups with potential cytoprotective effects. This study investigated the differential effects of six prevalent FECs on colitis in dextran sodium sulfate (DSS)-induced mice and the underlying relationship with molecular characteristics. Fumaric acid (FMA), isoliquiritigenin (ISO), cinnamaldehyde (CA), ferulic acid (FA), sulforaphane (SFN), and chlorogenic acid (CGA) exhibited varying improvements in colitis on clinical signs, colonic histopathology, inflammatory and oxidative indicators, and Nrf2 pathway in a sequence of SFN, ISO > FA, CA > FMA, CGA. Representative molecular characteristics of the “penetration-affinity–covalent binding” procedure, log<i>P</i> value, Keap1 affinity energy, and electrophilic index of FECs were theoretically calculated, among which log<i>P</i> value revealed a strong correlation with colitis improvements, which was related to the expression of Nrf2 and its downstream proteins. Above all, SFN and ISO possessed high log<i>P</i> values and effectively improving DSS-induced colitis by activating the Keap1–Nrf2 pathway to alleviate oxidative stress and inflammatory responses. |
| first_indexed | 2024-03-09T17:23:21Z |
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| id | doaj.art-c06302b9077e479fb11e3fd36054c85a |
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| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T17:23:21Z |
| publishDate | 2022-12-01 |
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| series | Antioxidants |
| spelling | doaj.art-c06302b9077e479fb11e3fd36054c85a2023-11-24T12:57:32ZengMDPI AGAntioxidants2076-39212022-12-011112240610.3390/antiox11122406The Alleviation of Dextran Sulfate Sodium (DSS)-Induced Colitis Correlate with the log<i>P</i> Values of Food-Derived Electrophilic CompoundsXiang-Rong Cheng0Bu-Tao Yu1Jie Song2Jia-Hui Ma3Yu-Yao Chen4Chen-Xi Zhang5Piao-Han Tu6Mitchell N. Muskat7Ze-Gang Zhu8School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Pharmacy, University of California San Francisco, San Francisco, CA 94143, USAJinhua Academy of Agricultural Sciences, Jinhua 321000, ChinaFood-derived electrophilic compounds (FECs) are small molecules with electrophilic groups with potential cytoprotective effects. This study investigated the differential effects of six prevalent FECs on colitis in dextran sodium sulfate (DSS)-induced mice and the underlying relationship with molecular characteristics. Fumaric acid (FMA), isoliquiritigenin (ISO), cinnamaldehyde (CA), ferulic acid (FA), sulforaphane (SFN), and chlorogenic acid (CGA) exhibited varying improvements in colitis on clinical signs, colonic histopathology, inflammatory and oxidative indicators, and Nrf2 pathway in a sequence of SFN, ISO > FA, CA > FMA, CGA. Representative molecular characteristics of the “penetration-affinity–covalent binding” procedure, log<i>P</i> value, Keap1 affinity energy, and electrophilic index of FECs were theoretically calculated, among which log<i>P</i> value revealed a strong correlation with colitis improvements, which was related to the expression of Nrf2 and its downstream proteins. Above all, SFN and ISO possessed high log<i>P</i> values and effectively improving DSS-induced colitis by activating the Keap1–Nrf2 pathway to alleviate oxidative stress and inflammatory responses.https://www.mdpi.com/2076-3921/11/12/2406electrophilic compoundcolitismolecular characteristiclog<i>P</i> |
| spellingShingle | Xiang-Rong Cheng Bu-Tao Yu Jie Song Jia-Hui Ma Yu-Yao Chen Chen-Xi Zhang Piao-Han Tu Mitchell N. Muskat Ze-Gang Zhu The Alleviation of Dextran Sulfate Sodium (DSS)-Induced Colitis Correlate with the log<i>P</i> Values of Food-Derived Electrophilic Compounds Antioxidants electrophilic compound colitis molecular characteristic log<i>P</i> |
| title | The Alleviation of Dextran Sulfate Sodium (DSS)-Induced Colitis Correlate with the log<i>P</i> Values of Food-Derived Electrophilic Compounds |
| title_full | The Alleviation of Dextran Sulfate Sodium (DSS)-Induced Colitis Correlate with the log<i>P</i> Values of Food-Derived Electrophilic Compounds |
| title_fullStr | The Alleviation of Dextran Sulfate Sodium (DSS)-Induced Colitis Correlate with the log<i>P</i> Values of Food-Derived Electrophilic Compounds |
| title_full_unstemmed | The Alleviation of Dextran Sulfate Sodium (DSS)-Induced Colitis Correlate with the log<i>P</i> Values of Food-Derived Electrophilic Compounds |
| title_short | The Alleviation of Dextran Sulfate Sodium (DSS)-Induced Colitis Correlate with the log<i>P</i> Values of Food-Derived Electrophilic Compounds |
| title_sort | alleviation of dextran sulfate sodium dss induced colitis correlate with the log i p i values of food derived electrophilic compounds |
| topic | electrophilic compound colitis molecular characteristic log<i>P</i> |
| url | https://www.mdpi.com/2076-3921/11/12/2406 |
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