Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA
Background and Objectives: Alterations in CXCL10 (a Th1 chemokine) expression have been associated with various diseases. The aim of this study was to evaluate the serum CXCL10 levels in H. pylori-infected patients with peptic ulcer (PU), H. pylori-infected asymptomatic (AS) subjects and healthy H....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2013-03-01
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| Series: | Iranian Journal of Microbiology |
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| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/640 |
| _version_ | 1818389539264135168 |
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| author | Abdollah Jafarzadeh Maryam Nemati Mohammad-Taghi Rezayati Hossain Khoramdel Mansooreh Nabizadeh Gholamhossain Hassanshahi Hamid Abdollahi |
| author_facet | Abdollah Jafarzadeh Maryam Nemati Mohammad-Taghi Rezayati Hossain Khoramdel Mansooreh Nabizadeh Gholamhossain Hassanshahi Hamid Abdollahi |
| author_sort | Abdollah Jafarzadeh |
| collection | DOAJ |
| description | Background and Objectives: Alterations in CXCL10 (a Th1 chemokine) expression have been associated with various diseases. The aim of this study was to evaluate the serum CXCL10 levels in H. pylori-infected patients with peptic ulcer (PU), H. pylori-infected asymptomatic (AS) subjects and healthy H. pylori-negative subjects, and also to determine its association with bacterial virulence factor cytotoxin-associated gene A (CagA).
Materials and Methods: Serum samples from 90 H. pylori infected patients with PU (70 were anti-CagA+, 20 were anti- CagA-), 65 AS carriers (40 were anti-CagA+, 25 were anti-CagA-) and 30 healthy H. pylori-negative subjects (as a control group) were tested for concentrations of CXCL10 by using the ELISA method.
Results: The mean serum levels of CXCL10 in PU patients (96.64 ± 20.85 pg/mL) were significantly lower than those observed in AS subjects (162.16 ± 53.31 pg/mL, P < 0.01) and the control group (193.93 ± 42.14 pg/mL, P < 0.02). In the PU group, the serum levels of CXCL10 in anti-CagA+ subjects was significantly higher in comparison to anti-CagA- patients (P < 0.04).
Conclusion: These results showed that the mean concentrations of CXCL10 in H. pylori-infected-PU patients was lower than AS carriers and control group. In the PU group, the serum levels of CXCL10 were associated with bacterial factor CagA. |
| first_indexed | 2024-12-14T04:43:20Z |
| format | Article |
| id | doaj.art-c06bbebb7dc54d2d94fdcdb2bae31686 |
| institution | Directory Open Access Journal |
| issn | 2008-3289 2008-4447 |
| language | English |
| last_indexed | 2024-12-14T04:43:20Z |
| publishDate | 2013-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj.art-c06bbebb7dc54d2d94fdcdb2bae316862022-12-21T23:16:45ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472013-03-0151Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagAAbdollah Jafarzadeh0Maryam Nemati1Mohammad-Taghi Rezayati2Hossain Khoramdel3Mansooreh Nabizadeh4Gholamhossain Hassanshahi5Hamid Abdollahi6Department of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AND Immunology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AND Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.Department of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.Department of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.Immunology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.Department of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.Immunology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.Department of Microbiology and Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran.Background and Objectives: Alterations in CXCL10 (a Th1 chemokine) expression have been associated with various diseases. The aim of this study was to evaluate the serum CXCL10 levels in H. pylori-infected patients with peptic ulcer (PU), H. pylori-infected asymptomatic (AS) subjects and healthy H. pylori-negative subjects, and also to determine its association with bacterial virulence factor cytotoxin-associated gene A (CagA). Materials and Methods: Serum samples from 90 H. pylori infected patients with PU (70 were anti-CagA+, 20 were anti- CagA-), 65 AS carriers (40 were anti-CagA+, 25 were anti-CagA-) and 30 healthy H. pylori-negative subjects (as a control group) were tested for concentrations of CXCL10 by using the ELISA method. Results: The mean serum levels of CXCL10 in PU patients (96.64 ± 20.85 pg/mL) were significantly lower than those observed in AS subjects (162.16 ± 53.31 pg/mL, P < 0.01) and the control group (193.93 ± 42.14 pg/mL, P < 0.02). In the PU group, the serum levels of CXCL10 in anti-CagA+ subjects was significantly higher in comparison to anti-CagA- patients (P < 0.04). Conclusion: These results showed that the mean concentrations of CXCL10 in H. pylori-infected-PU patients was lower than AS carriers and control group. In the PU group, the serum levels of CXCL10 were associated with bacterial factor CagA.https://ijm.tums.ac.ir/index.php/ijm/article/view/640Anti-CagAChemokine CXCL10Helicobacter pyloriIranKerman ProvincePeptic Ulcer |
| spellingShingle | Abdollah Jafarzadeh Maryam Nemati Mohammad-Taghi Rezayati Hossain Khoramdel Mansooreh Nabizadeh Gholamhossain Hassanshahi Hamid Abdollahi Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA Iranian Journal of Microbiology Anti-CagA Chemokine CXCL10 Helicobacter pylori Iran Kerman Province Peptic Ulcer |
| title | Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA |
| title_full | Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA |
| title_fullStr | Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA |
| title_full_unstemmed | Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA |
| title_short | Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA |
| title_sort | lower circulating levels of chemokine cxcl10 in helicobacter pylori infected patients with peptic ulcer influence of the bacterial virulence factor caga |
| topic | Anti-CagA Chemokine CXCL10 Helicobacter pylori Iran Kerman Province Peptic Ulcer |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/640 |
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