Squamous cell carcinoma of the tongue in von Recklinghausen's disease: A case report
von Recklinghausen's disease (vRD) is an autosomal dominant neurogenetic disorder characterized by symptoms of neurofibroma and café-au-lait plaques. Although some nonepithelial tumors, such as malignant peripheral nerve sheath tumors and optic nerve gliomas, are closely associated with vRD, ca...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Oral and Maxillofacial Surgery Cases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214541922000141 |
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| author | Yusoon Kim Kazuhiro Yagihara Jun Sumino Miki Katsurano Mari Shibata Koichi Kadoya Ayataka Ishikawa |
| author_facet | Yusoon Kim Kazuhiro Yagihara Jun Sumino Miki Katsurano Mari Shibata Koichi Kadoya Ayataka Ishikawa |
| author_sort | Yusoon Kim |
| collection | DOAJ |
| description | von Recklinghausen's disease (vRD) is an autosomal dominant neurogenetic disorder characterized by symptoms of neurofibroma and café-au-lait plaques. Although some nonepithelial tumors, such as malignant peripheral nerve sheath tumors and optic nerve gliomas, are closely associated with vRD, carcinomas are quite rare.This study reports a case of squamous cell carcinoma of the tongue in a patient with vRD. A 54-year-old woman was referred to our hospital because of a painful mass on her tongue. Initial clinical examinations revealed a 12 mm-sized mass with indurated margins on the right lateral border of the tongue, with no metastasis observed. The cytological diagnosis was class V, which strongly suggested squamous cell carcinoma (cT1N0M0); therefore, partial glossectomy was performed. Histopathological examination confirmed the diagnosis of squamous cell carcinoma. Three months after the surgery, secondary metastatic foci were observed in the right cervical lymph nodes, and subsequent right neck dissection was performed. Histopathological examination confirmed three lymph node metastases out of the total resected lymph nodes. The patient was strictly followed up for two years without any evidence of disease. |
| first_indexed | 2024-04-14T05:20:48Z |
| format | Article |
| id | doaj.art-c0899de4ca624242928b5446a5f03ce8 |
| institution | Directory Open Access Journal |
| issn | 2214-5419 |
| language | English |
| last_indexed | 2024-04-14T05:20:48Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral and Maxillofacial Surgery Cases |
| spelling | doaj.art-c0899de4ca624242928b5446a5f03ce82022-12-22T02:10:13ZengElsevierOral and Maxillofacial Surgery Cases2214-54192022-06-0182100255Squamous cell carcinoma of the tongue in von Recklinghausen's disease: A case reportYusoon Kim0Kazuhiro Yagihara1Jun Sumino2Miki Katsurano3Mari Shibata4Koichi Kadoya5Ayataka Ishikawa6Department of Oral Surgery, Saitama Cancer Center, 780 Komuro, Ina-machi, Kitaadachi-gun, Saitama, 362-0806, Japan; Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyou-ku, Tokyo, 113-8510, JapanDepartment of Oral Surgery, Saitama Cancer Center, 780 Komuro, Ina-machi, Kitaadachi-gun, Saitama, 362-0806, Japan; Corresponding author. Department of Oral Surgery, Saitama Cancer Center, 780 Komuro, Ina, Kitaadachi, Saitama, 362-0806, Japan.Department of Oral Surgery, Saitama Cancer Center, 780 Komuro, Ina-machi, Kitaadachi-gun, Saitama, 362-0806, JapanDepartment of Oral Surgery, Saitama Cancer Center, 780 Komuro, Ina-machi, Kitaadachi-gun, Saitama, 362-0806, JapanDepartment of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyou-ku, Tokyo, 113-8510, JapanDepartment of Oral Surgery, Saitama Cancer Center, 780 Komuro, Ina-machi, Kitaadachi-gun, Saitama, 362-0806, Japan; Department of Oral and Maxillofacial Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, 2-1-1, Thushima-Naka, Kita-ku, Okayama-shi, Okamaya, 700-8530, JapanDepartment of Pathology, Saitama Cancer Center, 780 Komuro, Ina-machi, Kitaadachi-gun, Saitama, 362-0806, Japanvon Recklinghausen's disease (vRD) is an autosomal dominant neurogenetic disorder characterized by symptoms of neurofibroma and café-au-lait plaques. Although some nonepithelial tumors, such as malignant peripheral nerve sheath tumors and optic nerve gliomas, are closely associated with vRD, carcinomas are quite rare.This study reports a case of squamous cell carcinoma of the tongue in a patient with vRD. A 54-year-old woman was referred to our hospital because of a painful mass on her tongue. Initial clinical examinations revealed a 12 mm-sized mass with indurated margins on the right lateral border of the tongue, with no metastasis observed. The cytological diagnosis was class V, which strongly suggested squamous cell carcinoma (cT1N0M0); therefore, partial glossectomy was performed. Histopathological examination confirmed the diagnosis of squamous cell carcinoma. Three months after the surgery, secondary metastatic foci were observed in the right cervical lymph nodes, and subsequent right neck dissection was performed. Histopathological examination confirmed three lymph node metastases out of the total resected lymph nodes. The patient was strictly followed up for two years without any evidence of disease.http://www.sciencedirect.com/science/article/pii/S2214541922000141Neurofibromatosis type1Squamous cell carcinomavon Recklinghausen's disease |
| spellingShingle | Yusoon Kim Kazuhiro Yagihara Jun Sumino Miki Katsurano Mari Shibata Koichi Kadoya Ayataka Ishikawa Squamous cell carcinoma of the tongue in von Recklinghausen's disease: A case report Oral and Maxillofacial Surgery Cases Neurofibromatosis type1 Squamous cell carcinoma von Recklinghausen's disease |
| title | Squamous cell carcinoma of the tongue in von Recklinghausen's disease: A case report |
| title_full | Squamous cell carcinoma of the tongue in von Recklinghausen's disease: A case report |
| title_fullStr | Squamous cell carcinoma of the tongue in von Recklinghausen's disease: A case report |
| title_full_unstemmed | Squamous cell carcinoma of the tongue in von Recklinghausen's disease: A case report |
| title_short | Squamous cell carcinoma of the tongue in von Recklinghausen's disease: A case report |
| title_sort | squamous cell carcinoma of the tongue in von recklinghausen s disease a case report |
| topic | Neurofibromatosis type1 Squamous cell carcinoma von Recklinghausen's disease |
| url | http://www.sciencedirect.com/science/article/pii/S2214541922000141 |
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