Effects of Two Types of Restraint Stress on the Spontaneous Behaviour in Rats
Our previous findings suggested the existence of stressor-specific behavioural and cognitive responses in rats. In the present study, restraint stressor (immobilization, IMO) and restraint stressor combined with partial immersion of rats into water (IMO+C) were applied for 1 hour to Wistar male rats...
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| Format: | Article |
| Language: | English |
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Karolinum Press
2004-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/47/3/0177/ |
| _version_ | 1818259793268178944 |
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| author | Lenka Trnečková Pavel Šída Sixtus Hynie Ivan Krejčí Zdeněk Hliňák Věra Klenerová |
| author_facet | Lenka Trnečková Pavel Šída Sixtus Hynie Ivan Krejčí Zdeněk Hliňák Věra Klenerová |
| author_sort | Lenka Trnečková |
| collection | DOAJ |
| description | Our previous findings suggested the existence of stressor-specific behavioural and cognitive responses in rats. In the present study, restraint stressor (immobilization, IMO) and restraint stressor combined with partial immersion of rats into water (IMO+C) were applied for 1 hour to Wistar male rats and their spontaneous behaviour was examined in the open field test. The classic behavioural parameters were recorded: crossing, rearing, and resting. When tested 1 and 4 hours after IMO+C, animals exhibited strong suppression of locomotor and exploratory activity (crossing and rearing); partial inhibition of both behavioural variables was found after IMO. Thus, substantial differences were observed in dependence on the length of period between the end of stressor application and the start of testing. In testing performed one week later, the locomotor and exploratory activity levels of both IMO and IMO+C animals corresponded to the control ones. These data suggest a differential behavioural response to both used stressors that may result from their different proportion of psychical and physical components. In conclusion, our results provide other data for the support of differential effects of two types of restraint stressors on spontaneous behaviour of animals exposed to a novel environment. |
| first_indexed | 2024-12-12T18:21:05Z |
| format | Article |
| id | doaj.art-c08057f1421348e38b681e1cc8e73648 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-12T18:21:05Z |
| publishDate | 2004-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-c08057f1421348e38b681e1cc8e736482022-12-22T00:16:09ZengKarolinum PressActa Medica1211-42861805-96942004-01-0147317718010.14712/18059694.2018.87Effects of Two Types of Restraint Stress on the Spontaneous Behaviour in RatsLenka Trnečková0Pavel Šída1Sixtus Hynie2Ivan Krejčí3Zdeněk Hliňák4Věra Klenerová5Charles University in Prague, First Faculty of Medicine, Department of Pharmacology, Prague, Czech RepublicCharles University in Prague, First Faculty of Medicine, Department of Pharmacology, Prague, Czech RepublicCharles University in Prague, First Faculty of Medicine, Department of Pharmacology, Prague, Czech RepublicCharles University in Prague, First Faculty of Medicine, Department of Pharmacology, Prague, Czech RepublicCharles University in Prague, First Faculty of Medicine, Department of Pharmacology, Prague, Czech RepublicCharles University in Prague, First Faculty of Medicine, Department of Pharmacology, Prague, Czech RepublicOur previous findings suggested the existence of stressor-specific behavioural and cognitive responses in rats. In the present study, restraint stressor (immobilization, IMO) and restraint stressor combined with partial immersion of rats into water (IMO+C) were applied for 1 hour to Wistar male rats and their spontaneous behaviour was examined in the open field test. The classic behavioural parameters were recorded: crossing, rearing, and resting. When tested 1 and 4 hours after IMO+C, animals exhibited strong suppression of locomotor and exploratory activity (crossing and rearing); partial inhibition of both behavioural variables was found after IMO. Thus, substantial differences were observed in dependence on the length of period between the end of stressor application and the start of testing. In testing performed one week later, the locomotor and exploratory activity levels of both IMO and IMO+C animals corresponded to the control ones. These data suggest a differential behavioural response to both used stressors that may result from their different proportion of psychical and physical components. In conclusion, our results provide other data for the support of differential effects of two types of restraint stressors on spontaneous behaviour of animals exposed to a novel environment.https://actamedica.lfhk.cuni.cz/47/3/0177/Open field testRestraint stressorRestraint/cold stressorSpontaneous behaviourRatStress |
| spellingShingle | Lenka Trnečková Pavel Šída Sixtus Hynie Ivan Krejčí Zdeněk Hliňák Věra Klenerová Effects of Two Types of Restraint Stress on the Spontaneous Behaviour in Rats Acta Medica Open field test Restraint stressor Restraint/cold stressor Spontaneous behaviour Rat Stress |
| title | Effects of Two Types of Restraint Stress on the Spontaneous Behaviour in Rats |
| title_full | Effects of Two Types of Restraint Stress on the Spontaneous Behaviour in Rats |
| title_fullStr | Effects of Two Types of Restraint Stress on the Spontaneous Behaviour in Rats |
| title_full_unstemmed | Effects of Two Types of Restraint Stress on the Spontaneous Behaviour in Rats |
| title_short | Effects of Two Types of Restraint Stress on the Spontaneous Behaviour in Rats |
| title_sort | effects of two types of restraint stress on the spontaneous behaviour in rats |
| topic | Open field test Restraint stressor Restraint/cold stressor Spontaneous behaviour Rat Stress |
| url | https://actamedica.lfhk.cuni.cz/47/3/0177/ |
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