Pasteurized <i>Akkermansia muciniphila</i> Reduces Fat Accumulation via <i>nhr-49</i>-Mediated Nuclear Hormone Signaling Pathway in <i>Caenorhabditis elegans</i>

Pasteurized <i>Akkermansia muciniphila</i> Reduces Fat Accumulation via <i>nhr-49</i>-Mediated Nuclear Hormone Signaling Pathway in <i>Caenorhabditis elegans</i>

Pasteurized <i>Akkermansia muciniphila</i> (p-AKK) is related to lipid metabolism and helps control obesity. The main goal of this study was to investigate the role and mechanism of p-AKK in lipid metabolism using <i>Caenorhabditis elegans</i>. The results showed that p-AKK i...

Full description

Bibliographic Details
Main Authors:	Zhongqin Wu, Yu Xiao, Fang Zhou, Jiaxu Chen, Xinming Chen, Aixiang Hou, Yuanliang Wang, Zongjun Li
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Series:	Molecules
Subjects:	<i>Akkermansia muciniphila</i> lipid metabolism <i>Caenorhabditis elegans</i> fatty acid β-oxidation fatty acid synthesis <i>nhr-49</i> signaling pathway
Online Access:	https://www.mdpi.com/1420-3049/27/19/6159

Similar Items

Dissecting the Neuronal Contributions of the Lipid Regulator NHR-49 Function in Lifespan and Behavior in <i>C. elegans</i>
by: Saebom Kwon, et al.
Published: (2023-12-01)

<i>Akkermansia muciniphila</i> Cell-Free Supernatant Improves Glucose and Lipid Metabolisms in <i>Caenorhabditis elegans</i>
by: Zhong-Qin Wu, et al.
Published: (2023-03-01)

Characterization and Preliminary Safety Evaluation of <i>Akkermansia muciniphila</i> PROBIO
by: Xin Ma, et al.
Published: (2024-01-01)

A Critical Perspective on the Supplementation of <i>Akkermansia muciniphila</i>: Benefits and Harms
by: Vito Chiantera, et al.
Published: (2023-05-01)

Comparative Genomics and Physiology of <i>Akkermansia muciniphila</i> Isolates from Human Intestine Reveal Specialized Mucosal Adaptation
by: Janneke P. Ouwerkerk, et al.
Published: (2022-08-01)

Oral Prevalence of <i>Akkermansia muciniphila</i> Differs among Pediatric and Adult Orthodontic and Non-Orthodontic Patients
by: Ching Shen, et al.
Published: (2023-01-01)

<i>Akkermansia muciniphila</i> Alleviates Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Mice
by: Yali Xu, et al.
Published: (2023-01-01)

<i>Akkermansia muciniphila</i> and <i>Faecalibacterium prausnitzii</i> in Immune-Related Diseases
by: Raden Mohamad Rendy Ariezal Effendi, et al.
Published: (2022-11-01)

<i>Akkermansia muciniphila</i> Ameliorates Alcoholic Liver Disease in Experimental Mice by Regulating Serum Metabolism and Improving Gut Dysbiosis
by: Cheng Fang, et al.
Published: (2023-10-01)

<i>Akkermansia muciniphila</i> Suppresses High-Fat Diet-Induced Obesity and Related Metabolic Disorders in Beagles
by: Xiao-Qi Lin, et al.
Published: (2022-09-01)

Analysis of <i>Akkermansia muciniphila</i> in Mulberry Galacto-Oligosaccharide Medium via Comparative Transcriptomics
by: Erna Li, et al.
Published: (2023-01-01)

<i>Akkermansia muciniphila</i> Is Beneficial to a Mouse Model of Parkinson’s Disease, via Alleviated Neuroinflammation and Promoted Neurogenesis, with Involvement of SCFAs
by: Chen-Meng Qiao, et al.
Published: (2024-02-01)

Effect of Extracelluar Vesicles Derived from <i>Akkermansia muciniphila</i> on Intestinal Barrier in Colitis Mice
by: Ting Zheng, et al.
Published: (2023-11-01)

Rhubarb Supplementation Prevents Diet-Induced Obesity and Diabetes in Association with Increased <i>Akkermansia muciniphila</i> in Mice
by: Marion Régnier, et al.
Published: (2020-09-01)

The Synbiotic Combination of <i>Akkermansia muciniphila</i> and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation
by: María Juárez-Fernández, et al.
Published: (2021-12-01)

Food Reward Alterations during Obesity Are Associated with Inflammation in the Striatum in Mice: Beneficial Effects of <i>Akkermansia muciniphila</i>
by: Sabrina J. P. Huwart, et al.
Published: (2022-08-01)

Beneficial Effects of Newly Isolated <i>Akkermansia muciniphila</i> Strains from the Human Gut on Obesity and Metabolic Dysregulation
by: Meng Yang, et al.
Published: (2020-09-01)

