Fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the TGF-β1/Smad pathway: implications for liver cancer

Fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the TGF-β1/Smad pathway: implications for liver cancer

Objectives Liver fibrosis is a key stage in the progression of various chronic liver diseases to cirrhosis and liver cancer, but at present, there is no effective treatment. This study investigated the therapeutic effect of the new antifibrotic drug fluorofenidone (AKF-PD) on liver fibrosis and its...

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Bibliographic Details
Main Authors: Xiongqun Peng, Huixiang Yang, Lijian Tao, Jingni Xiao, Ya Zeng, Yueming Shen, Xueke Yu, Fei Zhu, Jiao Qin
Format: Article
Language:English
Published: PeerJ Inc. 2023-09-01
Series:PeerJ
Subjects:
AKF-PD
Liver fibrosis
Autophagy
Hepatic stellate cell
TGF-β1/Smad pathway
Online Access:https://peerj.com/articles/16060.pdf

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