Pharmacological Preconditioning Using Diazoxide Regulates Store-Operated Ca2 + Channels in Adult Rat Cardiomyocytes

Pharmacological Preconditioning Using Diazoxide Regulates Store-Operated Ca2 + Channels in Adult Rat Cardiomyocytes

Voltage-dependent Ca2+ channels and store-operated Ca2+ channels (SOCs) are the major routes of Ca2+ entry into mammalian cells. Previously, we reported that pharmacological preconditioning (PPC) leads to a decrease in the amplitude of L-type calcium channel current in the heart. In this study, we e...

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Bibliographic Details
Main Authors: Raúl Sampieri, Eridani Fuentes, Elba D. Carrillo, Ascención Hernández, María C. García, Jorge A. Sánchez
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Physiology
Subjects:
Orai channels
STIM
SOCs
cardiomyocyte
pharmacological preconditioning
diazoxide
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01589/full

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