The prognostic significance of LTBP2 for malignant tumors
Abstract. Background & aims:. At present, increasing reports have shown that latent transforming growth factor-β-binding protein 2 (LTBP2) was associated with the prognosis of many types of cancer. We performed rounded analysis to comprehensively analyze and evaluate the prognostic significance...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2022-04-01
|
| Series: | Medicine |
| Online Access: | http://journals.lww.com/10.1097/MD.0000000000029207 |
| _version_ | 1818205943087759360 |
|---|---|
| author | Jianmeng Zhao, MD Xiaokang Liu, MD Ke Cong, MD Jinzhe Chang, MD Hongqing Shan, MD Yuenan Zheng, MD Mihai Dorin Vartolomei. |
| author_facet | Jianmeng Zhao, MD Xiaokang Liu, MD Ke Cong, MD Jinzhe Chang, MD Hongqing Shan, MD Yuenan Zheng, MD Mihai Dorin Vartolomei. |
| author_sort | Jianmeng Zhao, MD |
| collection | DOAJ |
| description | Abstract. Background & aims:. At present, increasing reports have shown that latent transforming growth factor-β-binding protein 2 (LTBP2) was associated with the prognosis of many types of cancer. We performed rounded analysis to comprehensively analyze and evaluate the prognostic significance of LTBP2 for patients with malignant tumors.
Methods:. We identified relevant studies by searching database including PubMed, Embase, Cochrane Library, and Web of Science. The odds ratio with its 95% confidence interval (CI) was used to assess the correlation between LTBP2 and clinicopathologic features or overall survival of patients with cancer. Hazard ratio with its 95% CI was used to explore the prognostic risk factors. The analysis was performed and assessed using Review Manager 5.2.
Results:. A total of 11 studies including 2322 participants were included in this systematic review. Pooled results showed that malignant tissues experienced higher incidence of high LTBP2 expression when compared with adjacent or normal tissues. Patients with high LTBP2 expression experienced significantly lower 1-year, 2-year, 3-year, and 4-year overall survival rate, with the pooled odds ratios being 0.26 (95% CI 0.13–0.53; P = .0002), 0.27 (95% CI 0.14–0.50; P < .0001), 0.26 (95% CI 0.13–0.53; P = .0002), and 0.21 (95% CI 0.06–0.73; P = .01) respectively. Univariate analysis showed high LTBP2 expression, tumor node metastasis stage, T stage, and N stage were prognostic factors of patients with tumors. Multivariate analysis indicated high LTBP2 expression was an independent prognostic factor.
Conclusions:. The present analysis suggested that LTBP2 may have significant association with survival of patients with cancer. High LTBP2 expression was an independent prognostic factor and indicated poor survival. |
| first_indexed | 2024-12-12T04:05:09Z |
| format | Article |
| id | doaj.art-c07cd19072824a8aaae887c9acc8704d |
| institution | Directory Open Access Journal |
| issn | 0025-7974 1536-5964 |
| language | English |
| last_indexed | 2024-12-12T04:05:09Z |
| publishDate | 2022-04-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Medicine |
| spelling | doaj.art-c07cd19072824a8aaae887c9acc8704d2022-12-22T00:38:48ZengWolters KluwerMedicine0025-79741536-59642022-04-0110117e2920710.1097/MD.0000000000029207202204290-00008The prognostic significance of LTBP2 for malignant tumorsJianmeng Zhao, MDXiaokang Liu, MDKe Cong, MDJinzhe Chang, MDHongqing Shan, MDYuenan Zheng, MDMihai Dorin Vartolomei.Abstract. Background & aims:. At present, increasing reports have shown that latent transforming growth factor-β-binding protein 2 (LTBP2) was associated with the prognosis of many types of cancer. We performed rounded analysis to comprehensively analyze and evaluate the prognostic significance of LTBP2 for patients with malignant tumors. Methods:. We identified relevant studies by searching database including PubMed, Embase, Cochrane Library, and Web of Science. The odds ratio with its 95% confidence interval (CI) was used to assess the correlation between LTBP2 and clinicopathologic features or overall survival of patients with cancer. Hazard ratio with its 95% CI was used to explore the prognostic risk factors. The analysis was performed and assessed using Review Manager 5.2. Results:. A total of 11 studies including 2322 participants were included in this systematic review. Pooled results showed that malignant tissues experienced higher incidence of high LTBP2 expression when compared with adjacent or normal tissues. Patients with high LTBP2 expression experienced significantly lower 1-year, 2-year, 3-year, and 4-year overall survival rate, with the pooled odds ratios being 0.26 (95% CI 0.13–0.53; P = .0002), 0.27 (95% CI 0.14–0.50; P < .0001), 0.26 (95% CI 0.13–0.53; P = .0002), and 0.21 (95% CI 0.06–0.73; P = .01) respectively. Univariate analysis showed high LTBP2 expression, tumor node metastasis stage, T stage, and N stage were prognostic factors of patients with tumors. Multivariate analysis indicated high LTBP2 expression was an independent prognostic factor. Conclusions:. The present analysis suggested that LTBP2 may have significant association with survival of patients with cancer. High LTBP2 expression was an independent prognostic factor and indicated poor survival.http://journals.lww.com/10.1097/MD.0000000000029207 |
| spellingShingle | Jianmeng Zhao, MD Xiaokang Liu, MD Ke Cong, MD Jinzhe Chang, MD Hongqing Shan, MD Yuenan Zheng, MD Mihai Dorin Vartolomei. The prognostic significance of LTBP2 for malignant tumors Medicine |
| title | The prognostic significance of LTBP2 for malignant tumors |
| title_full | The prognostic significance of LTBP2 for malignant tumors |
| title_fullStr | The prognostic significance of LTBP2 for malignant tumors |
| title_full_unstemmed | The prognostic significance of LTBP2 for malignant tumors |
| title_short | The prognostic significance of LTBP2 for malignant tumors |
| title_sort | prognostic significance of ltbp2 for malignant tumors |
| url | http://journals.lww.com/10.1097/MD.0000000000029207 |
| work_keys_str_mv | AT jianmengzhaomd theprognosticsignificanceofltbp2formalignanttumors AT xiaokangliumd theprognosticsignificanceofltbp2formalignanttumors AT kecongmd theprognosticsignificanceofltbp2formalignanttumors AT jinzhechangmd theprognosticsignificanceofltbp2formalignanttumors AT hongqingshanmd theprognosticsignificanceofltbp2formalignanttumors AT yuenanzhengmd theprognosticsignificanceofltbp2formalignanttumors AT mihaidorinvartolomei theprognosticsignificanceofltbp2formalignanttumors AT jianmengzhaomd prognosticsignificanceofltbp2formalignanttumors AT xiaokangliumd prognosticsignificanceofltbp2formalignanttumors AT kecongmd prognosticsignificanceofltbp2formalignanttumors AT jinzhechangmd prognosticsignificanceofltbp2formalignanttumors AT hongqingshanmd prognosticsignificanceofltbp2formalignanttumors AT yuenanzhengmd prognosticsignificanceofltbp2formalignanttumors AT mihaidorinvartolomei prognosticsignificanceofltbp2formalignanttumors |