Pleiotrophin and metabolic disorders: insights into its role in metabolism
Pleiotrophin (PTN) is a cytokine which has been for long studied at the level of the central nervous system, however few studies focus on its role in the peripheral organs. The main aim of this review is to summarize the state of the art of what is known up to date about pleiotrophin and its implica...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1225150/full |
| _version_ | 1797785263384035328 |
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| author | Cristina Ballesteros-Pla María Gracia Sánchez-Alonso Javier Pizarro-Delgado Agata Zuccaro Julio Sevillano María Pilar Ramos-Álvarez |
| author_facet | Cristina Ballesteros-Pla María Gracia Sánchez-Alonso Javier Pizarro-Delgado Agata Zuccaro Julio Sevillano María Pilar Ramos-Álvarez |
| author_sort | Cristina Ballesteros-Pla |
| collection | DOAJ |
| description | Pleiotrophin (PTN) is a cytokine which has been for long studied at the level of the central nervous system, however few studies focus on its role in the peripheral organs. The main aim of this review is to summarize the state of the art of what is known up to date about pleiotrophin and its implications in the main metabolic organs. In summary, pleiotrophin promotes the proliferation of preadipocytes, pancreatic β cells, as well as cells during the mammary gland development. Moreover, this cytokine is important for the structural integrity of the liver and the neuromuscular junction in the skeletal muscle. From a metabolic point of view, pleiotrophin plays a key role in the maintenance of glucose and lipid as well as whole-body insulin homeostasis and favors oxidative metabolism in the skeletal muscle. All in all, this review proposes pleiotrophin as a druggable target to prevent from the development of insulin-resistance-related pathologies. |
| first_indexed | 2024-03-13T00:52:32Z |
| format | Article |
| id | doaj.art-c07a4dbebf1d4951b1501737a4cf2dfc |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T00:52:32Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-c07a4dbebf1d4951b1501737a4cf2dfc2023-07-07T12:27:18ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-07-011410.3389/fendo.2023.12251501225150Pleiotrophin and metabolic disorders: insights into its role in metabolismCristina Ballesteros-PlaMaría Gracia Sánchez-AlonsoJavier Pizarro-DelgadoAgata ZuccaroJulio SevillanoMaría Pilar Ramos-ÁlvarezPleiotrophin (PTN) is a cytokine which has been for long studied at the level of the central nervous system, however few studies focus on its role in the peripheral organs. The main aim of this review is to summarize the state of the art of what is known up to date about pleiotrophin and its implications in the main metabolic organs. In summary, pleiotrophin promotes the proliferation of preadipocytes, pancreatic β cells, as well as cells during the mammary gland development. Moreover, this cytokine is important for the structural integrity of the liver and the neuromuscular junction in the skeletal muscle. From a metabolic point of view, pleiotrophin plays a key role in the maintenance of glucose and lipid as well as whole-body insulin homeostasis and favors oxidative metabolism in the skeletal muscle. All in all, this review proposes pleiotrophin as a druggable target to prevent from the development of insulin-resistance-related pathologies.https://www.frontiersin.org/articles/10.3389/fendo.2023.1225150/fullpleiotrophinreceptor protein tyrosine phosphatase β/ζ (RPTP β/ζ)metabolismmetabolic disordersperipheral organs |
| spellingShingle | Cristina Ballesteros-Pla María Gracia Sánchez-Alonso Javier Pizarro-Delgado Agata Zuccaro Julio Sevillano María Pilar Ramos-Álvarez Pleiotrophin and metabolic disorders: insights into its role in metabolism Frontiers in Endocrinology pleiotrophin receptor protein tyrosine phosphatase β/ζ (RPTP β/ζ) metabolism metabolic disorders peripheral organs |
| title | Pleiotrophin and metabolic disorders: insights into its role in metabolism |
| title_full | Pleiotrophin and metabolic disorders: insights into its role in metabolism |
| title_fullStr | Pleiotrophin and metabolic disorders: insights into its role in metabolism |
| title_full_unstemmed | Pleiotrophin and metabolic disorders: insights into its role in metabolism |
| title_short | Pleiotrophin and metabolic disorders: insights into its role in metabolism |
| title_sort | pleiotrophin and metabolic disorders insights into its role in metabolism |
| topic | pleiotrophin receptor protein tyrosine phosphatase β/ζ (RPTP β/ζ) metabolism metabolic disorders peripheral organs |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1225150/full |
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