Cotransfected human chondrocytes: over-expression of IGF-I and SOX9 enhances the synthesis of cartilage matrix components collagen-II and glycosaminoglycans

Cotransfected human chondrocytes: over-expression of IGF-I and SOX9 enhances the synthesis of cartilage matrix components collagen-II and glycosaminoglycans

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Damage to cartilage causes a loss of type II collagen (Col-II) and glycosaminoglycans (GAG). To restore the original cartilage architecture, cell factors that stimulate Col-II and GAG production are needed. Insulin-like growth factor I (IGF-I) and transcription factor SOX9are essential for the synth...

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Bibliographic Details
Main Authors: M. Simental-Mendía, J. Lara-Arias, E. Álvarez-Lozano, S. Said-Fernández, A. Soto-Domínguez, G. R. Padilla-Rivas, H. G. Martínez-Rodríguez
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2015-12-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Type II collagen
Glycosaminoglycans
IGF-I/SOX9 transgenes
Human chondrocytes
Articular cartilage
Cotransfection
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001201063&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001201063&lng=en&tlng=en

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