Parameter identifiability of fundamental pharmacodynamic models

Parameter identifiability of fundamental pharmacodynamic models

Issues of parameter identifiability of routinely used pharmacodynamics models are considered in this paper. The structural identifiability of 16 commonly applied pharmacodynamic model structures was analysed analytically, using the input-output approach. Both fixed-effects versions (non-population,...

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Bibliographic Details
Main Authors: Linnéa Bergenholm, David Lars Ivan Janzen, Mats Jirstrand, Joanna Parkinson, James Yates, Neil D Evans, Michael John Chappell
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Physiology
Subjects:
mixed effects models
Structural identifiability
Fixed effects models
Pharmacodynamic models
Practical parameter identifiability
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00590/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00590/full

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