Correlation of body mass index Z‐scores with glucose and lipid profiles among overweight and obese children and adolescents
Objective: To evaluate the prevalence of abnormalities in plasma lipid and glucose profiles among overweight and obese children and adolescents, and to assess the presence of a correlation between body mass index Z‐scores and indicators of comorbidities related to both profiles. Methods: This was a...
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| Format: | Article |
| Language: | Portuguese |
| Published: |
Brazilian Society of Pediatrics
2018-05-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553617301386 |
| _version_ | 1811255245505822720 |
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| author | Carlos Alberto Nogueira‐de‐Almeida Elza Daniel de Mello |
| author_facet | Carlos Alberto Nogueira‐de‐Almeida Elza Daniel de Mello |
| author_sort | Carlos Alberto Nogueira‐de‐Almeida |
| collection | DOAJ |
| description | Objective: To evaluate the prevalence of abnormalities in plasma lipid and glucose profiles among overweight and obese children and adolescents, and to assess the presence of a correlation between body mass index Z‐scores and indicators of comorbidities related to both profiles. Methods: This was a multicenter cross‐sectional study conducted at two outpatient clinics. The study included all 417 comers for the first visit from 2008 to 2012, aged between 7 and 18 years, with BMI above the Z‐score + 1. Anthropometry and blood sampling were obtained. The prevalence of dyslipidemias, hyperglycemia, and insulin resistance were evaluated, together with the correlations of these variables with the increase of Z‐BMI. Results: Dyslipidemia was observed in 43.4% of the boys and 66.1% of the girls, with no difference between genders. High glucose levels were detected in 6.2% of the individuals. Insulin resistance was present in 32.3% and 41.7% of the cases, with no statistical significance between boys and girls. Correlations between the Z‐BMI were noted for triglycerides in the entire group and among girls; for HDL‐c, only among girls; for glucose, a correlation was observed for the entire group, but not when stratified by gender. The indicators of insulin resistance were all correlated with Z‐BMI, even when corrected for age. Conclusions: Overweight and obesity give origin to a high prevalence of dyslipidemia and insulin resistance. BMI Z‐scores showed a weak positive correlation with glucose and triglyceride, and negative with HDL‐c. In turn, the strongest positive correlation was found with insulin resistance indicators. Resumo: Objetivo: Avaliar a prevalência de anormalidades nos perfis lipídico e glicêmico entre crianças e adolescentes com sobrepeso e obesidade e também verificar se existe correlação entre os escores‐z de índice de massa corporal (z‐IMC) e indicadores de comorbidades ligados a esses perfis. Métodos: Estudo de corte transversal multicêntrico, incluiu 417 pacientes entre 7 e 18 anos e IMC acima do escore‐z > + 1 que fizeram a consulta de caso novo entre 2008 e 2012. Antropometria e coleta de sangue foram realizadas. As prevalências de dislipidemia, hiperglicemia e resistência insulínica foram avaliadas, juntamente com as correlações entre essas variáveis e o z‐IMC. Resultados: Dislipidemia foi encontrada em 43,4% dos meninos e 66,1% das meninas, sem diferença entre os sexos. Hiperglicemia foi encontrada em 6,2% dos indivíduos. Resistência insulínica esteve presente entre 32,3 e 41,7% dos casos, sem diferença estatística entre os sexos. Foi observada correlação com z‐IMC para triglicerídeos quando considerado o grupo todo e entre as meninas; e para HDL‐c apenas entre as meninas. A glicemia apresentou correlação quando considerado o grupo todo, mas não quando separados por sexo. Os indicadores de resistência insulínica estiveram todos correlacionados com IMC, mesmo quando se executou correção para a idade. Conclusões: Sobrepeso e obesidade levam a prevalências elevadas de dislipidemia e resistência insulínica. Os escores‐z de IMC mostraram discreta correlação positiva com glicose e triglicerídeos e negativa com HDL‐c. Por outro lado, correlação positiva mais forte foi observada com os indicadores de resistência insulínica. Keywords: Obesity, Overweight, Dyslipidemias, Insulin Resistance, Child, Adolescent, Palavras‐chave: Obesidade, Sobrepeso, Dislipidemias, Resistência à Insulina, Criança, Adolescente |
| first_indexed | 2024-04-12T17:20:54Z |
| format | Article |
| id | doaj.art-c06455a3bc344f199e15860b7092e7b0 |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T17:20:54Z |
