Isolated Horizontal Gaze Palsy: Observations and Explanations
We present three cases that we suggest require a novel diagnosis and a reconsideration of current understandings of pontine anatomy. In this case series, we highlight a series of patients with monophasic, fully recovering inflammatory lesions in the pontine tegmentum not due to any of the currently...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00611/full |
| _version_ | 1828909601893908480 |
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| author | Renee Ewe Owen B. White Owen B. White Ailbhe Burke |
| author_facet | Renee Ewe Owen B. White Owen B. White Ailbhe Burke |
| author_sort | Renee Ewe |
| collection | DOAJ |
| description | We present three cases that we suggest require a novel diagnosis and a reconsideration of current understandings of pontine anatomy. In this case series, we highlight a series of patients with monophasic, fully recovering inflammatory lesions in the pontine tegmentum not due to any of the currently recognized causes of this syndrome. We highlight other similar cases in the literature and suggest there may be a particular epitope for an as-yet-undiscovered antibody underlying the tropism for this area. We highlight the potential harm of misdiagnosis with relapsing inflammatory or other serious diagnoses with significant adverse impact on the patient. In addition, we propose that this would support a reinterpretation of the currently accepted anatomy of the pontine gaze inputs to the median longitudinal fasciculus and paramedian pontine reticular formation. |
| first_indexed | 2024-12-13T18:29:48Z |
| format | Article |
| id | doaj.art-c075ee7b275844d78839173570edb2bd |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-13T18:29:48Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-c075ee7b275844d78839173570edb2bd2022-12-21T23:35:30ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-11-01810.3389/fneur.2017.00611300960Isolated Horizontal Gaze Palsy: Observations and ExplanationsRenee Ewe0Owen B. White1Owen B. White2Ailbhe Burke3Whittington Hospital, London, United KingdomDepartment of Neurology, Royal Melbourne Hospital, Parkville, VIC, AustraliaDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, AustraliaThe National Hospital for Nervous Diseases, London, United KingdomWe present three cases that we suggest require a novel diagnosis and a reconsideration of current understandings of pontine anatomy. In this case series, we highlight a series of patients with monophasic, fully recovering inflammatory lesions in the pontine tegmentum not due to any of the currently recognized causes of this syndrome. We highlight other similar cases in the literature and suggest there may be a particular epitope for an as-yet-undiscovered antibody underlying the tropism for this area. We highlight the potential harm of misdiagnosis with relapsing inflammatory or other serious diagnoses with significant adverse impact on the patient. In addition, we propose that this would support a reinterpretation of the currently accepted anatomy of the pontine gaze inputs to the median longitudinal fasciculus and paramedian pontine reticular formation.http://journal.frontiersin.org/article/10.3389/fneur.2017.00611/fullophthalmoplegiahorizontal gazepontine anatomyparamedian pontine reticular formationmedian longitudinal fasciculus |
| spellingShingle | Renee Ewe Owen B. White Owen B. White Ailbhe Burke Isolated Horizontal Gaze Palsy: Observations and Explanations Frontiers in Neurology ophthalmoplegia horizontal gaze pontine anatomy paramedian pontine reticular formation median longitudinal fasciculus |
| title | Isolated Horizontal Gaze Palsy: Observations and Explanations |
| title_full | Isolated Horizontal Gaze Palsy: Observations and Explanations |
| title_fullStr | Isolated Horizontal Gaze Palsy: Observations and Explanations |
| title_full_unstemmed | Isolated Horizontal Gaze Palsy: Observations and Explanations |
| title_short | Isolated Horizontal Gaze Palsy: Observations and Explanations |
| title_sort | isolated horizontal gaze palsy observations and explanations |
| topic | ophthalmoplegia horizontal gaze pontine anatomy paramedian pontine reticular formation median longitudinal fasciculus |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2017.00611/full |
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