Glomerulopathy Associated With Moderate Obesity
Obesity-related glomerulopathy is an established secondary glomerular disease that may occur in obese individuals with a body mass index (BMI) of ≥30 kg/m2. However, patients with moderate obesity (BMI ≤ 30 kg/m2) may also develop this disease. Methods: A total of 20 patients with grade 1 obesity (2...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-11-01
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| Series: | Kidney International Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468024916300584 |
| _version_ | 1811319060921581568 |
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| author | Yusuke Okabayashi Nobuo Tsuboi Takaya Sasaki Kotaro Haruhara Go Kanzaki Kentaro Koike Yoichi Miyazaki Tetsuya Kawamura Makoto Ogura Takashi Yokoo |
| author_facet | Yusuke Okabayashi Nobuo Tsuboi Takaya Sasaki Kotaro Haruhara Go Kanzaki Kentaro Koike Yoichi Miyazaki Tetsuya Kawamura Makoto Ogura Takashi Yokoo |
| author_sort | Yusuke Okabayashi |
| collection | DOAJ |
| description | Obesity-related glomerulopathy is an established secondary glomerular disease that may occur in obese individuals with a body mass index (BMI) of ≥30 kg/m2. However, patients with moderate obesity (BMI ≤ 30 kg/m2) may also develop this disease.
Methods: A total of 20 patients with grade 1 obesity (25 ≤ BMI < 30 kg/m2) with persistent proteinuria, without evidence of other renal diseases, were analyzed retrospectively. These patients were compared with 20 patients with grade 2 or higher obesity (BMI ≥ 30 kg/m2) with persistent proteinuria. Biopsies of 31 kidney transplant donors as healthy controls were used to compare histologic parameters.
Results: Similar to the grade 2 or higher obesity group, the grade 1 obesity group had a male predominance (85%) and showed a high incidence of hypertension (80%). Urinary protein excretion and renal outcome parameters were comparable between the groups. Patients with grade 1 obesity showed typical histologic features of obesity-related glomerulopathy: low glomerular density with glomerulomegaly. The glomerular density and mean glomerular volume in the grade 1 group, the grade 2 or higher group, and the kidney transplant donors with grade 1 obesity were 1.6 ± 0.8 versus 1.4 ± 0.6 versus 3.0 ± 1.1 (per mm2) and 6.1 ± 2.1 versus 6.4 ± 1.6 versus 2.9 ± 0.8 (×106 μm3), respectively.
Discussion: A glomerulopathy similar to obesity-related glomerulopathy can occur in moderately obese individuals. Renal factor(s), such as low glomerular density, may thus underlie susceptibility to this disease entity as well as BMI. |
| first_indexed | 2024-04-13T12:36:43Z |
| format | Article |
| id | doaj.art-c0929dc30d6a48ef81c88a9980c074c5 |
| institution | Directory Open Access Journal |
| issn | 2468-0249 |
| language | English |
| last_indexed | 2024-04-13T12:36:43Z |
| publishDate | 2016-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney International Reports |
| spelling | doaj.art-c0929dc30d6a48ef81c88a9980c074c52022-12-22T02:46:39ZengElsevierKidney International Reports2468-02492016-11-011425025510.1016/j.ekir.2016.08.006Glomerulopathy Associated With Moderate ObesityYusuke Okabayashi0Nobuo Tsuboi1Takaya Sasaki2Kotaro Haruhara3Go Kanzaki4Kentaro Koike5Yoichi Miyazaki6Tetsuya Kawamura7Makoto Ogura8Takashi Yokoo9Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanObesity-related glomerulopathy is an established secondary glomerular disease that may occur in obese individuals with a body mass index (BMI) of ≥30 kg/m2. However, patients with moderate obesity (BMI ≤ 30 kg/m2) may also develop this disease. Methods: A total of 20 patients with grade 1 obesity (25 ≤ BMI < 30 kg/m2) with persistent proteinuria, without evidence of other renal diseases, were analyzed retrospectively. These patients were compared with 20 patients with grade 2 or higher obesity (BMI ≥ 30 kg/m2) with persistent proteinuria. Biopsies of 31 kidney transplant donors as healthy controls were used to compare histologic parameters. Results: Similar to the grade 2 or higher obesity group, the grade 1 obesity group had a male predominance (85%) and showed a high incidence of hypertension (80%). Urinary protein excretion and renal outcome parameters were comparable between the groups. Patients with grade 1 obesity showed typical histologic features of obesity-related glomerulopathy: low glomerular density with glomerulomegaly. The glomerular density and mean glomerular volume in the grade 1 group, the grade 2 or higher group, and the kidney transplant donors with grade 1 obesity were 1.6 ± 0.8 versus 1.4 ± 0.6 versus 3.0 ± 1.1 (per mm2) and 6.1 ± 2.1 versus 6.4 ± 1.6 versus 2.9 ± 0.8 (×106 μm3), respectively. Discussion: A glomerulopathy similar to obesity-related glomerulopathy can occur in moderately obese individuals. Renal factor(s), such as low glomerular density, may thus underlie susceptibility to this disease entity as well as BMI.http://www.sciencedirect.com/science/article/pii/S2468024916300584body mass indexglomerular densityhyperfiltrationobesityrenal biopsy |
| spellingShingle | Yusuke Okabayashi Nobuo Tsuboi Takaya Sasaki Kotaro Haruhara Go Kanzaki Kentaro Koike Yoichi Miyazaki Tetsuya Kawamura Makoto Ogura Takashi Yokoo Glomerulopathy Associated With Moderate Obesity Kidney International Reports body mass index glomerular density hyperfiltration obesity renal biopsy |
| title | Glomerulopathy Associated With Moderate Obesity |
| title_full | Glomerulopathy Associated With Moderate Obesity |
| title_fullStr | Glomerulopathy Associated With Moderate Obesity |
| title_full_unstemmed | Glomerulopathy Associated With Moderate Obesity |
| title_short | Glomerulopathy Associated With Moderate Obesity |
| title_sort | glomerulopathy associated with moderate obesity |
| topic | body mass index glomerular density hyperfiltration obesity renal biopsy |
| url | http://www.sciencedirect.com/science/article/pii/S2468024916300584 |
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