Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis
Abstract Background Propofol has been the gold standard for anesthesia induction and maintenance due to its rapid onset and favorable pharmacokinetic properties. However, the search for alternative agents with improved safety and efficacy has led to the emergence of ciprofol (HSK3486), a structural...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Anesthesia, Analgesia and Critical Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s44158-024-00160-8 |
| _version_ | 1827264265875095552 |
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| author | Muhammad Hudaib Hurais Malik Syeda Javeria Zakir Samra Rabbani Dhanushan Gnanendran Abdul Rehman Shah Syed Noor Fatima Suri Javeria Khan Arham Iqbal Nowal Hussain Muhammad Abdullah Satesh Kumar Mahima Khatri Giustino Varrassi |
| author_facet | Muhammad Hudaib Hurais Malik Syeda Javeria Zakir Samra Rabbani Dhanushan Gnanendran Abdul Rehman Shah Syed Noor Fatima Suri Javeria Khan Arham Iqbal Nowal Hussain Muhammad Abdullah Satesh Kumar Mahima Khatri Giustino Varrassi |
| author_sort | Muhammad Hudaib |
| collection | DOAJ |
| description | Abstract Background Propofol has been the gold standard for anesthesia induction and maintenance due to its rapid onset and favorable pharmacokinetic properties. However, the search for alternative agents with improved safety and efficacy has led to the emergence of ciprofol (HSK3486), a structural analog of propofol. This systematic review and meta-analysis aim to comprehensively assess the safety and efficacy of ciprofol compared to propofol for anesthesia induction and maintenance in adult patients undergoing surgical procedures. Methods This study included only double-arm RCTs in which participants were aged eighteen or older undergoing surgery. For the statistical analysis of the extracted data, we employed RevMan 5.4.1. Results Ciprofol demonstrated a promising trend of higher anesthesiologists’ satisfaction during the induction phase (MD 0.14, 95%, CI − 0.28 to 0.56, p = 0.51), whereas Propofol was favored during maintenance. Propofol also exhibited advantages with a shorter time to successful anesthesia induction (MD 0.08 min, 95% CI 0.00 to 0.15, p = 0.04), and quicker attainment of full alertness (MD 0.11 min, 95% CI − 1.29 to 1.52, p = 0.87), suggesting its efficiency in clinical practice. Importantly, there were no significant disparities in the success rate of anesthesia. Conclusion Both ciprofol and propofol demonstrate comparable efficacy and safety for anesthesia induction and maintenance in adult patients undergoing surgery. While propofol provides a faster onset of induction, ciprofol exhibits advantages in terms of pain management. Clinicians should consider these findings when selecting anesthetic agents, and tailoring choices to individual patient needs and clinical scenarios. |
| first_indexed | 2024-04-24T07:11:09Z |
| format | Article |
| id | doaj.art-c08bfd018fa6482a8fcbb38b77c98330 |
| institution | Directory Open Access Journal |
| issn | 2731-3786 |
| language | English |
| last_indexed | 2025-03-22T03:43:19Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Anesthesia, Analgesia and Critical Care |
| spelling | doaj.art-c08bfd018fa6482a8fcbb38b77c983302024-04-28T11:38:54ZengBMCJournal of Anesthesia, Analgesia and Critical Care2731-37862024-04-014111010.1186/s44158-024-00160-8Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysisMuhammad Hudaib0Hurais Malik1Syeda Javeria Zakir2Samra Rabbani3Dhanushan Gnanendran4Abdul Rehman Shah Syed5Noor Fatima Suri6Javeria Khan7Arham Iqbal8Nowal Hussain9Muhammad Abdullah10Satesh Kumar11Mahima Khatri12Giustino Varrassi13Fazaia Ruth Pfau Medical CollegeFazaia Ruth Pfau Medical CollegeDow University of Health SciencesDow University of Health SciencesYork and Scarborough Teaching Hospital, NHS Foundation TrustDow University of Health SciencesDow University of Health SciencesDow University of Health SciencesDow University of Health SciencesDow University of Health SciencesCMH Lahore Medical College and Institute of DentistryShaheed Mohtarma Benazir Bhutto Medical CollegeDow University of Health SciencesPaolo Procacci Foundation (PPF)Abstract Background Propofol has been the gold standard for anesthesia induction and maintenance due to its rapid onset and favorable pharmacokinetic properties. However, the search for alternative agents with improved safety and efficacy has led to the emergence of ciprofol (HSK3486), a structural analog of propofol. This systematic review and meta-analysis aim to comprehensively assess the safety and efficacy of ciprofol compared to propofol for anesthesia induction and maintenance in adult patients undergoing surgical procedures. Methods This study included only double-arm RCTs in which participants were aged eighteen or older undergoing surgery. For the statistical analysis of the extracted data, we employed RevMan 5.4.1. Results Ciprofol demonstrated a promising trend of higher anesthesiologists’ satisfaction during the induction phase (MD 0.14, 95%, CI − 0.28 to 0.56, p = 0.51), whereas Propofol was favored during maintenance. Propofol also exhibited advantages with a shorter time to successful anesthesia induction (MD 0.08 min, 95% CI 0.00 to 0.15, p = 0.04), and quicker attainment of full alertness (MD 0.11 min, 95% CI − 1.29 to 1.52, p = 0.87), suggesting its efficiency in clinical practice. Importantly, there were no significant disparities in the success rate of anesthesia. Conclusion Both ciprofol and propofol demonstrate comparable efficacy and safety for anesthesia induction and maintenance in adult patients undergoing surgery. While propofol provides a faster onset of induction, ciprofol exhibits advantages in terms of pain management. Clinicians should consider these findings when selecting anesthetic agents, and tailoring choices to individual patient needs and clinical scenarios.https://doi.org/10.1186/s44158-024-00160-8AnalgesiaAnesthesia inductionCiprofolGeneral anesthesiaPropofolDay surgery |
| spellingShingle | Muhammad Hudaib Hurais Malik Syeda Javeria Zakir Samra Rabbani Dhanushan Gnanendran Abdul Rehman Shah Syed Noor Fatima Suri Javeria Khan Arham Iqbal Nowal Hussain Muhammad Abdullah Satesh Kumar Mahima Khatri Giustino Varrassi Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis Journal of Anesthesia, Analgesia and Critical Care Analgesia Anesthesia induction Ciprofol General anesthesia Propofol Day surgery |
| title | Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis |
| title_full | Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis |
| title_short | Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis |
| title_sort | efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia a systematic review and meta analysis |
| topic | Analgesia Anesthesia induction Ciprofol General anesthesia Propofol Day surgery |
| url | https://doi.org/10.1186/s44158-024-00160-8 |
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