Analysis of the expression profile of miRNAs related to skin photoaging in the GEO database
Background: Skin aging has recently gained significant attention in both society and skin care research. Understanding the biological processes of photoaging caused by long-term skin exposure to ultraviolet radiation is critical for preventing and treating skin aging. Therefore, it is important to i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2023-06-01
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| Series: | Chinese Journal of Plastic and Reconstructive Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2096691123000316 |
| _version_ | 1797802264679677952 |
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| author | KaHo LUI Haibo Zhao Jiaqi Sun Zeren Shen Jinghong Xu |
| author_facet | KaHo LUI Haibo Zhao Jiaqi Sun Zeren Shen Jinghong Xu |
| author_sort | KaHo LUI |
| collection | DOAJ |
| description | Background: Skin aging has recently gained significant attention in both society and skin care research. Understanding the biological processes of photoaging caused by long-term skin exposure to ultraviolet radiation is critical for preventing and treating skin aging. Therefore, it is important to identify genes related to skin photoaging and shed light on their functions. Methods: We used data from the Gene Expression Omnibus (GEO) database and conducted bioinformatics analyses to screen and extract microRNAs (miRNAs) and their downstream target genes related to skin photoaging, and to determine possible biological mechanisms of skin photoaging. Results: A total of 34 differentially expressed miRNAs and their downstream target genes potentially related to the biological process of skin photoaging were identified. Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that these target genes were enriched in pathways related to human papillomavirus infection, extracellular matrix (ECM)-receptor signaling, estrogen receptor, skin development, epidermal development, epidermal cell differentiation, keratinocyte differentiation, structural components of the ECM, structural components of the skin epidermis, and others. Conclusion: Based on the GEO database-derived findings, we determined that target genes of two miRNAs, namely miR-4667-5P-KRT79 and miR-139-5P-FOS, play an important role in skin photoaging. These observations could provide theoretical support and guidance for further research on skin aging-related biological processes. |
| first_indexed | 2024-03-13T05:03:13Z |
| format | Article |
| id | doaj.art-c083c17d7d6a49ebb19c261500c03b48 |
| institution | Directory Open Access Journal |
| issn | 2096-6911 |
| language | English |
| last_indexed | 2024-03-13T05:03:13Z |
| publishDate | 2023-06-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Chinese Journal of Plastic and Reconstructive Surgery |
| spelling | doaj.art-c083c17d7d6a49ebb19c261500c03b482023-06-17T05:18:05ZengKeAi Communications Co. Ltd.Chinese Journal of Plastic and Reconstructive Surgery2096-69112023-06-01525359Analysis of the expression profile of miRNAs related to skin photoaging in the GEO databaseKaHo LUI0Haibo Zhao1Jiaqi Sun2Zeren Shen3Jinghong Xu4Department of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaCorresponding authors. Department of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China.; Department of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaCorresponding authors. Department of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China.; Department of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaBackground: Skin aging has recently gained significant attention in both society and skin care research. Understanding the biological processes of photoaging caused by long-term skin exposure to ultraviolet radiation is critical for preventing and treating skin aging. Therefore, it is important to identify genes related to skin photoaging and shed light on their functions. Methods: We used data from the Gene Expression Omnibus (GEO) database and conducted bioinformatics analyses to screen and extract microRNAs (miRNAs) and their downstream target genes related to skin photoaging, and to determine possible biological mechanisms of skin photoaging. Results: A total of 34 differentially expressed miRNAs and their downstream target genes potentially related to the biological process of skin photoaging were identified. Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that these target genes were enriched in pathways related to human papillomavirus infection, extracellular matrix (ECM)-receptor signaling, estrogen receptor, skin development, epidermal development, epidermal cell differentiation, keratinocyte differentiation, structural components of the ECM, structural components of the skin epidermis, and others. Conclusion: Based on the GEO database-derived findings, we determined that target genes of two miRNAs, namely miR-4667-5P-KRT79 and miR-139-5P-FOS, play an important role in skin photoaging. These observations could provide theoretical support and guidance for further research on skin aging-related biological processes.http://www.sciencedirect.com/science/article/pii/S2096691123000316Skin photoagingmiRNAsGEO database |
| spellingShingle | KaHo LUI Haibo Zhao Jiaqi Sun Zeren Shen Jinghong Xu Analysis of the expression profile of miRNAs related to skin photoaging in the GEO database Chinese Journal of Plastic and Reconstructive Surgery Skin photoaging miRNAs GEO database |
| title | Analysis of the expression profile of miRNAs related to skin photoaging in the GEO database |
| title_full | Analysis of the expression profile of miRNAs related to skin photoaging in the GEO database |
| title_fullStr | Analysis of the expression profile of miRNAs related to skin photoaging in the GEO database |
| title_full_unstemmed | Analysis of the expression profile of miRNAs related to skin photoaging in the GEO database |
| title_short | Analysis of the expression profile of miRNAs related to skin photoaging in the GEO database |
| title_sort | analysis of the expression profile of mirnas related to skin photoaging in the geo database |
| topic | Skin photoaging miRNAs GEO database |
| url | http://www.sciencedirect.com/science/article/pii/S2096691123000316 |
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