Does serum 25-hydroxyvitamin D influence muscle development during puberty in girls? A 7-year longitudinal study.
Vitamin D is well known for its regulatory role in calcium and phosphate homeostasis, but its role in muscle mass and strength during growth remains inconclusive. We explored the association of serum 25-hydroxyvitamin D (25(OH)D) with muscle development in girls from 11 to 18-years old. Whole body l...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3864869?pdf=render |
| _version_ | 1828186218451435520 |
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| author | Ru Wang Markku Alen Zhusheng Yu Petri Wiklund Shu Mei Cheng Timo Törmäkangas Peijie Chen Sulin Cheng |
| author_facet | Ru Wang Markku Alen Zhusheng Yu Petri Wiklund Shu Mei Cheng Timo Törmäkangas Peijie Chen Sulin Cheng |
| author_sort | Ru Wang |
| collection | DOAJ |
| description | Vitamin D is well known for its regulatory role in calcium and phosphate homeostasis, but its role in muscle mass and strength during growth remains inconclusive. We explored the association of serum 25-hydroxyvitamin D (25(OH)D) with muscle development in girls from 11 to 18-years old. Whole body lean tissue mass (LMWB), appendicular lean mass (aLM), muscle cross-sectional area at the lower leg (mCSA), maximal voluntary contraction of elbow flexors (MVC elbow) and knee extensors (MVC knee) were assessed in 217 girls aged 10-13 years (at baseline), 215 in 2-year and 226 in 7.5-year follow-up. Serum concentration of 25(OH)D and intact parathyroid hormone (PTH) were analyzed retrospectively and girls were categorized according to their 25(OH)D levels (consistently insufficient 25(OH)D GLL <50 nmol/l and consistently sufficient GHH >50 nmol/l from baseline to 7-year follow-up). We found that 25(OH)D level declined until menarche (p<0.05) while LMWB, aLM, mCSA, MVC elbow and MVC knee continued to increase (p<0.001 for all) post menarche. At pre-menarche, the GLL (n = 34) had higher LMWB and aLM than the GHH (n = 21, p<0.05), while post-menarche the GHH (n = 15) had a greater catch-up gain in LMWB (p = 0.004), aLM (p = 0.001) and mCSA (p = 0.027) compared to the GLL (n = 65) over the first 2-year period. At the age of 18, no differences in muscle mass/strength between the low (n = 151) and high (n = 77) levels of 25(OH)D groups were found. This finding was independent of vitamin D receptor genotype and other confounders. In conclusion, our results showed that levels of 25(OH)D have no significant negative influence on the development of muscle mass and strength during pubertal growth both with longitudinal and cross-sectional comparison. On the contrary, our results suggest that the temporary negative association between 25(OH)D and muscle mass arises as a consequence of fast growth prior to menarche, and this negative association is diminished through catch-up growth after menarche. |
| first_indexed | 2024-04-12T07:15:17Z |
| format | Article |
| id | doaj.art-c0748c2242374147a611cfe15eab6222 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T07:15:17Z |
| publishDate | 2013-01-01 |
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| spelling | doaj.art-c0748c2242374147a611cfe15eab62222022-12-22T03:42:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8212410.1371/journal.pone.0082124Does serum 25-hydroxyvitamin D influence muscle development during puberty in girls? A 7-year longitudinal study.Ru WangMarkku AlenZhusheng YuPetri WiklundShu Mei ChengTimo TörmäkangasPeijie ChenSulin ChengVitamin D is well known for its regulatory role in calcium and phosphate homeostasis, but its role in muscle mass and strength during growth remains inconclusive. We explored the association of serum 25-hydroxyvitamin D (25(OH)D) with muscle development in girls from 11 to 18-years old. Whole body lean tissue mass (LMWB), appendicular lean mass (aLM), muscle cross-sectional area at the lower leg (mCSA), maximal voluntary contraction of elbow flexors (MVC elbow) and knee extensors (MVC knee) were assessed in 217 girls aged 10-13 years (at baseline), 215 in 2-year and 226 in 7.5-year follow-up. Serum concentration of 25(OH)D and intact parathyroid hormone (PTH) were analyzed retrospectively and girls were categorized according to their 25(OH)D levels (consistently insufficient 25(OH)D GLL <50 nmol/l and consistently sufficient GHH >50 nmol/l from baseline to 7-year follow-up). We found that 25(OH)D level declined until menarche (p<0.05) while LMWB, aLM, mCSA, MVC elbow and MVC knee continued to increase (p<0.001 for all) post menarche. At pre-menarche, the GLL (n = 34) had higher LMWB and aLM than the GHH (n = 21, p<0.05), while post-menarche the GHH (n = 15) had a greater catch-up gain in LMWB (p = 0.004), aLM (p = 0.001) and mCSA (p = 0.027) compared to the GLL (n = 65) over the first 2-year period. At the age of 18, no differences in muscle mass/strength between the low (n = 151) and high (n = 77) levels of 25(OH)D groups were found. This finding was independent of vitamin D receptor genotype and other confounders. In conclusion, our results showed that levels of 25(OH)D have no significant negative influence on the development of muscle mass and strength during pubertal growth both with longitudinal and cross-sectional comparison. On the contrary, our results suggest that the temporary negative association between 25(OH)D and muscle mass arises as a consequence of fast growth prior to menarche, and this negative association is diminished through catch-up growth after menarche.http://europepmc.org/articles/PMC3864869?pdf=render |
| spellingShingle | Ru Wang Markku Alen Zhusheng Yu Petri Wiklund Shu Mei Cheng Timo Törmäkangas Peijie Chen Sulin Cheng Does serum 25-hydroxyvitamin D influence muscle development during puberty in girls? A 7-year longitudinal study. PLoS ONE |
| title | Does serum 25-hydroxyvitamin D influence muscle development during puberty in girls? A 7-year longitudinal study. |
| title_full | Does serum 25-hydroxyvitamin D influence muscle development during puberty in girls? A 7-year longitudinal study. |
| title_fullStr | Does serum 25-hydroxyvitamin D influence muscle development during puberty in girls? A 7-year longitudinal study. |
| title_full_unstemmed | Does serum 25-hydroxyvitamin D influence muscle development during puberty in girls? A 7-year longitudinal study. |
| title_short | Does serum 25-hydroxyvitamin D influence muscle development during puberty in girls? A 7-year longitudinal study. |
| title_sort | does serum 25 hydroxyvitamin d influence muscle development during puberty in girls a 7 year longitudinal study |
| url | http://europepmc.org/articles/PMC3864869?pdf=render |
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