CRISPR-Cas9 engineering of the RAG2 locus via complete coding sequence replacement for therapeutic applications
Abstract RAG2-SCID is a primary immunodeficiency caused by mutations in Recombination-activating gene 2 (RAG2), a gene intimately involved in the process of lymphocyte maturation and function. ex-vivo manipulation of a patient’s own hematopoietic stem and progenitor cells (HSPCs) using CRISPR-Cas9/r...
| Κύριοι συγγραφείς: | , , , , , , , , , , |
|---|---|
| Μορφή: | Άρθρο |
| Γλώσσα: | English |
| Έκδοση: |
Nature Portfolio
2023-10-01
|
| Σειρά: | Nature Communications |
| Διαθέσιμο Online: | https://doi.org/10.1038/s41467-023-42036-5 |