Constitutive Activation of β-Catenin in Differentiated Osteoclasts Induces Bone Loss in Mice

Constitutive Activation of β-Catenin in Differentiated Osteoclasts Induces Bone Loss in Mice

Background/Aims: Activation of the Wnt/β-catenin signalling pathway has been widely investigated in bone biology and shown to promote bone formation. However, its specific effects on osteoclast differentiation have not been fully elucidated. Our study aimed to identify the role of β-catenin in osteo...

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Bibliographic Details
Main Authors: Xin Sui, Shijian Deng, Mengmeng Liu, Linlin Fan, Yunfei Wang, Huaxing Xu, Yao Sun, Anil Kishen, Qi Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Β-catenin
Wnt/β-catenin signalling pathway
Osteoclast
Osteoclastogenesis
Bone homeostasis
Online Access:https://www.karger.com/Article/FullText/492549

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