<i>Eurotium cristatum</i> from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic <i>Akkermansia muciniphila</i> in High-Fat-Fed Obese Mice
by: Yu Wang, et al.
Published: (2023-10-01)

<i>Periplaneta </i><i>americana</i> Extract Pretreatment Alleviates Oxidative Stress and Inflammation and Increases the Abundance of Gut <i>Akkermansia muciniphila</i> in Diquat-Induced Mice
by: Shiyi Lu, et al.
Published: (2022-09-01)

Beneficial Effects of <i>Akkermansia muciniphila</i> Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists
by: Clara Depommier, et al.
Published: (2021-01-01)

Preliminary Evaluation of the Safety and Probiotic Potential of <i>Akkermansia muciniphila</i> DSM 22959 in Comparison with <i>Lactobacillus rhamnosus</i> GG
by: Autilia Cozzolino, et al.
Published: (2020-01-01)

<i>Akkermansia muciniphila</i> is Negatively Correlated with Hemoglobin A1c in Refractory Diabetes
by: Ching-Tang Shih, et al.
Published: (2020-09-01)

Polyphenols as Drivers of a Homeostatic Gut Microecology and Immuno-Metabolic Traits of <i>Akkermansia muciniphila</i>: From Mouse to Man
by: María Carolina Rodríguez-Daza, et al.
Published: (2022-12-01)

<i>Akkermansia muciniphila</i> Reduces Peritonitis and Improves Intestinal Tissue Wound Healing after a Colonic Transmural Defect by a MyD88-Dependent Mechanism
by: Radu Bachmann, et al.
Published: (2022-08-01)

<i>Akkermansia muciniphila</i> Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal Mucosal Barrier Disruption
by: Jiayu Yu, et al.
Published: (2022-07-01)

<i>Akkermansia muciniphila</i> Encapsulated in Calcium-Alginate Hydrogelated Matrix: Viability and Stability over Aerobic Storage and Simulated Gastrointestinal Conditions
by: Daniela Machado, et al.
Published: (2023-11-01)

The Feasibility of Integrating Spray-Dried and Freeze-Dried Oat β-Glucans into a Synbiotic Formulation with <i>Akkermansia muciniphila</i>
by: Vanda Sargautiene, et al.
Published: (2023-10-01)

Functional Plasmon-Activated Water Increases <i>Akkermansia muciniphila</i> Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease
by: Chun-Chao Chang, et al.
Published: (2022-09-01)

<i>Akkermansia muciniphila</i> as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes?
by: Huafeng Jian, et al.
Published: (2023-02-01)

Role of <i>Akkermansia</i> in Human Diseases: From Causation to Therapeutic Properties
by: Antonio Pellegrino, et al.
Published: (2023-04-01)

Pasteurized <i>Akkermansia muciniphila</i> Ameliorate the LPS-Induced Intestinal Barrier Dysfunction via Modulating AMPK and NF-κB through TLR2 in Caco-2 Cells
by: Mengxuan Shi, et al.
Published: (2022-02-01)

Heat-Inactivated <i>Akkermansia muciniphila</i> Improves Gut Permeability but Does Not Prevent Development of Non-Alcoholic Steatohepatitis in Diet-Induced Obese Ldlr−/−.Leiden Mice
by: Martine C. Morrison, et al.
Published: (2022-02-01)

Recognizing the Benefits of Pre-/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence of <i>Akkermansia muciniphila</i> as a Key Gut Bacterium
by: Raluca Anca Corb Aron, et al.
Published: (2021-03-01)

A Combined Supplement of Probiotic Strains AP-32, bv-77, and CP-9 Increased <i>Akkermansia mucinphila</i> and Reduced Non-Esterified Fatty Acids and Energy Metabolism in HFD-Induced Obese Rats
by: Chorng-An Liao, et al.
Published: (2022-01-01)

Effects of Live and Pasteurized Forms of Akkermansia from the Human Gut on Obesity and Metabolic Dysregulation
by: Yura Choi, et al.
Published: (2021-09-01)

Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice
by: Xiaoxiang Gao, et al.
Published: (2024-01-01)

Gut microbiota remodeling improves natural aging-related disorders through Akkermansia muciniphila and its derived acetic acid
by: Junli Ma, et al.
Published: (2023-03-01)

Comparing the Effects of Live and Pasteurized Akkermansia muciniphila on Management of Obesity and Diabetes
by: Arefeh Shahriary, et al.
Published: (2021-01-01)

Nuclear hormone receptor NHR-49 is an essential regulator of stress resilience and healthy aging in Caenorhabditis elegans
by: Kelsie R. S. Doering, et al.
Published: (2023-08-01)

EGCG regulates fatty acid metabolism of high-fat diet-fed mice in association with enrichment of gut Akkermansia muciniphila
by: Xiaoxia Liu, et al.
Published: (2020-12-01)