Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors.

Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors.

The anthrax toxin is a tripartite toxin, where the two enzymatic subunits require the third subunit, the protective antigen (PA), to interact with cells and be escorted to their cytoplasmic targets. PA binds to cells via one of two receptors, TEM8 and CMG2. Interestingly, the toxin times and trigger...

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Bibliographic Details
Main Authors: Laurence Abrami, Mirko Bischofberger, Béatrice Kunz, Romain Groux, F Gisou van der Goot
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20221438/pdf/?tool=EBI

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