Intestinal Barrier, Permeability and Nonspecific Inflammation in Functional Gastrointestinal Disorders
Aim of review. Description of intestinal mucosal barrier permeability disruption causes as morbid factors in gastrointestinal tract (GIT) functional disorders.General provisions. Intestinal mucosal barrier is composed of several elements: pre-epithelial barrier, a mucosal lining of epithelium; epith...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2020-09-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/437 |
| _version_ | 1797245219639394304 |
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| author | A. L. Kovaleva E. A. Poluektova O. S. Shifrin |
| author_facet | A. L. Kovaleva E. A. Poluektova O. S. Shifrin |
| author_sort | A. L. Kovaleva |
| collection | DOAJ |
| description | Aim of review. Description of intestinal mucosal barrier permeability disruption causes as morbid factors in gastrointestinal tract (GIT) functional disorders.General provisions. Intestinal mucosal barrier is composed of several elements: pre-epithelial barrier, a mucosal lining of epithelium; epithelial barrier that leverages tight junctional structures and high regenerative capacity of epithelium; post-epithelial barrier established by immune cells and blood vessels. Gut microbiota profile may also be constituent of the intestinal mucosal barrier. Functional dyspepsia (FD) and irritable bowel syndrome (IBS) leave distinct morphological imprint. For instance, FD patients exhibit variant expression of cell junction proteins (claudin-1, zonula occludens, occludin, E-cadherin, β-catenin and desmoglein-2), and IBS patients — overexpression of claudin-2. Permeability disruption leads to inflammatory changes in intestinal wall resulting in visceral and central sensitisation, as well as intestinal motor dysfunctions causal of IBS and FD.Conclusion. Disruption of intestinal mucosal barrier may be considered a pathogenetic factor of PD and IBS progression. |
| first_indexed | 2024-03-08T09:21:21Z |
| format | Article |
| id | doaj.art-c074477bc63b4daa997981ec6791eee1 |
| institution | Directory Open Access Journal |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| last_indexed | 2024-04-24T19:23:26Z |
| publishDate | 2020-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj.art-c074477bc63b4daa997981ec6791eee12024-03-25T16:53:09ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732020-09-01304525910.22416/1382-4376-2020-30-4-52-59375Intestinal Barrier, Permeability and Nonspecific Inflammation in Functional Gastrointestinal DisordersA. L. Kovaleva0E. A. Poluektova1O. S. Shifrin2Sechenov First Moscow State University (Sechenov University)Sechenov First Moscow State University (Sechenov University)Sechenov First Moscow State University (Sechenov University)Aim of review. Description of intestinal mucosal barrier permeability disruption causes as morbid factors in gastrointestinal tract (GIT) functional disorders.General provisions. Intestinal mucosal barrier is composed of several elements: pre-epithelial barrier, a mucosal lining of epithelium; epithelial barrier that leverages tight junctional structures and high regenerative capacity of epithelium; post-epithelial barrier established by immune cells and blood vessels. Gut microbiota profile may also be constituent of the intestinal mucosal barrier. Functional dyspepsia (FD) and irritable bowel syndrome (IBS) leave distinct morphological imprint. For instance, FD patients exhibit variant expression of cell junction proteins (claudin-1, zonula occludens, occludin, E-cadherin, β-catenin and desmoglein-2), and IBS patients — overexpression of claudin-2. Permeability disruption leads to inflammatory changes in intestinal wall resulting in visceral and central sensitisation, as well as intestinal motor dysfunctions causal of IBS and FD.Conclusion. Disruption of intestinal mucosal barrier may be considered a pathogenetic factor of PD and IBS progression.https://www.gastro-j.ru/jour/article/view/437irritable bowel syndromefunctional dyspepsiaintestinal mucosal barrierintestinal permeability conflict of interest: the authors declare no conflict of interest |
| spellingShingle | A. L. Kovaleva E. A. Poluektova O. S. Shifrin Intestinal Barrier, Permeability and Nonspecific Inflammation in Functional Gastrointestinal Disorders Российский журнал гастроэнтерологии, гепатологии, колопроктологии irritable bowel syndrome functional dyspepsia intestinal mucosal barrier intestinal permeability conflict of interest: the authors declare no conflict of interest |
| title | Intestinal Barrier, Permeability and Nonspecific Inflammation in Functional Gastrointestinal Disorders |
| title_full | Intestinal Barrier, Permeability and Nonspecific Inflammation in Functional Gastrointestinal Disorders |
| title_fullStr | Intestinal Barrier, Permeability and Nonspecific Inflammation in Functional Gastrointestinal Disorders |
| title_full_unstemmed | Intestinal Barrier, Permeability and Nonspecific Inflammation in Functional Gastrointestinal Disorders |
| title_short | Intestinal Barrier, Permeability and Nonspecific Inflammation in Functional Gastrointestinal Disorders |
| title_sort | intestinal barrier permeability and nonspecific inflammation in functional gastrointestinal disorders |
| topic | irritable bowel syndrome functional dyspepsia intestinal mucosal barrier intestinal permeability conflict of interest: the authors declare no conflict of interest |
| url | https://www.gastro-j.ru/jour/article/view/437 |
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