Posttraumatic Osteomyelitis Risks Associated with <i>NLRP3</i> Gene Polymorphisms in the Chinese Population
The purpose of this case–control study was to examine possible links between <i>NLRP3</i> gene polymorphisms and the risk of developing posttraumatic osteomyelitis (PTOM) in the Chinese population. A total of 306 patients with PTOM and 368 normal controls were genotyped for <i>NLRP...
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MDPI AG
2023-01-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/2/253 |
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| author | Yudun Qu Jiaxuan Li Wei Zhang Changliang Xia Shuanji Ou Yang Yang Nan Jiang Yunfei Ma Yong Qi Changpeng Xu |
| author_facet | Yudun Qu Jiaxuan Li Wei Zhang Changliang Xia Shuanji Ou Yang Yang Nan Jiang Yunfei Ma Yong Qi Changpeng Xu |
| author_sort | Yudun Qu |
| collection | DOAJ |
| description | The purpose of this case–control study was to examine possible links between <i>NLRP3</i> gene polymorphisms and the risk of developing posttraumatic osteomyelitis (PTOM) in the Chinese population. A total of 306 patients with PTOM and 368 normal controls were genotyped for <i>NLRP3</i> (rs35829419, rs10754558, rs7525979, rs4612666), <i>ELP2</i> (rs1785929, rs1789547, rs1785928, rs12185396, rs681757, rs8299, rs2032206, rs559289), <i>STAT3</i> (rs4796793, rs744166, rs1026916, rs2293152, rs1053004), <i>CASP1</i> (rs501192, rs580253, rs556205, rs530537), NFKBIA (rs696), <i>NFKB1</i> (rs4648068), <i>CARD8</i> (rs204321), and <i>CD14</i> (rs2569190) using the genotyping technique SNaPshot. The genotype distributions of <i>NLRP3</i> gene rs10754558 (<i>p</i> = 0.047) and rs7525979 (<i>p</i> = 0.048) significantly differed between the patients and the healthy controls. Additionally, heterozygous models indicated a significant association between <i>NLRP3</i> rs10754558 and the likelihood of developing PTOM (OR = 1.600, <i>p</i> = 0.039), as did recessive and homozygous models of <i>NLRP3</i> rs7525979 (OR = 0.248, <i>p</i> = 0.019 and 0.239, <i>p</i> = 0.016, respectively). Collectively, our findings suggest that, in the Chinese population, the risk of developing PTOM was increased by the association between <i>NLRP3</i> rs10754558 and rs7525979. Therefore, our findings may provide novel insights and guidance in the prevention and development of PTOM. |
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| spelling | doaj.art-c083ae6658644e7daa6ce964ba02b6252023-11-16T21:32:51ZengMDPI AGJournal of Personalized Medicine2075-44262023-01-0113225310.3390/jpm13020253Posttraumatic Osteomyelitis Risks Associated with <i>NLRP3</i> Gene Polymorphisms in the Chinese PopulationYudun Qu0Jiaxuan Li1Wei Zhang2Changliang Xia3Shuanji Ou4Yang Yang5Nan Jiang6Yunfei Ma7Yong Qi8Changpeng Xu9Department of Orthopaedics, Guangdong Second Provincial General Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510317, ChinaDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510317, ChinaDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, NO.466 Xingang Road, Haizhu District, Guangzhou 510317, ChinaDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, NO.466 Xingang Road, Haizhu District, Guangzhou 510317, ChinaDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, NO.466 Xingang Road, Haizhu District, Guangzhou 510317, ChinaDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, NO.466 Xingang Road, Haizhu District, Guangzhou 510317, ChinaDepartment of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou 510445, ChinaDepartment of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou 510445, ChinaDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, NO.466 Xingang Road, Haizhu District, Guangzhou 510317, ChinaDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, NO.466 Xingang Road, Haizhu District, Guangzhou 510317, ChinaThe purpose of this case–control study was to examine possible links between <i>NLRP3</i> gene polymorphisms and the risk of developing posttraumatic osteomyelitis (PTOM) in the Chinese population. A total of 306 patients with PTOM and 368 normal controls were genotyped for <i>NLRP3</i> (rs35829419, rs10754558, rs7525979, rs4612666), <i>ELP2</i> (rs1785929, rs1789547, rs1785928, rs12185396, rs681757, rs8299, rs2032206, rs559289), <i>STAT3</i> (rs4796793, rs744166, rs1026916, rs2293152, rs1053004), <i>CASP1</i> (rs501192, rs580253, rs556205, rs530537), NFKBIA (rs696), <i>NFKB1</i> (rs4648068), <i>CARD8</i> (rs204321), and <i>CD14</i> (rs2569190) using the genotyping technique SNaPshot. The genotype distributions of <i>NLRP3</i> gene rs10754558 (<i>p</i> = 0.047) and rs7525979 (<i>p</i> = 0.048) significantly differed between the patients and the healthy controls. Additionally, heterozygous models indicated a significant association between <i>NLRP3</i> rs10754558 and the likelihood of developing PTOM (OR = 1.600, <i>p</i> = 0.039), as did recessive and homozygous models of <i>NLRP3</i> rs7525979 (OR = 0.248, <i>p</i> = 0.019 and 0.239, <i>p</i> = 0.016, respectively). Collectively, our findings suggest that, in the Chinese population, the risk of developing PTOM was increased by the association between <i>NLRP3</i> rs10754558 and rs7525979. Therefore, our findings may provide novel insights and guidance in the prevention and development of PTOM.https://www.mdpi.com/2075-4426/13/2/253single-nucleotide polymorphismsposttraumatic osteomyelitisrs10754558rs7525979case–control study |
| spellingShingle | Yudun Qu Jiaxuan Li Wei Zhang Changliang Xia Shuanji Ou Yang Yang Nan Jiang Yunfei Ma Yong Qi Changpeng Xu Posttraumatic Osteomyelitis Risks Associated with <i>NLRP3</i> Gene Polymorphisms in the Chinese Population Journal of Personalized Medicine single-nucleotide polymorphisms posttraumatic osteomyelitis rs10754558 rs7525979 case–control study |
| title | Posttraumatic Osteomyelitis Risks Associated with <i>NLRP3</i> Gene Polymorphisms in the Chinese Population |
| title_full | Posttraumatic Osteomyelitis Risks Associated with <i>NLRP3</i> Gene Polymorphisms in the Chinese Population |
| title_fullStr | Posttraumatic Osteomyelitis Risks Associated with <i>NLRP3</i> Gene Polymorphisms in the Chinese Population |
| title_full_unstemmed | Posttraumatic Osteomyelitis Risks Associated with <i>NLRP3</i> Gene Polymorphisms in the Chinese Population |
| title_short | Posttraumatic Osteomyelitis Risks Associated with <i>NLRP3</i> Gene Polymorphisms in the Chinese Population |
| title_sort | posttraumatic osteomyelitis risks associated with i nlrp3 i gene polymorphisms in the chinese population |
| topic | single-nucleotide polymorphisms posttraumatic osteomyelitis rs10754558 rs7525979 case–control study |
| url | https://www.mdpi.com/2075-4426/13/2/253 |
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