Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids
Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/19/5/6080 |
| _version_ | 1818434794640375808 |
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| author | John R. Chevillet Inyoul Lee Hilary A. Briggs Yuqing He Kai Wang |
| author_facet | John R. Chevillet Inyoul Lee Hilary A. Briggs Yuqing He Kai Wang |
| author_sort | John R. Chevillet |
| collection | DOAJ |
| description | Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number of important findings. Despite the initial optimistic views of their potential for clinical application, there are currently no circulating miRNA-based diagnostics in use. In this article, we review the status of circulating miRNAs, examine different analytical approaches, and address some of the challenges and opportunities. |
| first_indexed | 2024-12-14T16:42:39Z |
| format | Article |
| id | doaj.art-c083c30d5f224143b21715d27952048a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T16:42:39Z |
| publishDate | 2014-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c083c30d5f224143b21715d27952048a2022-12-21T22:54:17ZengMDPI AGMolecules1420-30492014-05-011956080610510.3390/molecules19056080molecules19056080Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body FluidsJohn R. Chevillet0Inyoul Lee1Hilary A. Briggs2Yuqing He3Kai Wang4Institute for Systems Biology, Seattle, WA 98109, USAInstitute for Systems Biology, Seattle, WA 98109, USALaboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY 10065, USAInstitute of Medical Systems Biology, Guangdong Medical College, Dongguan, Guangdong 523808, ChinaInstitute for Systems Biology, Seattle, WA 98109, USACell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number of important findings. Despite the initial optimistic views of their potential for clinical application, there are currently no circulating miRNA-based diagnostics in use. In this article, we review the status of circulating miRNAs, examine different analytical approaches, and address some of the challenges and opportunities.http://www.mdpi.com/1420-3049/19/5/6080diagnosticexosomesmicrovesiclesquantitative methods |
| spellingShingle | John R. Chevillet Inyoul Lee Hilary A. Briggs Yuqing He Kai Wang Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids Molecules diagnostic exosomes microvesicles quantitative methods |
| title | Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids |
| title_full | Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids |
| title_fullStr | Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids |
| title_full_unstemmed | Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids |
| title_short | Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids |
| title_sort | issues and prospects of microrna based biomarkers in blood and other body fluids |
| topic | diagnostic exosomes microvesicles quantitative methods |
| url | http://www.mdpi.com/1420-3049/19/5/6080 |
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