Characterization of 7-Methylguanosine Identified Biochemical Recurrence and Tumor Immune Microenvironment in Prostate Cancer
Prostate cancer (PCa) has a high incidence rate, mortality rate, and biochemical recurrence (BCR) rate. 7-Methylguanosine (m7G), as one of the RNA modifications, has been considered to be actively involved in cancer-related translation disorders in recent years. Therefore, we first used The Cancer G...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.900203/full |
| _version_ | 1818467016313405440 |
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| author | Sheng Xin Sheng Xin Yuxuan Deng Yuxuan Deng Jiaquan Mao Jiaquan Mao Tao Wang Tao Wang Jihong Liu Jihong Liu Shaogang Wang Shaogang Wang Xiaodong Song Xiaodong Song Wen Song Wen Song Xiaming Liu Xiaming Liu |
| author_facet | Sheng Xin Sheng Xin Yuxuan Deng Yuxuan Deng Jiaquan Mao Jiaquan Mao Tao Wang Tao Wang Jihong Liu Jihong Liu Shaogang Wang Shaogang Wang Xiaodong Song Xiaodong Song Wen Song Wen Song Xiaming Liu Xiaming Liu |
| author_sort | Sheng Xin |
| collection | DOAJ |
| description | Prostate cancer (PCa) has a high incidence rate, mortality rate, and biochemical recurrence (BCR) rate. 7-Methylguanosine (m7G), as one of the RNA modifications, has been considered to be actively involved in cancer-related translation disorders in recent years. Therefore, we first used The Cancer Genome Atlas (TCGA) database to identify prognosis and m7G-related long non-coding RNAs (lncRNAs). Then we randomly divided the samples into the training set and test set and then constructed and verified the m7G lnRNA prognostic model (m7Gscore) by the least absolute shrinkage and selection operator (LASSO) regression analysis. The m7Gscore has been proved to be an independent marker of BCR-free survival in patients with PCa. Furthermore, the m7Gscore was significantly correlated with the tumor immune microenvironment (TIME) and somatic mutation of PCa patients and had the potential to be an indicator for the selection of drug treatment. We also clustered TCGA cohort into three m7G-related patterns (C1, C2, and C3). The Kaplan–Meier survival analysis revealed that C1 had the best BCR-free survival and C3 had the worst. The TIME was also significantly distinct among the three m7G-related patterns. According to the TIME characteristics of the patterns, we defined C1, C2, and C3 as immune-desert phenotype, immune-inflamed phenotype, and immune-excluded phenotype, respectively. |
| first_indexed | 2024-04-13T21:04:04Z |
| format | Article |
| id | doaj.art-c0798515834f480e9730fbde22f151d9 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T21:04:04Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c0798515834f480e9730fbde22f151d92022-12-22T02:30:03ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-05-011210.3389/fonc.2022.900203900203Characterization of 7-Methylguanosine Identified Biochemical Recurrence and Tumor Immune Microenvironment in Prostate CancerSheng Xin0Sheng Xin1Yuxuan Deng2Yuxuan Deng3Jiaquan Mao4Jiaquan Mao5Tao Wang6Tao Wang7Jihong Liu8Jihong Liu9Shaogang Wang10Shaogang Wang11Xiaodong Song12Xiaodong Song13Wen Song14Wen Song15Xiaming Liu16Xiaming Liu17Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaProstate cancer (PCa) has a high incidence rate, mortality rate, and biochemical recurrence (BCR) rate. 7-Methylguanosine (m7G), as one of the RNA modifications, has been considered to be actively involved in cancer-related translation disorders in recent years. Therefore, we first used The Cancer Genome Atlas (TCGA) database to identify prognosis and m7G-related long non-coding RNAs (lncRNAs). Then we randomly divided the samples into the training set and test set and then constructed and verified the m7G lnRNA prognostic model (m7Gscore) by the least absolute shrinkage and selection operator (LASSO) regression analysis. The m7Gscore has been proved to be an independent marker of BCR-free survival in patients with PCa. Furthermore, the m7Gscore was significantly correlated with the tumor immune microenvironment (TIME) and somatic mutation of PCa patients and had the potential to be an indicator for the selection of drug treatment. We also clustered TCGA cohort into three m7G-related patterns (C1, C2, and C3). The Kaplan–Meier survival analysis revealed that C1 had the best BCR-free survival and C3 had the worst. The TIME was also significantly distinct among the three m7G-related patterns. According to the TIME characteristics of the patterns, we defined C1, C2, and C3 as immune-desert phenotype, immune-inflamed phenotype, and immune-excluded phenotype, respectively.https://www.frontiersin.org/articles/10.3389/fonc.2022.900203/fullprostate cancer7-methylguanosinelncRNAsbiochemical recurrencetumor immune microenvironmentprognostic model |
| spellingShingle | Sheng Xin Sheng Xin Yuxuan Deng Yuxuan Deng Jiaquan Mao Jiaquan Mao Tao Wang Tao Wang Jihong Liu Jihong Liu Shaogang Wang Shaogang Wang Xiaodong Song Xiaodong Song Wen Song Wen Song Xiaming Liu Xiaming Liu Characterization of 7-Methylguanosine Identified Biochemical Recurrence and Tumor Immune Microenvironment in Prostate Cancer Frontiers in Oncology prostate cancer 7-methylguanosine lncRNAs biochemical recurrence tumor immune microenvironment prognostic model |
| title | Characterization of 7-Methylguanosine Identified Biochemical Recurrence and Tumor Immune Microenvironment in Prostate Cancer |
| title_full | Characterization of 7-Methylguanosine Identified Biochemical Recurrence and Tumor Immune Microenvironment in Prostate Cancer |
| title_fullStr | Characterization of 7-Methylguanosine Identified Biochemical Recurrence and Tumor Immune Microenvironment in Prostate Cancer |
| title_full_unstemmed | Characterization of 7-Methylguanosine Identified Biochemical Recurrence and Tumor Immune Microenvironment in Prostate Cancer |
| title_short | Characterization of 7-Methylguanosine Identified Biochemical Recurrence and Tumor Immune Microenvironment in Prostate Cancer |
| title_sort | characterization of 7 methylguanosine identified biochemical recurrence and tumor immune microenvironment in prostate cancer |
| topic | prostate cancer 7-methylguanosine lncRNAs biochemical recurrence tumor immune microenvironment prognostic model |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.900203/full |
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