Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?
Minimum information models are reporting frameworks that describe the essential information that needs to be provided in a publication, so that the work can be repeated or compared to other work. In 2016, Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) was created to standardi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2023-05-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/15352.pdf |
| _version_ | 1797413344955596800 |
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| author | Ayesha Sahar Ioana Nicorescu Gabrielle Barran Megan Paterson Catharien M.U. Hilkens Phillip Lord |
| author_facet | Ayesha Sahar Ioana Nicorescu Gabrielle Barran Megan Paterson Catharien M.U. Hilkens Phillip Lord |
| author_sort | Ayesha Sahar |
| collection | DOAJ |
| description | Minimum information models are reporting frameworks that describe the essential information that needs to be provided in a publication, so that the work can be repeated or compared to other work. In 2016, Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) was created to standardize the reporting on tolerogenic antigen-presenting cells, including tolerogenic dendritic cells (tolDCs). tolDCs is a generic term for dendritic cells that have the ability to (re-)establish immune tolerance; they have been developed as a cell therapy for autoimmune diseases or for the prevention of transplant rejection. Because protocols to generate these therapeutic cells vary widely, MITAP was deemed to be a pivotal reporting tool by and for the tolDC community. In this paper, we explored the impact that MITAP has had on the tolDC field. We did this by examining a subset of the available literature on tolDCs. Our analysis shows that MITAP is used in only the minority of relevant papers (14%), but where it is used the amount of metadata available is slightly increased over where it is not. From this, we conclude that MITAP has been a partial success, but that much more needs to be done if standardized reporting is to become common within the discipline. |
| first_indexed | 2024-03-09T05:16:19Z |
| format | Article |
| id | doaj.art-c08dd9c80569471c8352c46799f43edb |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T05:16:19Z |
| publishDate | 2023-05-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-c08dd9c80569471c8352c46799f43edb2023-12-03T12:44:58ZengPeerJ Inc.PeerJ2167-83592023-05-0111e1535210.7717/peerj.15352Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?Ayesha Sahar0Ioana Nicorescu1Gabrielle Barran2Megan Paterson3Catharien M.U. Hilkens4Phillip Lord5School of Computing Science, Newcastle University, Newcastle Upon Tyne, United KingdomTranslational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United KingdomTranslational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United KingdomTranslational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United KingdomTranslational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United KingdomSchool of Computing Science, Newcastle University, Newcastle Upon Tyne, United KingdomMinimum information models are reporting frameworks that describe the essential information that needs to be provided in a publication, so that the work can be repeated or compared to other work. In 2016, Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) was created to standardize the reporting on tolerogenic antigen-presenting cells, including tolerogenic dendritic cells (tolDCs). tolDCs is a generic term for dendritic cells that have the ability to (re-)establish immune tolerance; they have been developed as a cell therapy for autoimmune diseases or for the prevention of transplant rejection. Because protocols to generate these therapeutic cells vary widely, MITAP was deemed to be a pivotal reporting tool by and for the tolDC community. In this paper, we explored the impact that MITAP has had on the tolDC field. We did this by examining a subset of the available literature on tolDCs. Our analysis shows that MITAP is used in only the minority of relevant papers (14%), but where it is used the amount of metadata available is slightly increased over where it is not. From this, we conclude that MITAP has been a partial success, but that much more needs to be done if standardized reporting is to become common within the discipline.https://peerj.com/articles/15352.pdfTolerogenic dendritic cellCell therapyMinimum information modelReporting guidelinesStandardised data reportingOpen data sharing |
| spellingShingle | Ayesha Sahar Ioana Nicorescu Gabrielle Barran Megan Paterson Catharien M.U. Hilkens Phillip Lord Tolerogenic dendritic cell reporting: Has a minimum information model made a difference? PeerJ Tolerogenic dendritic cell Cell therapy Minimum information model Reporting guidelines Standardised data reporting Open data sharing |
| title | Tolerogenic dendritic cell reporting: Has a minimum information model made a difference? |
| title_full | Tolerogenic dendritic cell reporting: Has a minimum information model made a difference? |
| title_fullStr | Tolerogenic dendritic cell reporting: Has a minimum information model made a difference? |
| title_full_unstemmed | Tolerogenic dendritic cell reporting: Has a minimum information model made a difference? |
| title_short | Tolerogenic dendritic cell reporting: Has a minimum information model made a difference? |
| title_sort | tolerogenic dendritic cell reporting has a minimum information model made a difference |
| topic | Tolerogenic dendritic cell Cell therapy Minimum information model Reporting guidelines Standardised data reporting Open data sharing |
| url | https://peerj.com/articles/15352.pdf |
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