Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients
Background/Aims: Serrated polyposis syndrome (SPS) has been shown to increase the risk of colorectal cancer (CRC). However, little is known about the characteristics of Asian patients with SPS. This study aimed to identify the clinicopathological features and risk of CRC in Korean patients with SPS...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of Intestinal Diseases
2017-07-01
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| Series: | Intestinal Research |
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| Online Access: | https://doi.org/10.5217/ir.2017.15.3.402 |
| _version_ | 1818271198723702784 |
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| author | Eun Ran Kim Jaryong Jeon Jin Hee Lee Yoon Jung Lee Sung Noh Hong Dong Kyung Chang Young-Ho Kim |
| author_facet | Eun Ran Kim Jaryong Jeon Jin Hee Lee Yoon Jung Lee Sung Noh Hong Dong Kyung Chang Young-Ho Kim |
| author_sort | Eun Ran Kim |
| collection | DOAJ |
| description | Background/Aims: Serrated polyposis syndrome (SPS) has been shown to increase the risk of colorectal cancer (CRC). However, little is known about the characteristics of Asian patients with SPS. This study aimed to identify the clinicopathological features and risk of CRC in Korean patients with SPS as well as the differences between Korean and Western patients based on a literature review.Methods: This retrospective study included 30 patients with SPS as defined by World Health Organization classification treated at Samsung Medical Center, Korea, between March 1999 and May 2011.Results: Twenty patients (67%) were male. The median patient age at diagnosis was 56 years (range, 39–76 years). A total of 702 polyps were identified during a median follow-up of 43 months (range, 0–149 months). Serrated polyps were noted more frequently in the distal colon (298/702, 55%). However, large serrated polyps and serrated adenomas were mainly distributed throughout the proximal colon (75% vs. 25% and 81% vs. 19%, respectively); 73.3% had synchronous adenomatous polyps. The incidence of CRC was 10% (3/30 patients), but no interval CRC was detected. A total of 87% of the patients underwent esophagogastroduodenoscopy and 19.2% had significant lesions.Conclusions: The phenotype of SPS in Korean patients is different from that of Western patients. In Korean patients, SPS is more common in men, there were fewer total numbers of serrated adenoma/polyps, and the incidence of CRC was lower than that in Western patients. Korean patients tend to more frequently have abnormal gastric lesions. However, the prevalence of synchronous adenomatous polyps is high in both Western and Korean patients. |
| first_indexed | 2024-12-12T21:22:22Z |
| format | Article |
| id | doaj.art-c0797a4f6cec4b54b4dacf939c133de7 |
| institution | Directory Open Access Journal |
| issn | 1598-9100 |
| language | English |
| last_indexed | 2024-12-12T21:22:22Z |
| publishDate | 2017-07-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj.art-c0797a4f6cec4b54b4dacf939c133de72022-12-22T00:11:32ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002017-07-0115340241010.5217/ir.2017.15.3.402ir.2017.15.3.402Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patientsEun Ran KimJaryong JeonJin Hee Lee0Yoon Jung Lee1Sung Noh Hong2Dong Kyung Chang3Young-Ho Kim4Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Background/Aims: Serrated polyposis syndrome (SPS) has been shown to increase the risk of colorectal cancer (CRC). However, little is known about the characteristics of Asian patients with SPS. This study aimed to identify the clinicopathological features and risk of CRC in Korean patients with SPS as well as the differences between Korean and Western patients based on a literature review.Methods: This retrospective study included 30 patients with SPS as defined by World Health Organization classification treated at Samsung Medical Center, Korea, between March 1999 and May 2011.Results: Twenty patients (67%) were male. The median patient age at diagnosis was 56 years (range, 39–76 years). A total of 702 polyps were identified during a median follow-up of 43 months (range, 0–149 months). Serrated polyps were noted more frequently in the distal colon (298/702, 55%). However, large serrated polyps and serrated adenomas were mainly distributed throughout the proximal colon (75% vs. 25% and 81% vs. 19%, respectively); 73.3% had synchronous adenomatous polyps. The incidence of CRC was 10% (3/30 patients), but no interval CRC was detected. A total of 87% of the patients underwent esophagogastroduodenoscopy and 19.2% had significant lesions.Conclusions: The phenotype of SPS in Korean patients is different from that of Western patients. In Korean patients, SPS is more common in men, there were fewer total numbers of serrated adenoma/polyps, and the incidence of CRC was lower than that in Western patients. Korean patients tend to more frequently have abnormal gastric lesions. However, the prevalence of synchronous adenomatous polyps is high in both Western and Korean patients.https://doi.org/10.5217/ir.2017.15.3.402Serrated polyposis syndromeSerrated adenoma/polypColorectal neoplasms |
| spellingShingle | Eun Ran Kim Jaryong Jeon Jin Hee Lee Yoon Jung Lee Sung Noh Hong Dong Kyung Chang Young-Ho Kim Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients Intestinal Research Serrated polyposis syndrome Serrated adenoma/polyp Colorectal neoplasms |
| title | Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients |
| title_full | Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients |
| title_fullStr | Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients |
| title_full_unstemmed | Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients |
| title_short | Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients |
| title_sort | clinical characteristics of patients with serrated polyposis syndrome in korea comparison with western patients |
| topic | Serrated polyposis syndrome Serrated adenoma/polyp Colorectal neoplasms |
| url | https://doi.org/10.5217/ir.2017.15.3.402 |
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