| publishDate | 2018-05-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-c06455a3bc344f199e15860b7092e7b02022-12-22T03:23:29ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362018-05-01943308312Correlation of body mass index Z‐scores with glucose and lipid profiles among overweight and obese children and adolescentsCarlos Alberto Nogueira‐de‐Almeida0Elza Daniel de Mello1Universidade Federal de São Carlos (UFSCAR), São Carlos, SP, Brasil; Autor para correspondência.Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Medicina, Porto Alegre, RS, BrasilObjective: To evaluate the prevalence of abnormalities in plasma lipid and glucose profiles among overweight and obese children and adolescents, and to assess the presence of a correlation between body mass index Z‐scores and indicators of comorbidities related to both profiles. Methods: This was a multicenter cross‐sectional study conducted at two outpatient clinics. The study included all 417 comers for the first visit from 2008 to 2012, aged between 7 and 18 years, with BMI above the Z‐score + 1. Anthropometry and blood sampling were obtained. The prevalence of dyslipidemias, hyperglycemia, and insulin resistance were evaluated, together with the correlations of these variables with the increase of Z‐BMI. Results: Dyslipidemia was observed in 43.4% of the boys and 66.1% of the girls, with no difference between genders. High glucose levels were detected in 6.2% of the individuals. Insulin resistance was present in 32.3% and 41.7% of the cases, with no statistical significance between boys and girls. Correlations between the Z‐BMI were noted for triglycerides in the entire group and among girls; for HDL‐c, only among girls; for glucose, a correlation was observed for the entire group, but not when stratified by gender. The indicators of insulin resistance were all correlated with Z‐BMI, even when corrected for age. Conclusions: Overweight and obesity give origin to a high prevalence of dyslipidemia and insulin resistance. BMI Z‐scores showed a weak positive correlation with glucose and triglyceride, and negative with HDL‐c. In turn, the strongest positive correlation was found with insulin resistance indicators. Resumo: Objetivo: Avaliar a prevalência de anormalidades nos perfis lipídico e glicêmico entre crianças e adolescentes com sobrepeso e obesidade e também verificar se existe correlação entre os escores‐z de índice de massa corporal (z‐IMC) e indicadores de comorbidades ligados a esses perfis. Métodos: Estudo de corte transversal multicêntrico, incluiu 417 pacientes entre 7 e 18 anos e IMC acima do escore‐z > + 1 que fizeram a consulta de caso novo entre 2008 e 2012. Antropometria e coleta de sangue foram realizadas. As prevalências de dislipidemia, hiperglicemia e resistência insulínica foram avaliadas, juntamente com as correlações entre essas variáveis e o z‐IMC. Resultados: Dislipidemia foi encontrada em 43,4% dos meninos e 66,1% das meninas, sem diferença entre os sexos. Hiperglicemia foi encontrada em 6,2% dos indivíduos. Resistência insulínica esteve presente entre 32,3 e 41,7% dos casos, sem diferença estatística entre os sexos. Foi observada correlação com z‐IMC para triglicerídeos quando considerado o grupo todo e entre as meninas; e para HDL‐c apenas entre as meninas. A glicemia apresentou correlação quando considerado o grupo todo, mas não quando separados por sexo. Os indicadores de resistência insulínica estiveram todos correlacionados com IMC, mesmo quando se executou correção para a idade. Conclusões: Sobrepeso e obesidade levam a prevalências elevadas de dislipidemia e resistência insulínica. Os escores‐z de IMC mostraram discreta correlação positiva com glicose e triglicerídeos e negativa com HDL‐c. Por outro lado, correlação positiva mais forte foi observada com os indicadores de resistência insulínica. Keywords: Obesity, Overweight, Dyslipidemias, Insulin Resistance, Child, Adolescent, Palavras‐chave: Obesidade, Sobrepeso, Dislipidemias, Resistência à Insulina, Criança, Adolescentehttp://www.sciencedirect.com/science/article/pii/S2255553617301386 |
| spellingShingle | Carlos Alberto Nogueira‐de‐Almeida Elza Daniel de Mello Correlation of body mass index Z‐scores with glucose and lipid profiles among overweight and obese children and adolescents Jornal de Pediatria (Versão em Português) |
| title | Correlation of body mass index Z‐scores with glucose and lipid profiles among overweight and obese children and adolescents |
| title_full | Correlation of body mass index Z‐scores with glucose and lipid profiles among overweight and obese children and adolescents |
| title_fullStr | Correlation of body mass index Z‐scores with glucose and lipid profiles among overweight and obese children and adolescents |
| title_full_unstemmed | Correlation of body mass index Z‐scores with glucose and lipid profiles among overweight and obese children and adolescents |
| title_short | Correlation of body mass index Z‐scores with glucose and lipid profiles among overweight and obese children and adolescents |
| title_sort | correlation of body mass index z scores with glucose and lipid profiles among overweight and obese children and adolescents |
| url | http://www.sciencedirect.com/science/article/pii/S2255553617301386 |
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