Pasteurized <i>Akkermansia muciniphila</i> Reduces Fat Accumulation via <i>nhr-49</i>-Mediated Nuclear Hormone Signaling Pathway in <i>Caenorhabditis elegans</i>
Pasteurized <i>Akkermansia muciniphila</i> (p-AKK) is related to lipid metabolism and helps control obesity. The main goal of this study was to investigate the role and mechanism of p-AKK in lipid metabolism using <i>Caenorhabditis elegans</i>. The results showed that p-AKK i...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/19/6159 |
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| author | Zhongqin Wu Yu Xiao Fang Zhou Jiaxu Chen Xinming Chen Aixiang Hou Yuanliang Wang Zongjun Li |
| author_facet | Zhongqin Wu Yu Xiao Fang Zhou Jiaxu Chen Xinming Chen Aixiang Hou Yuanliang Wang Zongjun Li |
| author_sort | Zhongqin Wu |
| collection | DOAJ |
| description | Pasteurized <i>Akkermansia muciniphila</i> (p-AKK) is related to lipid metabolism and helps control obesity. The main goal of this study was to investigate the role and mechanism of p-AKK in lipid metabolism using <i>Caenorhabditis elegans</i>. The results showed that p-AKK increased the healthy lifespan of nematodes and helped maintain exercise ability in aging, suggesting a potential increase in energy expenditure. The overall fat deposition and triglyceride level were significantly decreased and the p-AKK anti-oxidative stress helped to regulate fatty acid composition. Additionally, the transcriptome results showed that p-AKK increased the expression of lipo-hydrolase and fatty acid β-oxidation-related genes, including <i>lipl-4</i>, <i>nhr-49</i>, <i>acs-2</i> and <i>acdh-8</i>, while it decreased the expression of fat synthesis-related genes, including <i>fat-7</i>, <i>elo-2</i> and <i>men-1</i>. These results partially explain the mechanisms underlying the fact that p-AKK decreases fat accumulation of <i>C. elegans</i> via <i>nhr-49</i>/<i>acs-2</i>-mediated signaling involved in fatty acid β-oxidation and synthesis. |
| first_indexed | 2024-03-09T21:26:56Z |
| format | Article |
| id | doaj.art-c08085400d774b88bb0486745b13c4d7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:26:56Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c08085400d774b88bb0486745b13c4d72023-11-23T21:06:38ZengMDPI AGMolecules1420-30492022-09-012719615910.3390/molecules27196159Pasteurized <i>Akkermansia muciniphila</i> Reduces Fat Accumulation via <i>nhr-49</i>-Mediated Nuclear Hormone Signaling Pathway in <i>Caenorhabditis elegans</i>Zhongqin Wu0Yu Xiao1Fang Zhou2Jiaxu Chen3Xinming Chen4Aixiang Hou5Yuanliang Wang6Zongjun Li7College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaLongping Branch Graduate School, Hunan University, Changsha 526061, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaPasteurized <i>Akkermansia muciniphila</i> (p-AKK) is related to lipid metabolism and helps control obesity. The main goal of this study was to investigate the role and mechanism of p-AKK in lipid metabolism using <i>Caenorhabditis elegans</i>. The results showed that p-AKK increased the healthy lifespan of nematodes and helped maintain exercise ability in aging, suggesting a potential increase in energy expenditure. The overall fat deposition and triglyceride level were significantly decreased and the p-AKK anti-oxidative stress helped to regulate fatty acid composition. Additionally, the transcriptome results showed that p-AKK increased the expression of lipo-hydrolase and fatty acid β-oxidation-related genes, including <i>lipl-4</i>, <i>nhr-49</i>, <i>acs-2</i> and <i>acdh-8</i>, while it decreased the expression of fat synthesis-related genes, including <i>fat-7</i>, <i>elo-2</i> and <i>men-1</i>. These results partially explain the mechanisms underlying the fact that p-AKK decreases fat accumulation of <i>C. elegans</i> via <i>nhr-49</i>/<i>acs-2</i>-mediated signaling involved in fatty acid β-oxidation and synthesis.https://www.mdpi.com/1420-3049/27/19/6159<i>Akkermansia muciniphila</i>lipid metabolism<i>Caenorhabditis elegans</i>fatty acid β-oxidationfatty acid synthesis<i>nhr-49</i> signaling pathway |
| spellingShingle | Zhongqin Wu Yu Xiao Fang Zhou Jiaxu Chen Xinming Chen Aixiang Hou Yuanliang Wang Zongjun Li Pasteurized <i>Akkermansia muciniphila</i> Reduces Fat Accumulation via <i>nhr-49</i>-Mediated Nuclear Hormone Signaling Pathway in <i>Caenorhabditis elegans</i> Molecules <i>Akkermansia muciniphila</i> lipid metabolism <i>Caenorhabditis elegans</i> fatty acid β-oxidation fatty acid synthesis <i>nhr-49</i> signaling pathway |
| title | Pasteurized <i>Akkermansia muciniphila</i> Reduces Fat Accumulation via <i>nhr-49</i>-Mediated Nuclear Hormone Signaling Pathway in <i>Caenorhabditis elegans</i> |
| title_full | Pasteurized <i>Akkermansia muciniphila</i> Reduces Fat Accumulation via <i>nhr-49</i>-Mediated Nuclear Hormone Signaling Pathway in <i>Caenorhabditis elegans</i> |
| title_fullStr | Pasteurized <i>Akkermansia muciniphila</i> Reduces Fat Accumulation via <i>nhr-49</i>-Mediated Nuclear Hormone Signaling Pathway in <i>Caenorhabditis elegans</i> |
| title_full_unstemmed | Pasteurized <i>Akkermansia muciniphila</i> Reduces Fat Accumulation via <i>nhr-49</i>-Mediated Nuclear Hormone Signaling Pathway in <i>Caenorhabditis elegans</i> |
| title_short | Pasteurized <i>Akkermansia muciniphila</i> Reduces Fat Accumulation via <i>nhr-49</i>-Mediated Nuclear Hormone Signaling Pathway in <i>Caenorhabditis elegans</i> |
| title_sort | pasteurized i akkermansia muciniphila i reduces fat accumulation via i nhr 49 i mediated nuclear hormone signaling pathway in i caenorhabditis elegans i |
| topic | <i>Akkermansia muciniphila</i> lipid metabolism <i>Caenorhabditis elegans</i> fatty acid β-oxidation fatty acid synthesis <i>nhr-49</i> signaling pathway |
| url | https://www.mdpi.com/1420-3049/27/19/6159 |
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