Strong Antimicrobial Activity of Highly Stable Nanocomposite Containing AgNPs Based on Water-Soluble Triazole-Sulfonate Copolymer
A new hydrophilic polymeric nanocomposite containing AgNPs was synthesized by chemical reduction of metal ions in an aqueous medium in the presence of the copolymer. A new water-soluble copolymer of 1-vinyl-1,2,4-triazole and vinylsulfonic acid sodium salt (poly(VT-co-Na-VSA)) was obtained by free-r...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/1/206 |
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| author | Alexander Pozdnyakov Artem Emel’yanov Anastasiya Ivanova Nadezhda Kuznetsova Tat’yana Semenova Yuliya Bolgova Svetlana Korzhova Olga Trofimova Tat’yana Fadeeva Galina Prozorova |
| author_facet | Alexander Pozdnyakov Artem Emel’yanov Anastasiya Ivanova Nadezhda Kuznetsova Tat’yana Semenova Yuliya Bolgova Svetlana Korzhova Olga Trofimova Tat’yana Fadeeva Galina Prozorova |
| author_sort | Alexander Pozdnyakov |
| collection | DOAJ |
| description | A new hydrophilic polymeric nanocomposite containing AgNPs was synthesized by chemical reduction of metal ions in an aqueous medium in the presence of the copolymer. A new water-soluble copolymer of 1-vinyl-1,2,4-triazole and vinylsulfonic acid sodium salt (poly(VT-co-Na-VSA)) was obtained by free-radical copolymerization and was used as a stabilizing precursor agent. The structural, dimensional, and morphological properties of the nanocomposite were studied by UV–Vis, FTIR, X-ray diffraction, atomic absorption, transmission and scanning electron microscopy, dynamic and electrophoretic light scattering, gel permeation chromatography, thermogravimetric analysis, and differential scanning calorimetry. Hydrodynamic diameter of macroclubs for the copolymer was 171 nm, and for the nanocomposite it was 694 nm. Zeta potential for the copolymer was −63.8 mV, and for the nanocomposite it was −70.4 mV. The nanocomposite had strong antimicrobial activity towards Gram-negative and Gram-positive microorganisms: MIC and MBC values were in the range of 0.25–4.0 and 0.5–8.0 μg/mL, respectively. |
| first_indexed | 2024-03-10T00:42:19Z |
| format | Article |
| id | doaj.art-c073bfe48ae144e3aaf1411b8f3b780a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T00:42:19Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-c073bfe48ae144e3aaf1411b8f3b780a2023-11-23T15:05:37ZengMDPI AGPharmaceutics1999-49232022-01-0114120610.3390/pharmaceutics14010206Strong Antimicrobial Activity of Highly Stable Nanocomposite Containing AgNPs Based on Water-Soluble Triazole-Sulfonate CopolymerAlexander Pozdnyakov0Artem Emel’yanov1Anastasiya Ivanova2Nadezhda Kuznetsova3Tat’yana Semenova4Yuliya Bolgova5Svetlana Korzhova6Olga Trofimova7Tat’yana Fadeeva8Galina Prozorova9A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, RussiaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, RussiaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, RussiaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, RussiaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, RussiaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, RussiaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, RussiaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, RussiaIrkutsk Scientific Center of Surgery and Traumatology, 664003 Irkutsk, RussiaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, RussiaA new hydrophilic polymeric nanocomposite containing AgNPs was synthesized by chemical reduction of metal ions in an aqueous medium in the presence of the copolymer. A new water-soluble copolymer of 1-vinyl-1,2,4-triazole and vinylsulfonic acid sodium salt (poly(VT-co-Na-VSA)) was obtained by free-radical copolymerization and was used as a stabilizing precursor agent. The structural, dimensional, and morphological properties of the nanocomposite were studied by UV–Vis, FTIR, X-ray diffraction, atomic absorption, transmission and scanning electron microscopy, dynamic and electrophoretic light scattering, gel permeation chromatography, thermogravimetric analysis, and differential scanning calorimetry. Hydrodynamic diameter of macroclubs for the copolymer was 171 nm, and for the nanocomposite it was 694 nm. Zeta potential for the copolymer was −63.8 mV, and for the nanocomposite it was −70.4 mV. The nanocomposite had strong antimicrobial activity towards Gram-negative and Gram-positive microorganisms: MIC and MBC values were in the range of 0.25–4.0 and 0.5–8.0 μg/mL, respectively.https://www.mdpi.com/1999-4923/14/1/206hydrophilic nanocompositeantimicrobial activitysilver nanoparticles1-vinyl-1,2,4-triazolevinylsulfonic acid sodium salt |
| spellingShingle | Alexander Pozdnyakov Artem Emel’yanov Anastasiya Ivanova Nadezhda Kuznetsova Tat’yana Semenova Yuliya Bolgova Svetlana Korzhova Olga Trofimova Tat’yana Fadeeva Galina Prozorova Strong Antimicrobial Activity of Highly Stable Nanocomposite Containing AgNPs Based on Water-Soluble Triazole-Sulfonate Copolymer Pharmaceutics hydrophilic nanocomposite antimicrobial activity silver nanoparticles 1-vinyl-1,2,4-triazole vinylsulfonic acid sodium salt |
| title | Strong Antimicrobial Activity of Highly Stable Nanocomposite Containing AgNPs Based on Water-Soluble Triazole-Sulfonate Copolymer |
| title_full | Strong Antimicrobial Activity of Highly Stable Nanocomposite Containing AgNPs Based on Water-Soluble Triazole-Sulfonate Copolymer |
| title_fullStr | Strong Antimicrobial Activity of Highly Stable Nanocomposite Containing AgNPs Based on Water-Soluble Triazole-Sulfonate Copolymer |
| title_full_unstemmed | Strong Antimicrobial Activity of Highly Stable Nanocomposite Containing AgNPs Based on Water-Soluble Triazole-Sulfonate Copolymer |
| title_short | Strong Antimicrobial Activity of Highly Stable Nanocomposite Containing AgNPs Based on Water-Soluble Triazole-Sulfonate Copolymer |
| title_sort | strong antimicrobial activity of highly stable nanocomposite containing agnps based on water soluble triazole sulfonate copolymer |
| topic | hydrophilic nanocomposite antimicrobial activity silver nanoparticles 1-vinyl-1,2,4-triazole vinylsulfonic acid sodium salt |
| url | https://www.mdpi.com/1999-4923/14/1/206 |
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