pH-Dependent Specificity of Papain-Like Cysteine Proteases Is Determined by S1 Binding Pocket
Papain-like cysteine proteases (PLCPs) are widely expressed enzymes, the main function of which is low-specific-protein turnover in the acidic conditions of lysosomes. Additionally, these proteases provide specific functions in other compartments such as cytosol, nucleus, and extracellular space. Th...
Main Authors: | Anastasiia Petushkova, Arthur Zalevsky, Neonila Gorokhovets, Vladimir Makarov, Lyudmila Savvateeva, Marina Serebryakova, Andrey Golovin, Evgeni Zernii, Andrey Zamyatnin |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-11-01
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Series: | Biology and Life Sciences Forum |
Subjects: | |
Online Access: | https://www.mdpi.com/2673-9976/20/1/21 |
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