Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis
Aim: Hyperuricemia as a putative risk factor for chronic kidney disease (CKD) progression remains controversial and debatable. This systematic review aims to explore the prevalence of hyperuricemia among CKD patients worldwide. Methods: This study was conducted in accordance with the Meta-analysi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2022-06-01
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| Series: | Exploration of Medicine |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/em/Article/100189 |
| _version_ | 1818244618280501248 |
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| author | Ishfaq Rashid Pooja Katravath Pramil Tiwari Sanjay D’Cruz Shivani Jaswal Gautam Sahu |
| author_facet | Ishfaq Rashid Pooja Katravath Pramil Tiwari Sanjay D’Cruz Shivani Jaswal Gautam Sahu |
| author_sort | Ishfaq Rashid |
| collection | DOAJ |
| description | Aim:
Hyperuricemia as a putative risk factor for chronic kidney disease (CKD) progression remains controversial and debatable. This systematic review aims to explore the prevalence of hyperuricemia among CKD patients worldwide.
Methods:
This study was conducted in accordance with the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines by using the existing literature from online databases such as MEDLINE/PubMed, ScienceDirect, Google Scholar, Cochrane library and grey literature. The effect size with corresponding 95% confidence interval (CI) was calculated to assess the pooled prevalence of hyperuricemia in chronic kidney patients. The subgroup analysis based on gender and geography was also carried out by utilizing comprehensive meta-analysis, version 2.0.
Results:
Twenty-three studies containing 212,740 participants were eligible for quantitative synthesis. The pooled prevalence of 43.6% (35.2–52.4%) hyperuricemia was reported in patients with CKD globally. In India, 38.4% of prevalence was observed. The gender specific prevalence (9 studies) was reported as 67.4% (60.9–73.3%) in case of male patients and 32.6% (26.7–39.1%) in female patients with 95% CI.
Conclusions:
The prevalence of hyperuricemia was reported to be reasonably high among CKD patients worldwide. During the management of CKD, this high prevalence demands more prudent attention for this clinical complication which possibly can lead to positive renal outcomes. |
| first_indexed | 2024-12-12T14:19:53Z |
| format | Article |
| id | doaj.art-c066ed92df854e0080002e1834d81d66 |
| institution | Directory Open Access Journal |
| issn | 2692-3106 |
| language | English |
| last_indexed | 2024-12-12T14:19:53Z |
| publishDate | 2022-06-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj.art-c066ed92df854e0080002e1834d81d662022-12-22T00:21:49ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062022-06-013324925910.37349/emed.2022.00089Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysisIshfaq Rashid0https://orcid.org/0000-0001-8816-3987Pooja Katravath1Pramil Tiwari2https://orcid.org/0000-0003-0442-7880Sanjay D’Cruz3https://orcid.org/0000-0001-8831-8002Shivani Jaswal4Gautam Sahu5Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab 160062, IndiaDepartment of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab 160062, IndiaDepartment of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab 160062, IndiaDepartment of General Medicine, Government Medical College and Hospital, Chandigarh 160030, IndiaDepartment of Biochemistry, Government Medical College and Hospital, Chandigarh 160030, IndiaDepartment of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab 160062, IndiaAim: Hyperuricemia as a putative risk factor for chronic kidney disease (CKD) progression remains controversial and debatable. This systematic review aims to explore the prevalence of hyperuricemia among CKD patients worldwide. Methods: This study was conducted in accordance with the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines by using the existing literature from online databases such as MEDLINE/PubMed, ScienceDirect, Google Scholar, Cochrane library and grey literature. The effect size with corresponding 95% confidence interval (CI) was calculated to assess the pooled prevalence of hyperuricemia in chronic kidney patients. The subgroup analysis based on gender and geography was also carried out by utilizing comprehensive meta-analysis, version 2.0. Results: Twenty-three studies containing 212,740 participants were eligible for quantitative synthesis. The pooled prevalence of 43.6% (35.2–52.4%) hyperuricemia was reported in patients with CKD globally. In India, 38.4% of prevalence was observed. The gender specific prevalence (9 studies) was reported as 67.4% (60.9–73.3%) in case of male patients and 32.6% (26.7–39.1%) in female patients with 95% CI. Conclusions: The prevalence of hyperuricemia was reported to be reasonably high among CKD patients worldwide. During the management of CKD, this high prevalence demands more prudent attention for this clinical complication which possibly can lead to positive renal outcomes. https://www.explorationpub.com/Journals/em/Article/100189hyperuricemiachronic kidney diseaseprevalencegeographyuric acid |
| spellingShingle | Ishfaq Rashid Pooja Katravath Pramil Tiwari Sanjay D’Cruz Shivani Jaswal Gautam Sahu Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis Exploration of Medicine hyperuricemia chronic kidney disease prevalence geography uric acid |
| title | Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis |
| title_full | Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis |
| title_fullStr | Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis |
| title_full_unstemmed | Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis |
| title_short | Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis |
| title_sort | hyperuricemia a serious complication among patients with chronic kidney disease a systematic review and meta analysis |
| topic | hyperuricemia chronic kidney disease prevalence geography uric acid |
| url | https://www.explorationpub.com/Journals/em/Article/100189 |
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