Neutropenic Rat Thigh Infection Model for Evaluation of the Pharmacokinetics/Pharmacodynamics of Anti-Infectives
ABSTRACT The neutropenic mouse infection model is extensively used to characterize the pharmacokinetics/pharmacodynamics (PK/PD) of anti-infective agents. However, it is difficult to evaluate agents following intravenous (i.v.) infusions using this model. Furthermore, in many drug discovery programs...
| Main Authors: | , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
American Society for Microbiology
2023-08-01
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| 丛编: | Microbiology Spectrum |
| 主题: | |
| 在线阅读: | https://journals.asm.org/doi/10.1128/spectrum.00133-23 |