Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction

Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction

Abstract Background Up-regulation of ceramides in pulmonary hypertension (PH), contributing to perturbations in sphingolipid homeostasis and the transition of cells to a senescence state. We assessed the safety, feasibility, and efficiency of acid ceramidase gene transfer in a rodent PH model. Metho...

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Bibliographic Details
Main Authors: Michael G. Katz, Yoav Hadas, Adam Vincek, Lina Freage-Kahn, Nataly Shtraizent, Jeko M. Madjarov, Peter Pastuszko, Efrat Eliyahu
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Respiratory Research
Subjects:
Pulmonary arterial hypertension
Gene therapy
Sphingolipid metabolism
Adeno-associated virus
And acid ceramidase
Online Access:https://doi.org/10.1186/s12931-023-02487-2

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