The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients
Background: The ongoing COVID-19 pandemic has put a constant strain on hospital resources, so there is a dire need for investigation methods that are widely available and that can predict mortality and the need for critical care. Hematological indices, which can be easily calculated from a complete...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/12/2037 |
| _version_ | 1797456813440892928 |
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| author | Andrei-Costin Chelariu Adorata Elena Coman Catalina Lionte Victoria Gorciac Victorita Sorodoc Raluca Ecaterina Haliga Ovidiu Rusalim Petris Cristina Bologa Gabriela Puha Alexandra Stoica Mihai Constantin Oana Sirbu Alexandr Ceasovschih Laurentiu Sorodoc |
| author_facet | Andrei-Costin Chelariu Adorata Elena Coman Catalina Lionte Victoria Gorciac Victorita Sorodoc Raluca Ecaterina Haliga Ovidiu Rusalim Petris Cristina Bologa Gabriela Puha Alexandra Stoica Mihai Constantin Oana Sirbu Alexandr Ceasovschih Laurentiu Sorodoc |
| author_sort | Andrei-Costin Chelariu |
| collection | DOAJ |
| description | Background: The ongoing COVID-19 pandemic has put a constant strain on hospital resources, so there is a dire need for investigation methods that are widely available and that can predict mortality and the need for critical care. Hematological indices, which can be easily calculated from a complete blood count (CBC), are useful in determining a patient’s inflammatory response to infectious diseases. Aim: This was a prospective cohort study that aimed to assess the prognostic value of scores based on CBCs in hospitalized patients with mild or moderate COVID-19 and medical comorbidities regarding the need for intensive care unit (ICU) therapy and short-term mortality. Methods: We included 607 patients with confirmed COVID-19, followed up for the need for ICU admission (15.5%) and 30 day mortality post-discharge (21.7%). CBC-derived scores were tested upon emergency department (ED) admission and after a median of 8 days. Results: In a multivariate model, elevated followed-up neutrophil-to-lymphocyte ratio (NLR) predicted increased odds for ICU admission (OR: 1.14 [95%CI: 1.06–1.22], <i>p</i> < 0.001) and short-term mortality (OR: 1.30 [95%CI: 1.09–1.57], <i>p</i> = 0.005). Monocyte-to-lymphocyte ratio (MLR) predicted 2.5-fold increased odds for ICU admission and 2.2-fold increased odds for mortality. Conclusion: NLR and MLR followed up 8 days post-admission are predictive for adverse outcomes in mild or moderate COVID-19 patients. |
| first_indexed | 2024-03-09T16:13:14Z |
| format | Article |
| id | doaj.art-c08ef1e67bbc497a8711cadbb70ce613 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T16:13:14Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-c08ef1e67bbc497a8711cadbb70ce6132023-11-24T16:02:34ZengMDPI AGJournal of Personalized Medicine2075-44262022-12-011212203710.3390/jpm12122037The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 PatientsAndrei-Costin Chelariu0Adorata Elena Coman1Catalina Lionte2Victoria Gorciac3Victorita Sorodoc4Raluca Ecaterina Haliga5Ovidiu Rusalim Petris6Cristina Bologa7Gabriela Puha8Alexandra Stoica9Mihai Constantin10Oana Sirbu11Alexandr Ceasovschih12Laurentiu Sorodoc13Hematology Department, Regional Institute of Oncology, 700483 Iasi, RomaniaSecond Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinical County Hospital, 700111 Iasi, RomaniaSecond Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinical County Hospital, 700111 Iasi, RomaniaInternal Medicine Department, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaSecond Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinical County Hospital, 700111 Iasi, RomaniaSecond Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinical County Hospital, 700111 Iasi, RomaniaInternal Medicine Department, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaSecond Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinical County Hospital, 700111 Iasi, RomaniaSecond Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinical County Hospital, 700111 Iasi, RomaniaSecond Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinical County Hospital, 700111 Iasi, RomaniaSecond Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinical County Hospital, 700111 Iasi, RomaniaSecond Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinical County Hospital, 700111 Iasi, RomaniaSecond Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinical County Hospital, 700111 Iasi, RomaniaSecond Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinical County Hospital, 700111 Iasi, RomaniaBackground: The ongoing COVID-19 pandemic has put a constant strain on hospital resources, so there is a dire need for investigation methods that are widely available and that can predict mortality and the need for critical care. Hematological indices, which can be easily calculated from a complete blood count (CBC), are useful in determining a patient’s inflammatory response to infectious diseases. Aim: This was a prospective cohort study that aimed to assess the prognostic value of scores based on CBCs in hospitalized patients with mild or moderate COVID-19 and medical comorbidities regarding the need for intensive care unit (ICU) therapy and short-term mortality. Methods: We included 607 patients with confirmed COVID-19, followed up for the need for ICU admission (15.5%) and 30 day mortality post-discharge (21.7%). CBC-derived scores were tested upon emergency department (ED) admission and after a median of 8 days. Results: In a multivariate model, elevated followed-up neutrophil-to-lymphocyte ratio (NLR) predicted increased odds for ICU admission (OR: 1.14 [95%CI: 1.06–1.22], <i>p</i> < 0.001) and short-term mortality (OR: 1.30 [95%CI: 1.09–1.57], <i>p</i> = 0.005). Monocyte-to-lymphocyte ratio (MLR) predicted 2.5-fold increased odds for ICU admission and 2.2-fold increased odds for mortality. Conclusion: NLR and MLR followed up 8 days post-admission are predictive for adverse outcomes in mild or moderate COVID-19 patients.https://www.mdpi.com/2075-4426/12/12/2037critical careshort-term mortalityneutrophil-to-lymphocyte ratiomonocyte-to-lymphocyte ratioCOVID-19outcome |
| spellingShingle | Andrei-Costin Chelariu Adorata Elena Coman Catalina Lionte Victoria Gorciac Victorita Sorodoc Raluca Ecaterina Haliga Ovidiu Rusalim Petris Cristina Bologa Gabriela Puha Alexandra Stoica Mihai Constantin Oana Sirbu Alexandr Ceasovschih Laurentiu Sorodoc The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients Journal of Personalized Medicine critical care short-term mortality neutrophil-to-lymphocyte ratio monocyte-to-lymphocyte ratio COVID-19 outcome |
| title | The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients |
| title_full | The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients |
| title_fullStr | The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients |
| title_full_unstemmed | The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients |
| title_short | The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients |
| title_sort | value of early and follow up elevated scores based on peripheral complete blood cell count for predicting adverse outcomes in covid 19 patients |
| topic | critical care short-term mortality neutrophil-to-lymphocyte ratio monocyte-to-lymphocyte ratio COVID-19 outcome |
| url | https://www.mdpi.com/2075-4426/12/12/2037 |
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