Serine Palmitoyltransferase Gene Silencing Prevents Ceramide Accumulation and Insulin Resistance in Muscles in Mice Fed a High-Fat Diet

Serine Palmitoyltransferase Gene Silencing Prevents Ceramide Accumulation and Insulin Resistance in Muscles in Mice Fed a High-Fat Diet

Skeletal muscles account for ~80% of insulin-stimulated glucose uptake and play a key role in lipid metabolism. Consumption of a high-fat diet (HFD) contributes to metabolic changes in muscles, including the development of insulin resistance. The studies carried out to date indicate that the accumul...

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Bibliographic Details
Main Authors: Monika Imierska, Piotr Zabielski, Kamila Roszczyc-Owsiejczuk, Emilia Sokołowska, Karolina Pogodzińska, Iwona Kojta, Agnieszka Błachnio-Zabielska
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
insulin resistance
ceramide
skeletal muscle lipid metabolism
gene silencing
electroporation
Online Access:https://www.mdpi.com/2073-4409/11/7/1123

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