Relationship between cumulative exposure to triglyceride-glucose index and heart failure: a prospective cohort study
Abstract Background High triglyceride-glucose index (TyG) is a major risk factor for heart failure, but the long-term effect of high TyG index on the risk of developing heart failure remains unclear. Therefore, we aimed to determine the relationship between the cumulative exposure to TyG index and t...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-023-01967-5 |
| _version_ | 1797578344784461824 |
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| author | Huancong Zheng Guanzhi Chen Kuangyi Wu Weiqiang Wu Zegui Huang Xianxuan Wang Zekai Chen Zefeng Cai Zhiwei Cai Yulong Lan Shouling Wu Youren Chen |
| author_facet | Huancong Zheng Guanzhi Chen Kuangyi Wu Weiqiang Wu Zegui Huang Xianxuan Wang Zekai Chen Zefeng Cai Zhiwei Cai Yulong Lan Shouling Wu Youren Chen |
| author_sort | Huancong Zheng |
| collection | DOAJ |
| description | Abstract Background High triglyceride-glucose index (TyG) is a major risk factor for heart failure, but the long-term effect of high TyG index on the risk of developing heart failure remains unclear. Therefore, we aimed to determine the relationship between the cumulative exposure to TyG index and the risk of heart failure. Methods A total of 56,149 participants from the Kailuan Study, who participated in three consecutive health examinations in 2006, 2008, and 2010 and had no history of heart failure or cancer were recruited for this study. The cumulative TyG index was calculated as the weighted sum (value × time) of the mean TyG index for each time interval. The participants were placed into quartiles based on their cumulative TyG index. The study ended on December 31, 2020, and the primary outcome was new-onset heart failure during the follow-up period. In addition, a Cox proportional hazards regression model and a restricted cubic spline analysis were used to further evaluate the relationship between cumulative TyG index and the risk of heart failure. Results During a median follow-up period of 10.04 years, a total of 1,312 new heart failure events occurred. After adjustment for potential confounding factors, the Cox regression analysis showed that the hazard ratios (95% confidence intervals) for the risk of heart failure in the Q2, Q3, and Q4 groups were 1.02 (0.83,1.25), 1.29 (1.07,1.56) and 1.40 (1.15,1.71), respectively, vs. the Q1 group. The subgroup analysis showed a significant interaction between cumulative TyG index and BMI or waist circumference, but there was no interaction between age, sex and cumulative TyG index. The restricted cubic spline analysis showed a dose-response relationship between cumulative TyG index and the risk of heart failure. In addition, the sensitivity analysis generated results that were consistent with the primary results. Conclusions High cumulative TyG index is associated with a higher risk of heart failure. Thus, the TyG index may be useful for the identification of individuals at high risk of heart failure. The present findings emphasize the importance of the long-term monitoring of the TyG index in clinical practice. |
| first_indexed | 2024-03-10T22:21:37Z |
| format | Article |
| id | doaj.art-c090058f69d0458ebdb6d702ae481f6b |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-10T22:21:37Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-c090058f69d0458ebdb6d702ae481f6b2023-11-19T12:17:12ZengBMCCardiovascular Diabetology1475-28402023-09-0122111110.1186/s12933-023-01967-5Relationship between cumulative exposure to triglyceride-glucose index and heart failure: a prospective cohort studyHuancong Zheng0Guanzhi Chen1Kuangyi Wu2Weiqiang Wu3Zegui Huang4Xianxuan Wang5Zekai Chen6Zefeng Cai7Zhiwei Cai8Yulong Lan9Shouling Wu10Youren Chen11Department of Cardiology, Second Affiliated Hospital of Shantou University Medical CollegeCardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Second Affiliated Hospital of Shantou University Medical CollegeDepartment of Cardiology, Second Affiliated Hospital of Shantou University Medical CollegeDepartment of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityDepartment of Cardiology, Second Affiliated Hospital of Shantou University Medical CollegeDepartment of Epidemiology, University Medical Center Groningen, University of GroningenDepartment of Cardiology, Second Affiliated Hospital of Shantou University Medical CollegeDepartment of Cardiology, Second Affiliated Hospital of Shantou University Medical CollegeDepartment of Cardiology, Second Affiliated Hospital of Shantou University Medical CollegeDepartment of Cardiology, Kailuan General HospitalDepartment of Cardiology, Second Affiliated Hospital of Shantou University Medical CollegeAbstract Background High triglyceride-glucose index (TyG) is a major risk factor for heart failure, but the long-term effect of high TyG index on the risk of developing heart failure remains unclear. Therefore, we aimed to determine the relationship between the cumulative exposure to TyG index and the risk of heart failure. Methods A total of 56,149 participants from the Kailuan Study, who participated in three consecutive health examinations in 2006, 2008, and 2010 and had no history of heart failure or cancer were recruited for this study. The cumulative TyG index was calculated as the weighted sum (value × time) of the mean TyG index for each time interval. The participants were placed into quartiles based on their cumulative TyG index. The study ended on December 31, 2020, and the primary outcome was new-onset heart failure during the follow-up period. In addition, a Cox proportional hazards regression model and a restricted cubic spline analysis were used to further evaluate the relationship between cumulative TyG index and the risk of heart failure. Results During a median follow-up period of 10.04 years, a total of 1,312 new heart failure events occurred. After adjustment for potential confounding factors, the Cox regression analysis showed that the hazard ratios (95% confidence intervals) for the risk of heart failure in the Q2, Q3, and Q4 groups were 1.02 (0.83,1.25), 1.29 (1.07,1.56) and 1.40 (1.15,1.71), respectively, vs. the Q1 group. The subgroup analysis showed a significant interaction between cumulative TyG index and BMI or waist circumference, but there was no interaction between age, sex and cumulative TyG index. The restricted cubic spline analysis showed a dose-response relationship between cumulative TyG index and the risk of heart failure. In addition, the sensitivity analysis generated results that were consistent with the primary results. Conclusions High cumulative TyG index is associated with a higher risk of heart failure. Thus, the TyG index may be useful for the identification of individuals at high risk of heart failure. The present findings emphasize the importance of the long-term monitoring of the TyG index in clinical practice.https://doi.org/10.1186/s12933-023-01967-5Triglyceride-glucose indexCumulative exposureInsulin resistanceHeart failure |
| spellingShingle | Huancong Zheng Guanzhi Chen Kuangyi Wu Weiqiang Wu Zegui Huang Xianxuan Wang Zekai Chen Zefeng Cai Zhiwei Cai Yulong Lan Shouling Wu Youren Chen Relationship between cumulative exposure to triglyceride-glucose index and heart failure: a prospective cohort study Cardiovascular Diabetology Triglyceride-glucose index Cumulative exposure Insulin resistance Heart failure |
| title | Relationship between cumulative exposure to triglyceride-glucose index and heart failure: a prospective cohort study |
| title_full | Relationship between cumulative exposure to triglyceride-glucose index and heart failure: a prospective cohort study |
| title_fullStr | Relationship between cumulative exposure to triglyceride-glucose index and heart failure: a prospective cohort study |
| title_full_unstemmed | Relationship between cumulative exposure to triglyceride-glucose index and heart failure: a prospective cohort study |
| title_short | Relationship between cumulative exposure to triglyceride-glucose index and heart failure: a prospective cohort study |
| title_sort | relationship between cumulative exposure to triglyceride glucose index and heart failure a prospective cohort study |
| topic | Triglyceride-glucose index Cumulative exposure Insulin resistance Heart failure |
| url | https://doi.org/10.1186/s12933-023-01967-5 |
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