Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease causing axonal degeneration and demyelination. Exercise in mice with active monophasic experimental autoimmune encephalomyelitis (EAE) attenuates disease severity associated with diverse impacts on T cell-mediated immunity. However...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/21/15798 |
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| author | Daniel Schiffmann Victoria Lampkemeyer Maren Lindner Ann-Katrin Fleck Kathrin Koch Melanie Eschborn Marie Liebmann Jan-Kolja Strecker Jens Minnerup Heinz Wiendl Luisa Klotz |
| author_facet | Daniel Schiffmann Victoria Lampkemeyer Maren Lindner Ann-Katrin Fleck Kathrin Koch Melanie Eschborn Marie Liebmann Jan-Kolja Strecker Jens Minnerup Heinz Wiendl Luisa Klotz |
| author_sort | Daniel Schiffmann |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease causing axonal degeneration and demyelination. Exercise in mice with active monophasic experimental autoimmune encephalomyelitis (EAE) attenuates disease severity associated with diverse impacts on T cell-mediated immunity. However, studies have so far focused on preventive approaches. In this study, we investigated the impact of endurance exercise on established EAE disease in a model of secondary progressive MS. When the exercise program on motorized running wheels was started at disease manifestation, the disease course was significantly ameliorated. This was associated with a significant decrease in B cell, dendritic cell, and neutrophil cell counts in the central nervous system (CNS). Furthermore, we observed an increased expression of major histocompatibility complex class II (MHC-II) as well as alterations in costimulatory molecule expression in CNS B cells and dendritic cells. In contrast, T cell responses were not altered in the CNS or periphery. Thus, exercise training is capable of attenuating the disease course even in established secondary progressive EAE, potentially via modulation of the innate immune compartment. Further studies are warranted to corroborate our findings and assess the potential of this lifestyle intervention as a complementary therapeutic strategy in secondary progressive MS patients. |
| first_indexed | 2024-03-11T11:29:04Z |
| format | Article |
| id | doaj.art-c068d9a7c46049fab23d35d4faf9a040 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T11:29:04Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c068d9a7c46049fab23d35d4faf9a0402023-11-10T15:05:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124211579810.3390/ijms242115798Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD MiceDaniel Schiffmann0Victoria Lampkemeyer1Maren Lindner2Ann-Katrin Fleck3Kathrin Koch4Melanie Eschborn5Marie Liebmann6Jan-Kolja Strecker7Jens Minnerup8Heinz Wiendl9Luisa Klotz10Department of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, GermanyMultiple sclerosis (MS) is a chronic inflammatory autoimmune disease causing axonal degeneration and demyelination. Exercise in mice with active monophasic experimental autoimmune encephalomyelitis (EAE) attenuates disease severity associated with diverse impacts on T cell-mediated immunity. However, studies have so far focused on preventive approaches. In this study, we investigated the impact of endurance exercise on established EAE disease in a model of secondary progressive MS. When the exercise program on motorized running wheels was started at disease manifestation, the disease course was significantly ameliorated. This was associated with a significant decrease in B cell, dendritic cell, and neutrophil cell counts in the central nervous system (CNS). Furthermore, we observed an increased expression of major histocompatibility complex class II (MHC-II) as well as alterations in costimulatory molecule expression in CNS B cells and dendritic cells. In contrast, T cell responses were not altered in the CNS or periphery. Thus, exercise training is capable of attenuating the disease course even in established secondary progressive EAE, potentially via modulation of the innate immune compartment. Further studies are warranted to corroborate our findings and assess the potential of this lifestyle intervention as a complementary therapeutic strategy in secondary progressive MS patients.https://www.mdpi.com/1422-0067/24/21/15798experimental autoimmune encephalomyelitismultiple sclerosisautoimmunitycentral nervous systemexerciselifestyle intervention |
| spellingShingle | Daniel Schiffmann Victoria Lampkemeyer Maren Lindner Ann-Katrin Fleck Kathrin Koch Melanie Eschborn Marie Liebmann Jan-Kolja Strecker Jens Minnerup Heinz Wiendl Luisa Klotz Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice International Journal of Molecular Sciences experimental autoimmune encephalomyelitis multiple sclerosis autoimmunity central nervous system exercise lifestyle intervention |
| title | Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice |
| title_full | Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice |
| title_fullStr | Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice |
| title_full_unstemmed | Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice |
| title_short | Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice |
| title_sort | endurance exercise attenuates established progressive experimental autoimmune encephalomyelitis and is associated with an amelioration of innate immune responses in nod mice |
| topic | experimental autoimmune encephalomyelitis multiple sclerosis autoimmunity central nervous system exercise lifestyle intervention |
| url | https://www.mdpi.com/1422-0067/24/21/15798 |
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