Anti-Neuroinflammatory Effects of the Human Milk Oligosaccharide, 2′-Fucosyllactose, Exerted via Modulation of M2 Microglial Activation in a Mouse Model of Ischemia–Reperfusion Injury

Anti-Neuroinflammatory Effects of the Human Milk Oligosaccharide, 2′-Fucosyllactose, Exerted via Modulation of M2 Microglial Activation in a Mouse Model of Ischemia–Reperfusion Injury

Cerebral ischemic stroke is one of the leading causes of death and disability worldwide. 2′-fucosyllactose (2′-FL), a human milk oligosaccharide, exerts anti-inflammatory effects and plays a protective role in arterial thrombosis; however, its role in ischemic stroke remains unclear. This study aime...

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Bibliographic Details
Main Authors: Malk Eun Pak, Yeon-Ji Kim, Hanhae Kim, Chul Soo Shin, Jong-Won Yoon, Seon-min Jeon, Young-Ha Song, Kyungho Kim
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Antioxidants
Subjects:
2′-fucosyllactose
microglia polarization
neuroinflammation
reactive oxygen species
ischemic injury
Online Access:https://www.mdpi.com/2076-3921/12/6/1281

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