pH-Dependent Specificity of Papain-Like Cysteine Proteases Is Determined by S1 Binding Pocket

pH-Dependent Specificity of Papain-Like Cysteine Proteases Is Determined by S1 Binding Pocket

Papain-like cysteine proteases (PLCPs) are widely expressed enzymes, the main function of which is low-specific-protein turnover in the acidic conditions of lysosomes. Additionally, these proteases provide specific functions in other compartments such as cytosol, nucleus, and extracellular space. Th...

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Bibliographic Details
Main Authors: Anastasiia Petushkova, Arthur Zalevsky, Neonila Gorokhovets, Vladimir Makarov, Lyudmila Savvateeva, Marina Serebryakova, Andrey Golovin, Evgeni Zernii, Andrey Zamyatnin
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biology and Life Sciences Forum
Subjects:
papain-like cysteine proteases
cysteine cathepsin
enzymatic activity
substrate specificity
binding cleft
Online Access:https://www.mdpi.com/2673-9976/20/1/21

Internet

https://www.mdpi.com/2673-9976/20/1/21

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