Properties of a Telomerase-Specific Cre/Lox Switch for Transcriptionally Targeted Cancer Gene Therapy

Properties of a Telomerase-Specific Cre/Lox Switch for Transcriptionally Targeted Cancer Gene Therapy

Telomerase expression represents a good target for cancer gene therapy. The promoters of the core telomerase catalytic [human telomerase reverse transcriptase (hTERT)] and RNA [human telomerase RNA (hTR)] subunits show selective activity in cancer cells but not in normal cells. This property can be...

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Bibliographic Details
Main Authors: Alan E. Bilsland, Aileen Fletcher-Monaghan, W. Nicol Keith
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Telomerase
hTR
hTERT
Cre recombinase
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800375

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